Luke Roberts π©βπ¬
@Lukuscyte
Investigating mysteries of the immune system, particularly at the places where our body meets our environment | β₯ ILCs | he/him | π
Check out this cool @ImmunoSketch about recent work from @AntoniaCuff , @VikiLovesFACS (et al.) investigating ILC3s - the 'gardeners' of the human uterus !
Imagine the uterine lining as a garden, where special cells act as dedicated gardeners, keeping it healthy and vibrant. @VikiLovesFACS @AntoniaCuff @douglasagibson @imperialcollege biorxiv.org/content/10.110β¦
Can I catch a LIF(t)? ILC2 -derived LIF dictates migration of CCR7+ immune cells from the lung tissues to the lymph nodes, shaping transition from local tissue to systemic immunity.
Thrilled to see our recent work in @Nature . Here we describe how ILC2s regulates tissue localized vs systemic immunity. @MRC_LMB , @wellcometrust, @UKRI_News nature.com/articles/s4158β¦
Are you considering a PhD in Immunology/Parasitology?! Then the project below, supervised by @ProfJudiAllen and I, might be just what you're looking for! Interested candidates should reach out to discuss the selection process further. findaphd.com/phds/project/mβ¦
Exciting PhD opportunity in the Neves Lab with @GutOrganoid - apply by 29th October!
Looking for an exciting research project for a PhD? Would you like to work with mini-guts? Check out project 35 βDetermining the impact of pathogenic bacteria in the disruption of the intestinal barrierβ @The_MRCDTP to join our teams (#Neveslab, & #Garnettlab) Apply by 29 Oct
New lab colleagues just casually being brilliant! Congratulations @Alanna_Kelly__ !
Delighted to accept the Isil Berat Barlan Award for Young Scientists in Immunology at #ECI2024 @EFIS_Immunology . Great way to start the week ahead!
Free, and sure to be an amazing event!
Thrilled to see our recent work in @Nature . Here we describe how ILC2s regulates tissue localized vs systemic immunity. @MRC_LMB , @wellcometrust, @UKRI_News nature.com/articles/s4158β¦
Circadian-clock-controlled endocrine and cytokine signals regulate multipotential innate lymphoid cell progenitors in the bone marrow dlvr.it/T6bX05
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Thrilled to see our recent work in @Nature . Here we describe how ILC2s regulates tissue localized vs systemic immunity. @MRC_LMB , @wellcometrust, @UKRI_News nature.com/articles/s4158β¦
Thank you @organoidscience for sharing our most recent #organoids and #immune cells review with Emma Kromann and @ainize7 @CEIjournal.
π Researchers provided an overview of how intestinal #organoids are being co-cultured with #immune cells leading to substantial advances in our π understanding of immuneβepithelial interactions in the #gut. π Find out more at @CEIjournal | bit.ly/49I7ZIM
Dysregulated Wnt/Ξ²-catenin signaling impairs intestinal ILC3s through TCF-1/JunB/RORΞ³t regulation, disrupting intestinal homeostasis to promote inflammation and cancer @NatureComms nature.com/articles/s4146β¦
what an interesting Piezo work... activation of mechanosensitive Piezo1 channels supress ILC2 functions in humans and mice.
Hurrell, Akbari et al. @KECKSchool_USC show that, in murine & human ILC2s, Piezo1 channels are induced by allergen and cytokine encounter as activation decreases ILC2 effector functions and development of airway hyperreactivity in a KLF2-dependent manner. hubs.ly/Q02qLmYj0
2 x upcoming opportunities to join a fantastic group !
Hurrell, Akbari et al. @KECKSchool_USC show that, in murine & human ILC2s, Piezo1 channels are induced by allergen and cytokine encounter as activation decreases ILC2 effector functions and development of airway hyperreactivity in a KLF2-dependent manner. hubs.ly/Q02qLmYj0