Kerstin Thol

Glad I picked up my phone on a Friday afternoon one week before submitting my PhD thesis when Oriol called to ask for some urgent help with this. Even happier I was actually able to contribute a tiny bit to this gigantic effort. 🎉

🔥New #review out! We explore how experimental models and high-throughput sequencing (or, all the ✨#omics✨) complement each other in #metastasis research. Bridging these approaches can unlock deeper insights into #cancer progression and #treatment

🚀 Our paper introducing ImmuneLENS, a new tool that measures T and B cell fractions from WGS data. This builds on our previous method, T cell ExTRECT, that used a signal from V(D)J recombination to measure T cells. Out today in @NatureGenet doi.org/10.1038/s41588… 🧵👇

Our paper describing the use of an ultrasensitive circulating tumour DNA detection assay to stratify #TRACERx patients with early-stage non-small cell lung cancer pre-operatively for clinical outcome is out today @NatureMedicine. Thread below 👇

We managed to get one last paper rdcu.be/d5gAe over the line before the new year🥂! We are pleased to share the first Nature Cell Biology paper from our lab functionally validating the role of a frequently occurring lung cancer driver, FAT1 in cancer evolution. 🧵1/13

It’s been a long time coming…#PhDone

Check out our new paper on ecDNA! Tweetorial below. It’s been great working on this project with @cbailey_58, @oriol_pich et al. 🧬🍩

Keen to do a computational PhD? Are you of black heritage? @CharlesSwanton and I have a very exciting project exploring somatic evolution and beyond! Join the @CRUKCOLcentre Black Leaders in Cancer programme. Please RT! 🖥️🦀🧪🥼

Very exciting opportunity to work on harnessing computational approaches to develop T cell immunotherapies for childhood cancers. please RT! @straathof_karin @CancerGrand #nexTGen #childhoodcancer #Immunotherapy #cancerevolution

t-minus one month!! pls donate if you can / share the link:) thank you!! (big love to those who have already!💜) did a practice run the other day (first ever hm!) and I was in pain for two days after but hey, we live! (thank you @Apple for giving me a wee virtual gold medal)

Last day to apply to join @CharlesSwanton and @SwantonLab as a postdoc! Wet lab position, amazing colleagues and a chance to work at the world leading @TheCrick Apply here 👇 tinyurl.com/ye263rdv

📢📢 We're hiring! Just finished your PhD? Come help us figure out how cancers evolve and develop diagnostics. You'll work in a multi-lab team @EarlyCancerCam/@TheCrick and lead a stunning project on lung cancer. Flexible start date to Oct. Pls RT! jobs.cam.ac.uk/job/45357/

Had a great time at #GYSS2024 . Asked questions, got ideas, met great people, ate good food, talked so much I lost my voice. Off to go surfing now.

My sister setting the bar high (as per usual) for best paper title

CONIPHER, our method for automated reconstruction of tumour subclonal structure and phylogeny that we used in our recently published TRACERx studies, is now out in Nature Protocols! (nature.com/articles/s4159…). Welcome to the CONIPHER TREEtorial, just in time for Christmas! 🌲 1/n

📢The RNA single base substitution signatures we described in #TRACERx are online at COSMIC v3.4! Check them out if you're studying RNA editing in cancer Led by @CarlosEcolEvol with @NickyMcGranahan @CharlesSwanton Link: cancer.sanger.ac.uk/signatures/rna… Paper: nature.com/articles/s4158…

📢 PhD opportunity in my lab @EarlyCancerCam @CRUKCamCentre to unravel the story of how somatic evolution drives cancer working with great collaborators at @ucl & @TheCrick. Drive, curiosity and kind-heartedness are essential. We teach the rest tinyurl.com/5n7rb5rr

Thanks to everyone who attended our Early Career Researcher Cancer Showcase! Special thanks to @KerstinThol, Golestan Karami, Sunandini Ramnarayanan, Robert Scott & Ben Shum 🙌🏼 Missed it? The recording will be available soon here: ow.ly/bbUs50N5GhP @GeCIPteam #research

Very exciting being able to present our work on cancer genes and mutational signatures in lung tumours among a fantastic line up of speakers at #EACR2023 today!

We're thrilled to share work on tumour evolution in 421 TRACERx lung cancer patients by @AFrankell @Michi_Dii @drmaiseb @LimEmilia @TakKarasaki @Ward__Sophie RajuVeeriah @ColliverEmma @AMIHuebner @abi_bunkum @ZaccaSimo @MariamJHanjani @NickyMcGranahan🧵⬇️ nature.com/articles/s4158…