Chekan Lab
@ChekanLab
Assistant Professor UNC Greensboro | Natural Products | Biosynthesis | Genome Mining | Enzymology
Out now in @Chem_CP , we collaborate with @piel_lab to discover a prenyltransferase+terpene cyclase fusion enzyme that modifies Trp residues in RiPPs to yield complex steroid-like scaffolds! Congrats to @HubrichFlorian, @sanathrajkk0 for leading this!🎉authors.elsevier.com/c/1jjdi8jWHELG…
The #BJOC thematic issue on Young investigators in natural products chemistry, biosynthesis, and enzymology is now complete! 31 contributions from young investigators around the world! Check it out! @BeilsteinInst beilstein-journals.org/bjoc/series/129
Thrilled to share our work on the new plant Cu enzymes, BpCs! We offer mechanistic insights and structural recommendations for advancing BpC research. Thanks to @jess_panch for inviting us to publish in @TrendsChemistry ! 🌿🧬🧪 authors.elsevier.com/a/1jzvn9CpcYaQ…
When the standard approaches didn't work, @Chad46971777 came up with a new one to solve a synthetic challenge that @YeWangum was having. Mix in @AzamHussai70792 and the following @J_A_C_S paper was the result. @NarayanLab @MichiganChem @UMLifeSciences #biocatalysis
Ancestral Sequence Reconstruction to Enable Biocatalytic Synthesis of Azaphilones | Journal of the American Chemical Society @AlisonNarayanUM @UMichResearch @UMich @NarayanLab #Ancestral #Sequence #Reconstruction #Biocatalysis #Azaphilones pubs.acs.org/doi/10.1021/ja…
We studied rSAM, HtkB catalyze a His-to-Lys crosslink, and revealed conserved active site residues that influence substrate specificity. Brandon Morinaka Lab | RSC Chem Biol doi.org/10.1039/D4CB00…
Come join our awesome team @uncg_chem @UNCG. We are seeking a new colleague to teach organic chemistry to our absolutely amazing students! Please rt 🙏🧪⚗️🌞
Calling all Inorganic Chemists. Join our amazing department with a tenure track Assistant Professor position. I love @uncg_chem. Great colleagues, remarkable students, low cost of living. Check us out! spartantalent.uncg.edu/postings/30223
My amazing department, @bio_uncg, is hiring an Assistant Professor in Genetics/Cell Biology! Since starting @UNCG, I've felt incredibly supported and can't speak highly enough of this department! Please retweet and share with colleagues! spartantalent.uncg.edu/postings/30224
Delighted that a collaboration with @Nairlab_UIUC is now online @nchembio Nucleobases are common in biology but not in peptides. In this work, a nucleobase-peptide hybrid is generated from a ribosomal precursor peptide via YcaO domain protein catalysis. nature.com/articles/s4158…
Never underestimate a diiron enzyme. Congrats @sanjoyadak90 for bringing the nitrile synthase AetD to life with @Drennan_lab, Maria-Eirini Pandelia, and Ken Houk labs. Published today @NatureChemistry nature.com/articles/s4155…
Congrats to @HubrichFlorian & @sanathrajkk0 for this exciting story finally being published. Thanks for the fruitful collaboration with @chekanlab. If you are interested in the chemical space of #RiPP #biosynthetic #enyzmes and #isoprenoids, click here: sciencedirect.com/science/articl…
It was great working with you on this exciting project!
Very excited to share that one of the major projects from my postdoc in the wonderful @piel_lab is out now @Chem_CP. An amazing collaboration with the @ChekanLab and @sanathrajkk0 where we characterized RiPPs with polycyclic isoprene moieties🎉 authors.elsevier.com/c/1jjdi8jWHELG…
So excited that @uncg_chem has been awarded the 2024 @UNCG_CAS Diversity Award. Join us in person or virtually, September 10th at 3:30 EDT, to share ideas about inclusiveness in science. DM me for a link cas.uncg.edu/event/deans-di…
Thrilled to have accomplished a major career goal nearly 15 years in the making today! I showed my biochem class the 1971 stanford protein synthesis video. youtube.com/watch?v=u9dhO0…
Out now in @ACSCatalysis, we develop a chimeric fusion N-glycosyltransferase for targeted and selective peptide modification, especially in vivo. We use it to make a new glycocin derivative (RiPP NP). Congrats to @smith_ayoola for leading this work!🎉 pubs.acs.org/doi/10.1021/ac…
🔓Take a look in our latest issue at this #OpenAccess article by Jonathan Chekan, Roland Kersten & co @ChekanLab @kersten_lab highlighting the chemistry, biosynthesis & function of plant RiPPs 📍@uncg_chem @UMichPharmacy pubs.rsc.org/en/content/art…
Excited to share our latest work on a new subfamily of VHPOs that modify external AQ molecules and rescue bacterial growth! @JacksonBaumga10 drove this interdisciplinary effort with amazing MS imaging support from @nerdcitycat and @DrLauraSanchez! biorxiv.org/content/10.110…
Out now: We reassemble 700 public plant transcriptomes to mine potential for side chain crosslinked peptides in plants (burpitides). We found multiple phylogenetic hot spots supported by metabolomics. Congrats to Draco, @mikepasquale77, and Brigitte! beilstein-journals.org/bjoc/articles/…
