Luca Fava

Thrilled to share our latest collaboration with @villunger & @CeMM_News in print! 🧬 We show how extra centrosomes can drive cell death 💀⚰️. Huge congrats to @dario_rizz, @VincenzaVigo, and the members of both teams! science.org/doi/10.1126/sc…

Supported by renewed NIH funding, we are recruiting a postdoc! We are a developmental cell biology group, & we ❤️ centrosomes and RNA localization. To learn more about our research and team, visit leritlab.org Apply here: faculty-emory.icims.com/jobs/149999/po…

🚨 Hot off the press!!! Wanted to share this to celebrate the momentous achievement from the @GiuntaLab and for the human centromere / genomics communities as a whole... more posts to come next week but for now, happy Fourth & happy reading ❤️🧬💻 science.org/doi/10.1126/sc…

Con l'emendamento Centemero al DL Fiscale un'importante misura per innescare investimenti in -PMI italiane quotate -PIR -Startup -Debito pubblico @GiulioCentemero @AlbertoBagnai @MarcoOsnato @SaverioCongedo @toniricciardi Ci auspichiamo sostenuto da tutte le forze politiche!

Delighted to share our latest work showing how cells that evade #senescence after CDK4/6 inhibition are primed to become aneuploid because of their increased size. Great work by super PhD student Aanchal Pareri biorxiv.org/content/10.110…

Congrats @VincenzaVigo we are proud of you!

Excited to share our new preprint on @biorxivpreprint! We show that USP28 mutations found in cancer block its interaction with 53BP1, disrupting p53 stabilization. Check out the full story... biorxiv.org/content/10.110…

Sharing our latest work @UZH_en tracking DNA damage inheritance by Live+QIBC nature.com/articles/s4158…. Huge congrats to @APanagopoulos_, M. Stout and all co-authors for this tour de force! Beautifully summarized by @S_J_Aitken and E. Reilly @NatureNV nature.com/articles/d4158….

Check out our review on "PLK4: Master Regulator of Centriole Duplication and Its Therapeutic Potential". Everything you need to know about centriole duplication, mitotic stopwatch and TRIM37-mediated cancer-specific vulnerabilities. @Midori_RuruOta onlinelibrary.wiley.com/doi/10.1002/cm…

From our curated list of cis variants affecting post-transcriptional & translational mRNA regulation, we focused on a C>T SNP in the 3'UTR of DDIT4. One letter, big impact. Huge thanks to all co-AU, particularly @aromanel, @alunno_laura & M. H. Hamadou. biorxiv.org/content/10.110…

I'm happy to share that I've joined IFOM as a Junior Group Leader, leading the Functional Genomics of Cancer Immunity Laboratory! 🔬 The lab investigates the links between DNA damage response (DDR) and cancer immunity. Exciting times are ahead—stay tuned!

In L.A. heading to Ventura Beach for the #GRC on #mitochondria. Excited to share our long-standing work on mitochondria in #PKD and our more recent discovery of the cross-talk between #cilia and #mitochondria @ERC_Research

Online Now: Small-molecule RNA therapeutics to target prostate cancer dlvr.it/TJgYlq

We are accepting submissions for our upcoming special issue - Cilia and Flagella: from Basic Biology to Disease. This issue will be coordinated by two Guest Editors: Pleasantine Mill @Mill_lab and Lotte Pedersen @LottePedersen12. journals.biologists.com/jcs/pages/cilia

A CDK4-selective inhibitor puts the brakes on cancer cells dlvr.it/TJcFF9

How are chromosome breaks repaired and how is their repair influenced and facilitated by nuclear and genome dynamics? Fantastic initiative and collaboration with @KarimMekhail, @chiolo_lab, and @LabLegube. @NatRevMCB Link to article: rdcu.be/edViW

A study by the group of Marta Biagioli, featured on the cover of Molecular Therapy, explores how SINEUP-CHD8 molecules can modulate CHD8 protein levels, a key factor in neurodevelopmental disorders. 📖 Read more: cell.com/molecular-ther… #Neuroscience #Autism #RNA

Michael Caplan and myself have put together a thorough review on #PKD. We worked for over a year with multiple calls, long discussions, writing and re-writing…intense and fun! Hope the outcome is appreciable, final version in prep pubmed.ncbi.nlm.nih.gov/39938884/

❗️Excited to share my PhD work in Genome Biology: PRODE recovers essential and context-essential genes through neighborhood-informed scores. What is PRODE, and how does it help?👇

I am very proud to be part of the amazing team of researchers, scientists and clinicians who are all co-authors of the important research publication just released in Nature Medicine. The paper documents changes in my brain tumour & blood before and after I received neoadjuvant…

HLS, an autosomal recessive #ciliopathy, is associated with a mutation in the centriole protein HYLS1. Curinha, Holland et al @JohnsHopkins show that HYLS1 mutant mice exhibit developmental abnormalities, with #centriole integrity & #cilia assembly defects hubs.la/Q038p3mr0