Mark Levin
@LevinChem
Professor @UChiChemistry @group_levin Single-Atom Skeletal Editing Husband to @Lucia_Petito Dad to 👶👶 🐶 Views my own
Today in @ScienceMagazine, we report a method to replace the C2 of pyridines with N, affording pyridazines. The change from electronically consonant (pyridine) to dissonant (pyridazine) opens retrosyntheses not typically available to the latter. science.org/doi/10.1126/sc…
Less than a decade ago, reactions for adding, deleting, and swapping single atoms in complex organic molecules were almost unheard of. Now there’s a growing community of researchers working on them. cen.acs.org/synthesis/Skel…
Mechanisms & Synthetic Applications of Cyclic, Nonstabilized Isodiazenes: N-Atom Insertion into Pyrrolidines and Related Rearrangements | Journal of the American Chemical Society @LevinChem @group_levin @UChiChemistry @UChicago @uclachem @TAMUChemistry pubs.acs.org/doi/10.1021/ja…
# Paper of the Week This week we discussed the total synthesis of Perhydrobenzeindene of Prof.David Sarlah @SarlahLab and some brilliant literatures from the group of Prof. Zhang, Prof. Tao Tu , Prof. Mark D. Levin @LevinChem @group_levin
🚨Just out in Nature! We have offered a general method for 1,2-difunctionalization of arenes via differential 1,2-diborylation! rdcu.be/esXq8 nature.com/articles/s4158… Congratulations to Jingfeng!
Online today @NatureChemistry : nature.com/articles/s4155… Superstar Myojeong Kim has since started her lab at Yonsei - stay tuned for her next breakthrough!
How do you turn a deletion into an insertion? In our latest, Myojeong shows that the anomeric amide can N-delete *and* re-aminate a sulfinate intermediate, enabling an overall SO2 insertion. Another great collab with @ckellzchem and J&J! doi.org/10.26434/chemr…
Super thrilled to finally see this collaborative work between @JNJNews 's DPR, CCAP, and ISD groups with @LevinChem and @group_levin live on @NatureChemistry ! Here's to more fruitful endeavors in the world of molecular editing and deaminative functionalization! Link:…
Today, NSF announced an add’l 500 NSF Graduate Research Fellowship Program awardees for the 2025-2026 cohort, bringing the total to approx 1,500. #NSFGRFP supports grad students as they pursue their dreams, build STEM skills, & become the next generation of innovators & leaders.
🚨 A single-atom swap could change the game in drug discovery! 🧪💥 We have just unveiled a CO-to-S atom swap method that turns ketones into sulfur-containing frameworks in complex, bioactive molecules in just two steps. science.org/doi/10.1126/sc… Congratulations to Zining.
I really like the interpretability criterion. Kind of like the reactions used in degradation studies in the pre-NMR era. Human ability to interpret data is also a little bit counter to the prevalent black box approaches (feed the data, find the patterns).
A brief editorial with @SarpongGroup and @AlisonWendlandt where we try to answer an important question: What is Editing? pubs.acs.org/doi/full/10.10…
Proud to contribute to the @JacobsenLab Tetrahedron Prize Festschrift with this mechanistic study that shows some N-insertion reactions proposed to go through aziridines must be ring-opening instead. sciencedirect.com/science/articl…
"You put C3 in, you take C3 out, you put another one in and shake it all about..."
Carbon-Atom Scavengers Enable Divergent, Selective Carbon Deletion of Azaarenes | Journal of the American Chemical Society @UChicago @group_levin @LevinChem @UChiChemistry pubs.acs.org/doi/10.1021/ja…
Check out our latest work with @LevinChem, @ChemieJisoo, and @tergitezeqiri! #MerckChemistry
Our latest is a serendipitously discovered pair of reactions that can pull either the C2 or C3 carbon out of quinolines by choice of an amine scavenger. A deep mechanistic dive took us some surprising places, in @ChemieJisoo's latest. pubs.acs.org/doi/full/10.10… @alecchristian14