Daniel Strebinger

Retrotransposons are cool - but harnessing them for kilobase insertions AND seeing their molecular structure is even more exciting. Great work led by @GraceKC Check it out!!

Can we use RNA to insert kilobases of DNA into the human genome, opening up a new way to engineer cells or treat disease? Excited to share our latest work turning a retrotransposon (a “jumping gene” with an RNA intermediate) from songbirds into a genome editing tool. 🧵 (1/7)

We're hiring! Our lab at the Ragon Institute of MGB, MIT, and Harvard is looking for a motivated postdoc with experience in developing and applying deep learning models. You'll work at the intersection of spatial transcriptomics and structural biology. #postdoc

covercovercovercovercovercovercovercovercovercovercover this is terrifically exciting (Also please dw, the central dogma is still very much intact, this is just a bit of a funky spin on it)

Exciting work from @KalliKappel - using pooled optical screening to determine sequence features that contribute to condensate formation! If interested in this topic reach out to Kalli, who just started her lab at UCLA. She is an amazingly insightful scientist and a great person!

Introducing CondenSeq, an imaging-based high-throughput approach for characterizing protein condensates within the nuclear environment. @KalliKappel nature.com/articles/s4159…

1/ Thrilled to share an advancement in gene therapy from my PhD in @NatureComms! We've developed a new approach to reduce immune responses while maintaining efficiency—paving the way for safer, more effective therapies. Big thanks to @zhangf & @mircoscopy! bit.ly/redicas9

Help is on the way! Ready to take stem cell technologies to the next level for drug development @CReM_Boston @GSK: Global Biopharma Giant GSK and BU/BMC Announce Collaboration to Pioneer New Lung Disease Treatments bu.edu/articles/2024/… @BUPulmonary @The_BMC @BUMedicine

Our paper on continuous mutagenesis in living cells using HACE is now out in @ScienceMagazine! We now demonstrate that HACE continuously generates mutations over a 10-day period and enables targeting using dCas9 without introducing DNA nicks. science.org/doi/10.1126/sc…

So excited to announce that the Kappel Lab will open at @UCLA @uclachem in July 2025! We’ll combine high-throughput experiments and computation to build predictive sequence-structure-function models of RNA, proteins, and their interactions. More here: sites.google.com/view/kappellab/

Today, we are announcing Future House, a philanthropically-funded moonshot focused on building an AI Scientist. Read our blog post here: futurehouse.org/articles/annou… and check out the @Bloomberg feature here: bloomberg.com/news/articles/… At Future House, our 10-year mission is to build…

We are hiring at all levels, please share, and reach out if you are interested in our work! (thestreckerlab.org)

In vivo Perturb-Seq reveals neuronal and glial abnormalities associated with Autism risk genes biorxiv.org/cgi/content/sh… #bioRxiv