Rudolf Lab
@LabRudolf
Natural Products, Biosynthesis, Enzymology, Genome Mining, Bioengineering
The #BJOC thematic issue on Young investigators in natural products chemistry, biosynthesis, and enzymology is now complete! 31 contributions from young investigators around the world! Check it out! @BeilsteinInst beilstein-journals.org/bjoc/series/129
More exciting biosynthetic work on bacterial #eunicellane #diterpenoids out of the @Helfrich_lab!
Our study in ACS Chem Biol reveals a unique eunicellane pathway featuring a reductase fused with a terpene cyclase, a P450 split into 3 fragments and a hypothetical protein with dual isomerase and oxygenase functions! pubs.acs.org/doi/full/10.10…
Interested in a #PhD in #Chemistry? Or already plan to apply to @UFChemistry and want some more info? RSVP now for our virtual open house: Sat. Nov. 2 at 12 pm EDT. See you there! @UF
Checkout the JIMB issue on Natural Products academic.oup.com/jimb/pages/spe… Thank you authors! @marnixmedema @GillesvanWezel Michael Smanski, @BK_KAIST @hanzyduzit @lab_shen Dong-Chan Oh, @EustaquioLab @gerryiidr Hsiao-Ching Lin, Yousong Ding, @LabRudolf @ParkinsonLab and Ikuro Abe!
New brominated allianthrones with activity against triple negative breast cancer cells and fungal genome analysis! Great work by Paige Mandelare-Ruiz and in collaboration with April Risinger lab and @LabRudolf @Whitney_Lab @UFChemistry …mistry-europe.onlinelibrary.wiley.com/doi/abs/10.100…
Out now in @Chem_CP , we collaborate with @piel_lab to discover a prenyltransferase+terpene cyclase fusion enzyme that modifies Trp residues in RiPPs to yield complex steroid-like scaffolds! Congrats to @HubrichFlorian, @sanathrajkk0 for leading this!🎉authors.elsevier.com/c/1jjdi8jWHELG…
Bacteria are talented producers of #diterpenes. We screened 334 terpene synthases: doi.org/10.26434/chemr…. New skeletons, new stereoisomers, terpenes known in other organisms but new to bacteria. A massive team effort led by Xiuting Wei and Wenbo Ning! @UFChemistry
Our former postdoc Prof. Baofu Xu and his group just published in @NatureComms on the microeunicellol-type bacterial eunicellane #diterpenoids. Check it out here: rdcu.be/dOdoS #proudPI Congrats @Baofu_Xu!
A bit late, but wanted to share our newest paper in #BJOC on eunicellane #diterpene chemistry. @lizining666 Another fun collaboration with @TantilloLab @LoesgenLab! beilstein-journals.org/bjoc/articles/…
Daniel @dicenhour91 and Diana Łomowska-Keehner representing @rudolflab at @AmerChemSociety #FAME2024! Congrats to both you of for 2 great presentations!
We are excited to finally publish the unprecedented biosynthetic origins of enediyne natural products: iodinated polyynes! This transformative discovery is a huge milestone for these clinical antitumor antibiotics. @Kalkreuter @guichun98 @nchembio nature.com/articles/s4158…
Early Announcement! simbhq.org/np/ Together with Brad @BradMoore_SIO, Jaclyn @JMWinterlab, and Alessandra @EustaquioLab, We look forward to welcoming you to the 2025 @SIMB_Microbio Natural Product meeting at San Diego! Keynote speaker Prof. Jennifer Doudna! @doudna_lab
We are hiring an NIH-funded postdoc! Looking for a highly motivated researcher with a strong background in natural product isolation and structural characterization for #terpene NP discovery, #biosynthesis, #enzymology. Please RT! @UFChemistry explore.jobs.ufl.edu/en-us/job/5315…
Researchers @Fudan University 🇨🇳 focus on #chemoenzymatic synthesis of macrocyclic peptides and polyketides via #thioesterase-catalyzed #macrocyclization. #biosynthesis ➡️ beilstein-journals.org/bjoc/articles/… Thanks for guest editing @LabRudolf, @barra_lena and Takayoshi Awakawa! 💎🔓 #BJOC
Ever wonder what you might want to know about going to your first conference? How to navigate interacting at a scientific meeting? Check this out!! @pharmacognosy @youinthelab @ABRCMS
Our study in ACS Chem Biol reveals a unique eunicellane pathway featuring a reductase fused with a terpene cyclase, a P450 split into 3 fragments and a hypothetical protein with dual isomerase and oxygenase functions! pubs.acs.org/doi/full/10.10…