Marcin J. Suskiewicz
@MSuskiewicz
Structural biologist and biochemist. CNRS researcher at CBM Orléans. Interested in protein modifications & interactions. Also husband, dad of 2, friend, ☧.
Our recent article in Journal of Molecular Biology explores how Post-Translational Modifications (PTMs) orchestrate the repair of trapped Topoisomerase-induced DNA breaks via TDP1 and TDP2. sciencedirect.com/.../pii/S00222… @iacskolkata @IndiaDST @ICMRDELHI @DBTIndia
My brilliant friend @MartinLukacisin started his own systems biology lab and is looking for a PhD student or postdoc. Highly recommended!
In my recently found Systems Biology lab I have an opening for a PhD student/Postdoc to study the genetic basis of drug interactions in yeast. For more information & application info: lukacisinlab.github.io/vacancies
I’m happy to share our recent manuscript in which we are structurally and biochemically investigating 3'-5' tRNA splicing ligases, including a #cryoEM structure of the five-subunit D. rerio tRNA ligase complex. jbc.org/article/S0021-…
PhD position with our neighbours - a friendly team working on mRNA: abg.asso.fr/fr/candidatOff…
Thèse en glycochimie disponible dans notre équipe @ICOA_UMR7311 @Univ_Orleans @CNRSchimie @AgenceRecherche Si vous êtes intéressés, merci de postuler via le portail ADUM à cette adresse : collegedoctoral-cvl.fr/as/ed/voirprop…
Excited to share our latest on RNA polymerase I termination. Fantastic collaboration with @EPetfalski @MarieWinz @DTollervey online today in @CellReports cell.com/cell-reports/f… #DNA #RNA @IBBPAS Read next tweets to check out our key findings
What a heartening and inspiring thing to come across at the end of my walk to a meeting @UniofOxford.
Our perspective on Hsp90 as a global modifier of the genotype-phenotype-fitness map, along with its implications for evolution in nature and clinical settings, is now out in JMB. We review the existing literature, identify open questions, contextualize our recent findings on…
GPUs are *fast* at aligning protein sequences (and profiles!). 178x faster than JackHMMER! In ColabFold, 23x faster end-to-end compared to AlphaFold2 reaching the same accuracy! You get immediate speedups for all methods leveraging MSAs, from DCA, to PoET, and even AlphaFold3!
In my recently found Systems Biology lab I have an opening for a PhD student/Postdoc to study the genetic basis of drug interactions in yeast. For more information & application info: lukacisinlab.github.io/vacancies
Excited to share that the AlphaFold 3 model code and weights are now available for academic use. Looking forward to seeing what new research this unlocks and how the research community builds on AlphaFold 3 for scientific discoveries github.com/google-deepmin… 1/2
Imagine a dataset where it's the whole of the AlphaFold Database but you can pull-out the domain-like structures avoiding random spaghetti, or get all the domain-domain interactions, or check whether domains match a known structural super-family. That's TED:
TED: The Encyclopedia of Domains now published in @ScienceMagazine discovering and annotating 314 MILLION protein domains in the AlphaFold database. joint work of @CATH_Gene3D and @psipred here at UCL.