Jaime Grutzendler
@JGrutzendler
Neuroscientist and Neurologist @Yale / Cellular Mechanisms of Neurodegeneration / Glial-Vascular Biology / Translational Neuroscience / Intravital Microscopy
Cerebrospinal fluid links the brain and peripheral sensory system and drives headache in migraine with aura! We’re excited to share our newest article just published today in @ScienceMagazine . Please read along: science.org/doi/10.1126/sc…
thank you Alzforum for a clear and comprehensive commentary on our recent subcellular antibody based human brain proximity- based proteomics in Alzheimer disease
Subcellular proteomics reveals how #alzheimersdisease affects the myelin-axon interface. Spoiler alert: AD promotes aberrant signaling that likely dampens synaptic transmission. @Yale ow.ly/myTJ50WlcSR
New work from Yasmine Kamen shows that differentiating oligodendrocytes are filled with the zymogen procaspase-3. This provides a specific marker for new oligodendrocytes and suggests a role for this pathway in oligodendrocyte fate decisions. biorxiv.org/content/10.110…
congrats Rong
Thrilled to see our Patho-DBiT paper is on the cover of Cell 🤩🤩🤩. Also truly honored to be included in this focus issue celebrating 50 years of Cell focusing on molecular biology. Patho-DBiT enables the exploration of rich molecular biology in clinical patient FFPE tissue…
Super-excited to reveal our latest fluorescent voltage indicator, ASAP5, now online @NeuroCellPress! ASAP5 features higher responsivity and kinetics, allowing detection of single synaptic transmission events. The link gives free access until 2024.11.09: authors.elsevier.com/a/1joYd3BtfH9B…
Today in @ScienceMagazine, together with my former colleagues at NIBR, we report the discovery and characterization of first molecular glue degraders of the WIZ transcription factor (TF) for fetal hemoglobin derepression and therapeutic consideration in Sickle Cell Disease. 1/10…
