Dr. Jake Cashion

Our new paper published in @BrainBehavImm shows ablating pericytes in mice causes hypoactivity🏃, motor impairment, vessel dysfunction🩸, and widespread gliosis🌟. Another reminder of how important pericytes are for brain function. @BradASutherland @LabGlial (1/3)

The primary cells of the neurovascular unit: endothelial cells🔵, pericytes🦑 and astrocytes🟢 🦋

🔬Our #MultipleSclerosis Research Flagship was well represented at the Australian Society of Molecular Imaging @Au_Soc_Mol_Imag symposium last week with Prof Kaylene Young @LabGlial, A/Prof @BradASutherland, Dr @FletcherJL, @Jake_Cashion_ and @Tomlewis2310 all speaking #ASMI2024

Excited to share that our work showing the #mTOR inhibitor #rapamycin (Sirolimus) can reduce #brain #pericyte constriction following #stroke, is now published in Translational Stroke Research! link.springer.com/article/10.100…

Our group has some exciting, fully funded PhD projects but applications close 30th September, so if you are interested in epigenetics, neuroscience, cancer, molecular discovery and would like to learn some cool 2D and 3D epigenomic assays, this is your lab!

1/4 We are thrilled to announce that our 🌍 collaboration has resulted in a paper in @_JCBFM. @Gazz4_Science @CathFoster_ @BradASutherland @UTAS_ @SeattleChildrens @uni_copenhagen doi.org/10.1177/027167…

My group has a fully funded 3.5-year PhD position available in synthetic #organometallic #chemistry with a focus on highly reactive metal complexes for small molecule activation. #inorganic #ozchem Feel free to DM if you're interested! Apply here: utas.edu.au/research/degre…

Pericytes (CD13🟡) enwrap capillaries (lectin🔵), providing essential support for neurovascular function 🧠🩸 #FluorescenceFriday

Perivascular macrophages (LYVE1🟣) on blood vessels (CD31🔵) clearing out the brain 🧠 #FluorescenceFriday #neuroscience #immunohistochemistry

Excited to share our new preprint showing that the #mTOR inhibitor #rapamycin (Sirolimus) can reduce #brain #pericyte constriction following ischemia in vitro and #MCAO #stroke in vivo. biorxiv.org/content/10.110….

Pretty exciting day as I finally submit my PhD thesis! Just in time to jet off to the Gold Coast for #TSANZSRSASM2024 @tsanz_thoracic big thank you to everyone who helped me get here, now to wait for reviewers comments! #PhD #PhDSubmission @ResearchMenzies

Check out our new work on how microglia interact with the vasculature through astrocyte end feet using the @AllenInstitute #MICrONS cortical mm^3 dataset! Had a great time working with @Gazz4_Science, @BradASutherland and @SorenGrubb to produce this work!

1/ 🔥 Exciting findings from our collaboration between @UTAS_, @SeattleChildrens, and @uni_copenhagen! We've discovered a new way #microglia interact with 🧠 vasculature, which could reshape our understanding of their role in #brain health and disease. 🧵 biorxiv.org/content/10.110…

Transcriptomes, Proliferation & Contractility (Endothelin-1/Adenosine) of👤🧠vascular #Pericyte vs hiPSC-Pericyte (#Mesoderm vs #NeuralCrest) Does passage#(2~8) affect pericyte RNA/contractility😁 @NatKingScience @BradASutherland Stem Cell Res Ther 2024 stemcellres.biomedcentral.com/articles/10.11…

Our latest publication was just released in Stem Cell Research and Therapy, showing gene expression and functional differences between neural crest and mesoderm iPSC-derived pericytes (iPericytes). Check it out here: doi.org/10.1186/s13287…

Continued dysfunction of capillary pericytes promotes no-reflow after experimental stroke in vivo academic.oup.com/brain/article-…

We look forward to starting work on our NHMRC Ideas grant with @FletcherJL, @nickomatics, @BradASutherland and @BruestleLab. Together we will find out how MS-associated genetic variants alter brain cell function.

We're recruiting! Interested in how #mitochondria and #astrocytes regulate neuroinflammatory responses during demyelination? Our group is looking for a PhD student: shorturl.at/firvM Project uses transgenic mice, confocal microscopy and transcriptomics. Get in touch!