Jason Ernst Lab

Genome-wide identification and analysis of recurring patterns of epigenetic variation across individuals: Communications Biology, Published online: 07 June 2025; doi:10.1038/s42003-025-08179-5Recurring genome-wide patterns of epigenetic mark variation… nature.com/articles/s4200…

A new paper: "Genome-wide identification and analysis of recurring patterns of epigenetic variation across individuals" led by Jennifer Zou and @eamaciejewski is now published. nature.com/articles/s4200…

A new paper: "Identifying associations of de novo noncoding variants with autism through integration of gene expression, sequence, and sex information" led by Luke Li is now published genomebiology.biomedcentral.com/articles/10.11…

Will comparative biology crack the epigenetic code to longevity? New imputed DNA methylation dataset covers 59 tissues from 348 mammals including long living species such as bowhead whale (211 years), bats, and the naked mole rat. Which tissue holds the key to longevity? Which…

A new paper "CMImpute: cross-species and tissue imputation of species-level DNA methylation samples across mammalian species" led by @eamaciejewski building on our lab's mammalian methylation array collaboration with @prof_horvath is now published genomebiology.biomedcentral.com/articles/10.11…

A new paper "ChromActivity: integrative epigenomic and functional characterization assay based annotation of regulatory activity across diverse human cell types" led by @tevzilla is now published. genomebiology.biomedcentral.com/articles/10.11…

Perspective on recent developments and challenges in regulatory and systems genomics academic.oup.com/bioinformatics… is out, amazing to think about this with @JuliaZeitlinger, @ferhatay, @mahonylab, @AMathelier, @AleMedinaRivera, @jernst98!

Here is a press release by ⁦@UCLAHealth⁩ that nicely summarizes the key findings from our paper published today ⁦@CellCellPress⁩. uclahealth.org/news/release/m…

Happy to share our new paper published today @CellCellPress. Thanks to all our coauthors from @dgsomucla, @UCLASemel, and CHDI. Distinct mismatch-repair complex genes set neuronal CAG-repeat expansion rate to drive selective pathogenesis in HD mice: Cell cell.com/cell/fulltext/…

Learning a Pairwise Epigenomic and Transcription Factor Binding Association Score Across the Human Genome biorxiv.org/cgi/content/sh… #biorxiv_bioinfo

Faculty Position in UCLA’s School of Medicine: Broad search in Biomathematics, Biochemistry, Genetics, Pharmacology, Neurobiology, Physiology, Microbiology, Immunology. We seek exceptional scientists committed to research and mentorship. Apply by Jan 19 recruit.apo.ucla.edu/JPF10062

After many zoom meetings, discussions & learning from one another about different ways to look at the same data/problem, our perspective article on regulatory genomics is out. We have a “hallmarks of gene regulation” figure which i am planning to use in my talks. Enjoy reading!

It was great taking part in writing this perspective on the cis-regulatory code with such excellent scientists. @iscb @ISCB_RegSys has provided us an outstanding platform to share and discuss these topics over the years. Let's keep up the great work in this fantastic community.

Delighted to have worked on this perspective on the cis-regulatory code with @JuliaZeitlinger, @JasonErnstLab, @ferhatay, @AMathelier, @AleMedinaRivera, @mahonylab, @sinhasaur arxiv.org/abs/2411.04363. We provide an overview of current progress and some challenges to think about.

New ‘Aging Clock’ Predicts the Maximum Lifespan of 348 Mammals Including Humans singularityhub.com/2024/06/07/a-n… via @Singularity Hub

"The maximal lifespan [of people and 347 mammalian species] is strongly associated with an epigenetic signature that is largely independent of sex, body mass, calorie restriction, or other lifestyle factors" @ScienceAdvances science.org/doi/full/10.11… @prof_horvath and colleagues

Identifying associations of de novo noncoding variants with autism through integration of gene expression, sequence and sex information biorxiv.org/cgi/content/sh… #biorxiv_genomic

This paper, a collaboration with @chongyuanluo, @jernst98, reports that mutations affecting methylation have a greater effect when occurring in higher CpG densities than in lower. cell.com/cell-genomics/…

Excited to say my preprint presenting CMImpute, a method to perform cross-species DNA methylation imputation, is out! @JasonErnstLab biorxiv.org/content/10.110…

Thank you to everyone involved in the RSG part of the conference! It is an honor to be able to host #rsgdream2023 at UCLA.