Ivan Ahel Lab
@IvanAhelLab
The application deadline has been extended for a postdoc position in our lab until August 22. Please enquire/apply if you are interested in ADP-ribosylation, ubiquitination, genome stability or immunity. my.corehr.com/pls/uoxrecruit…
A few years back we discovered a dual hybrid protein modification composed of ADP-ribose dinucleotide and ubiquitin (ADPr-Ub). Now we reveal that ADPr-Ub can be further ubiquitinated by the E3 ubiquitin ligase RNF114! nature.com/articles/s4146…
Really thrilled to see our paper out now in @NAR_Open: a new transcriptional repressor, RptR, that regulates type I restriction-modification systems! 🎉 Big thanks to @TangLabOxford, @_MarionSchuller, @IvanAhelLab, and @BlowerLab! doi.org/10.1093/nar/gk…
We have another postdoc position available to work on interplay between ADP-ribosylation and ubiquitination in regulation of genome stability. For this post expertise in cell biology is required. my.corehr.com/pls/uoxrecruit…
Our new paper describing the RNF114 protein as a reader of dual hydrid modification composed of ADP-ribose and ubiquitin (ADPr-Ub) we discovered a few years ago (collaboration with the lab of Gerbrand van der Heden van Noort) biorxiv.org/content/10.110…
A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in structural biology and biochemistry. The application deadline is June 20th. my.corehr.com/pls/uoxrecruit…
Call me a #ubiquitin geek, but this is genuinely one of the most exciting findings in recent years. Only came across Ub—ADPr a few years back with some pioneering @IvanAhelLab papers. New field emerging here, folks!
I'm excited to share the final version of this story published in @embojournal Check it out! embopress.org/doi/full/10.10…
I'm excited to share the final version of this story published in @embojournal Check it out! embopress.org/doi/full/10.10…
Attention PTM aficionados ‼️ Why have one PTM on a single amino acid when you can have two! We show that PARP10 mono-ADP-ribosylation is further ubiquitylated in cells! An exciting collaboration between the labs of @MichaelNADbio and @jnpruneda! Short thread below 🧵
Our discovery of reversing enzymes for RNA ADP-ribosylation reveals a possible defence protein module against toxic attack pubmed.ncbi.nlm.nih.gov/39970281/
Potential PhD students interested to work in our laboratory are welcome to apply through the ILESLA programme
Two weeks to go until the application deadline for ILESLA. If you or anyone you know would benefit from full funding to carry out a PhD in Life and/or Environmental Science please visit/refer to their website iles.web.ox.ac.uk/how-apply where you can see open day videos and guidance
We are pleased to inform you that the meeting “From Genome Instability to Cancer: A tribute to Angelos Constantinou” that will take place in Carry-Le-Rouet from March 10th to March 13th 2025 is now open for registration on the link: tribute2angelos.fr/page/home/
Our laboratory is looking for a postdoc with expertise in protein biochemistry and structural biology to work on novel pathways regulated by ADP-ribosylation of nucleic acids. Please RT.
Our new paper in collaboration with Luca Palazzo laboratory: authors.elsevier.com/sd/article/S14…
Our findings indicate that this synthetic lethal interaction is notably strengthened when paired with alkylating genotoxins. (3)
We're in the news. 😊 @JgmRack @IvanAhelLab @LeidenADPr @physorg_com phys.org/news/2024-10-s… doi.org/10.1016/j.jbc.…
Our team in Orléans (France) is looking for a new postdoc, to work closely with a research associate, Ibtissam Talhaoui, on a project focused on potential SUMO E3 ligases targeting the nucleosome. The details here: emploi.cnrs.fr/Offres/CDD/UPR…
Our new paper describing how tyrosine-linked ADP-ribosylation signalling is reversed. Big thanks to our collaborators @JgmRack, @LeidenADPr and @Lab_Matic. jbc.org/article/S0021-…
Here is the first paper out of my lab 🥳 A deep dive into a new class of macrodomains specific to bacterial and fungal pathogens. #AMR I'm super greatful to @DrAntonioAriza @IvanAhelLab @LeidenADPr and the other amazing people that help on this project! jbc.org/article/S0021-…
If you are interested in the regulation of interplay between ADP-ribosylation and lipoylation, check our collaborative paper. Congratulations to all authors, especially to our former postdoc Johannes for his first paper as an independent group leader! jbc.org/article/S0021-…
New job opportunity 📢 Associate professor, immunity/inflammation/infection (defined broadly) especially welcome Come and join a great community of supportive colleagues! Deadline 25 October, please spread the word path.ox.ac.uk/vacancy/associ…
Our new paper demonstrating reversible ubiquitylation of DNA and RNA: embopress.org/doi/full/10.10…