Jiefu Li

Join us @HHMIJanelia for a unique event that brings together chemists, biologists and engineers to uncover the mysteries of the cell surface. 🔍🧬 #CellSurface #ChemicalBiology #ProteinEngineering Apply by May 20 @ janelia.news/SRF25 @ASCBiology @CellChemicalBiology

The #cellsurface is a hub of complex interactions where proteins, small molecules, and cells communicate. Join experts @HHMIJanelia to explore the latest research shaping our understanding of this critical interface! #cellbiology Apply by May 20 @ janelia.news/SRF25…

Excited to share this new work led by postdoc Brendan Floyd, deep mapping of cell-surface protein interactomes of T and B cells reveals maverick mitochondrial proteins and immune modulatory interactions. biorxiv.org/content/10.110…

Are you a #biologist looking to learn more about cell surface molecules? Apply today to attend a cross-disciplinary conference on the #biology and engineering of the cell surface at @HHMIJanelia (October 5-8). This @janeliaconf will: 🧪 Connect tool developers with biologists…

Excited to share our latest collaboration with Quan Yuan's lab at NIH: pnas.org/doi/10.1073/pn…

We are hiring a new lab manager! Our wonderful lab manager Albert is headed off to grad school and we are looking to fill his position this summer.  This is a great opportunity for a new graduate to spend a couple years immersed in research before applying to PhD or MD programs.…

So we beat on. Gene/cell therapies often use proteins that could be recognized/rejected as non-self by our immune system. We combine algorithms to build proteins that are therapeutically relevant and can masquerade as our own parts doi.org/10.1101/2025.0…

Today we report the directed evolution of HUH (a sequence-sequence covalent protein tag for ssDNA labeling) into rHUH, a sequence-specific covalent protein tag for RNA labeling. rHUH was hard to engineer: the initial HUH template had no RNA activity, so we started with RNA-DNA…

A cross-disciplinary conference dedicated to the cell surface @janeliaconf @HHMIJanelia to connect tool developers and biologists from diverse biology fields. Application deadline: May 20, 2025. (Bonus: golden season of the Shenandoah NP nearby!) @xinzhoulab @XinboYang777

Thrilled to share our collaborative work on the structural basis and myeloma disease link of the midnolin-proteasome pathway with @ChrisNardone95 from the Elledge lab @StephenE92884, Jingjing Gao from the Shao lab @sshaolab and all the co-authors! biorxiv.org/content/10.110…

1/ Excited to announce our new book, “Genetic Models of Down Syndrome”! This comprehensive guide explores diverse model systems—from invertebrate to vertebrate models—to advance our understanding of Down syndrome. #DownSyndrome #GeneticModels #Genetics @GDSFoundation @t21rs

Horsetail Fall, Yosemite National Park ✨

Tetanus on demand! (not for bioweapons, but for neuroscience research) Tetanus toxin induces paralysis by using a protease to cleave VAMP2, a protein required for synaptic vesicle fusion and neurotransmitter release. To harness this toxicity and use it as a beneficial tool for…

Congratulations to Liqun Luo. We are proud of your accomplishments and happy for you.

APEX peroxidase is a versatile tool for proximity labeling and electron microscopy (EM) but its requirement for toxic H2O2 is a liability. We now report LaccID, a multicopper oxidase evolved from an ancestral fungal laccase that oxidizes aromatic substrates using non-toxic O2…

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from transgene expression and real-time…

I learned so much from this guy.