Junyun Lai

Thrilled to share our article in @Nature showing that FOXO1 overexpression enhances CAR T cell persistence & metabolic fitness in treating solid cancers. Huge effort from @jack_chan15 @ChScheffler @I_mun0z, & co-led by @paulbeavis4, myself, & DarcyLab! rdcu.be/dEmg8

Thrilled to see our own @MarinaYakou in the #ASMRSpotlight! 🤩 Her research is tackling some big questions in cancer immunology—how patient-intrinsic factors like age, hormones and our microbiome influence antitumor immunity. @TheDohertyInst @TheASMR1

Our new study showing that resident memory T cell formation and phenotype varies across the length of the gut: sciencedirect.com/science/articl… @MucosalImmunol with @LMackayLab @maxevrard @UniMelb @TheDohertyInst

Honoured to be one of this year's @CancerResearch Institute's grant recipients. Incredibly grateful for their support of our important research on discovering new immunotherapeutic targets for breast cancer. @TheDohertyInst

Congratulations Prof Laura Mackay who has secured a prestigious @CancerResearch Institute (USA) grant to advance research into novel immunotherapy targets for breast cancer. The @LMackayLab is leading the way in tissue-resident memory (TRM) cell research and how these cells can…

Nature research paper: Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery go.nature.com/4le7GMB

NR4A2 & RGS16 promoters support delivery of cytokines (e.g. IL-12) directly to the tumor site, leading to enhanced antitumor efficacy and long-term survival of mice in both syngeneic and xenogeneic models @Nature @paulbeavis4 @_amandachen @emsderrick nature.com/articles/s4158…

CAR T cells are engineered to drive tumor-restricted expression of proinflammatory cytokines by repurposing endogenous gene regulatory mechanisms nature.com/articles/s4158… #NBThighlight

Happy to share a new study led by all-star team @_amandachen, @kahmin98, @ImranHouse, Phil Darcy and @paulbeavis4 showing that tumor site-specific delivery of potent cytokines is a safe way to boost CAR T cell treatment against solid cancers! nature.com/articles/s4158…

Exciting work from the Beavis and Darcy labs using endogenous promoters to drive tumor-restricted CAR T responses. Congrats @paulbeavis4 and team!

Dedicating my first post on X to share some exciting news — our work is out today in @Nature! 🎉 Co-first authored with the amazing lab buddy @_amandachen, and guided by our incredible supervisors @paulbeavis4, Phil & @ImranHouse. nature.com/articles/s4158…

Delighted to share our new approach to enhance CAR T cell function in solid tumours published today @Nature. In this work we identify a new strategy to generate armoured CAR T cells. nature.com/articles/s4158…

Excited to share that my PhD work is out in @Nature today! We engineered armoured CAR T cells to express therapeutic payloads only at the tumour site, to improve their safety and efficacy for the treatment of solid cancers. 1/14 nature.com/articles/s4158…

Excited to finally see this work in print! Big thanks to everyone who made it happen! 🔥 @TheDohertyInst @UniMelbMDHS For more, check out a related study from @hongbo_chi on pathways regulating gut TRM formation via nutrient sensing: cell.com/immunity/fullt…

1/ 🚨 Hot off the press! 🚨Our new paper, led by @ObersAndreas & @maxevrard, is now live in @ImmunityCP! 🧬 Curious how CD8+ tissue-resident memory T cells (TRM) adopt their fate in different organs? Let’s dive in! 🧵👇 authors.elsevier.com/c/1jw~j_OR~yiO…

CRI is proud to share the new cohort of Lloyd J. Old STARs! Meet the researchers who will receive $1.25 million over 5 years to drive high-risk, high-reward projects with the potential to transform cancer treatment and advance the frontiers of the field: bit.ly/3YAZIVd

🧬🔎Thrilled to share our latest findings on the epigenetic changes that occur post memory T cell development! Out today in @ImmunityCP! Incredible work led by @raissaf and Frank Buquicchio from team @Satpathology! 🧵👇 @TheDohertyInst @Unimelb @Stanford cell.com/immunity/abstr…

I am delighted to announce that I will soon join @TheCrick Institute in London! My lab will study how cancer affects the host "macroenvironment", especially the hematopoietic, cardiovascular, and immune systems. Sounds interesting? Join us! crick.ac.uk/research/labs/…

Bioengineered immune cells have been shown to attack and even cure cancer, but they tend to get exhausted if the fight goes on for a long time. Now, two separate research teams have found a way to rejuvenate these cells: make them more like stem cells. go.nature.com/4aIs42K

Nature research paper: FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy go.nature.com/3W0gziO

Excited to finally see this work come out online @NaturePortfolio. In this work we identify FOXO1 overexpression as a strategy to improve CAR T cell persistence and metabolic function using CAR T derived from mice, healthy donors and cancer patients. nature.com/articles/s4158…