KleinerLab
@KleinerLabRNA
The Kleiner lab investigates the chemical biology of RNA modifications and their role in gene expression regulation. http://kleiner.princeton.edu
What drives cytoplasmic mRNA organization? We created unbiased, genome-wide maps of mesoscale RNA-RNA spatial proximity to find out - Biggest surprise was impact of encoded protein function. Fantastic work w/ @LindsayABecker @sofiquinodoz @david_a_knowles biorxiv.org/content/10.110…
The final version of our protein transposition manuscript is now published in @ScienceMagazine science.org/doi/10.1126/sc… We’ve added a few new things since our preprint /1
Ever wanted to swap out an entire internal region of a folded protein for functional biochemical studies? Check out our preprint that has been 5 years in the making, in which we establish a protein editing platform via protein transposition, enabling the insertion of functional…
In lab's #FIRSTPREPRINT, we present methods to measure nanometer organization around & between specific proteins in condensates. We uncover unexpected heterogeneity for a liquid-like phase with local meshwork spanning 10-50nm, stemming from ribosome biogenesis in the nucleolus.
Nanometer condensate organization in live cells derived from partitioning measurements biorxiv.org/content/10.110… #biorxiv_biophys
We are looking for a postdoc candidate in RNA chemical biology, broadly defined. Interested applicants can email me at [email protected] with their CV, research summary, and names of 3 references. kleiner.princeton.edu
Faculty & students from @EmmanuelCollege, @CSUSBNews and @_hamptonu spent the summer with @PrincetonChem as part of the Visiting Faculty Research Partnership, working on projects that form the core of their research at home but with special focus at Frick: bit.ly/4edp5B8
The LSI at Princeton University invites applications for a tenure-track faculty position at the Assistant Professor level. We are seeking outstanding scientists in experimental genomics, systems biology, biophysics, or quantitative biology. Apply: princeton.edu/acad-positions…
Congratulations to Qais Jaber, awarded a two-year @EMBO Postdoctoral Fellowship supporting excellent postdoc research. Qais will continue his work in the @KleinerLabRNA deciphering RNA modifications in pathogenic bacteria.
An honor to announce our book has been published! Many thanks to Martin Pettersson, the team at Wiley, and all our amazing contributors for making this exciting project happen! onlinelibrary.wiley.com/doi/book/10.10…
We are just opening the summer Visiting Faculty Research Partnership season and are thrilled to be hosting, among others, the Graham Chakafana Lab of @_HamptonU. The lab will be doing malaria research hosted by the @KleinerLabRNA. This marks their 2nd summer @PrincetonChem!
Ever wanted to incorporate ncAAs into your protein but found the efficiency to be too low? Check out our new preprint, where we turned a simple observation in protein translation to an effective quadruplet codon translation strategy!
Efficient Genetic Code Expansion Without Host Genome Modifications ift.tt/YImKuBd #biorxiv_synbio
"Here, we describe our efforts to illuminate RNA biology through the application of chemical tools, focusing on post-transcriptional regulatory mechanisms." Enabling technologies from @KleinerLabRNA pubs.acs.org/doi/10.1021/ac… #tbt #ACSChemicalBiology #methods @PrincetonChem
What a great Take Your Child to Work Day here @PrincetonChem with faculty, visitors, and kids enjoying crafts, lunch, and a campus-wide chem demo (thank you, @PrincetonPhys). Well done Sarah and Angie! #TYCTWD24
How to pick a problem. Today in @CellCellPress. 1/53 cell.com/cell/fulltext/…
New issue! 📣 Read up on detection of RNA-protein interactions, selenoneine biosynthesis, riboswitches, sirtuins, functional amyloids, and more! pubs.acs.org/toc/bichaw/62/… #amyloid #RNA #biosynthesis
Please see the amazing work done by @_xun_sun_ , published in Nat. Chem. today! Huge thanks to all of our great collaborators, Prof. Dr. Henning Mootz, Prof. Jhih-Wei Chu, Prof. Nozomi Ando (@AndoLab), and Prof. Tamiki Komatsuzaki (@HokkaidoUnivPR)! nature.com/articles/s4155…
Would you be surprised to learn that acid chlorides are not only compatible with biological research, in water mind you, but are in fact, AMAZING? Read on to see the answer… 1/n