Science Translational Medicine
@ScienceTM
The mission of Science Translational Medicine (AAAS) is to promote human health by communicating leading research and policy in biomedicine.
The new issue of #ScienceTranslationalMedicine is out now! A drug for rheumatoid arthritis shows signs of boosting the anticancer capabilities of immunotherapy in a clinical trial, a new Review explores the molecular hallmarks of hydrocephalus, and more. scim.ag/43IRnzD
Antibodies against the #dengue EDE correlate with milder disease and neutralization against all 4 serotypes and may offer a correlate of protection, shows a longitudinal study of children in the Philippines during the #DengVaxia campaign. @MpingaboPatrick scim.ag/4oaG9xx
The new issue of #ScienceTranslationalMedicine is out! Immunity to 2009 pandemic swine fly can protect ferrets from H5N1, a study of children in the Philippines identifies antibodies against dengue that could be a correlate of protection, and more. scim.ag/4msrRqr
Mismatches in #SIRPA alleles between donors and recipients of #KidneyTransplant correlate with poorer outcomes and a higher risk of chronic rejection, indicating SIRPA genotyping could benefit current monitoring protocols. @InstituteStarzl scim.ag/4lA6Euv
mRNA or adenovirus flu vaccine boosters produce strong immune responses against H1N1 and match the efficacy of a live-attenuated booster in macaques, supporting their potential as a more flexible platform for #influenza vaccines. @BarouchLab @BIDMChealth scim.ag/45Zjb5M
Pre-existing immunity to the 2009 #H1N1 influenza virus can partially protect against both infection and severe symptoms from subsequent exposure to #H5N1 virus, according to new experiments in ferrets. @SageVle @VBSatPennState scim.ag/4f4EK7j
Engineered “RNACaps” provide oral delivery of liquid #mRNA therapeutics to the intestines in small and large animals for the treatment of #colitis and could support the clinical translation of oral mRNA therapies. @WeiTaoLab @BrighamAnes @XiangangHuang scim.ag/3IwtODi
mRNA or adenovirus flu vaccine boosters produce strong immune responses against H1N1 and match the efficacy of a live-attenuated booster in macaques, supporting their potential as a more flexible platform for #influenza vaccines. @BarouchLab @BIDMChealth scim.ag/45Zjb5M
The complement arm of immunity is a major driver of acute chest syndrome in #SickleCellDisease, shows new work involving mice and patient samples that also reveals targeting C5 can alleviate lung damage in vivo. @Stowell_lab @ATLPedsHemOnc scim.ag/40qfRgn
Engineered “RNACaps” provide oral delivery of liquid #mRNA therapeutics to the intestines in small and large animals for the treatment of #colitis and could support the clinical translation of oral mRNA therapies. @WeiTaoLab @BrighamAnes @XiangangHuang scim.ag/3IwtODi
The new issue of #ScienceTranslationalMedicine has arrived! Engineered capsules can deliver liquid mRNA therapeutics to treat intestinal disease in animals, the complement cascade offers a target in acute chest syndrome in sickle cell disease, and more. scim.ag/44Ut82f
Macrophages resolve inflammation and ischemia-reperfusion injury after #LiverTransplant by acting through the receptor MAS to clear out aged neutrophils, according to new work involving mice and patient samples. @TongjiMaleHospi scim.ag/46FTQOv
A new series of #quinazoline compounds can neutralize #Tcruzi and related parasites by targeting the enzyme KRS1 and has partially efficacy in mice with acute #ChagasDisease, according to a new proteomic and structural analysis. @LabWyllie @WCAIRDundee scim.ag/4nJm6pF
A modeling analysis of patients with clade I #mpox in the DRC identifies stratification groups and early markers that predict lesion length and severity, which may inform research into tailored therapies and control measures for outbreaks. @NU_GS_Science scim.ag/3I61N5z
mRNA or adenovirus flu vaccine boosters produce strong immune responses against H1N1 and match the efficacy of a live-attenuated booster in macaques, supporting their potential as a more flexible platform for #influenza vaccines. @BarouchLab @BIDMChealth scim.ag/45Zjb5M
This week's issue of #ScienceTranslationalMedicine has arrived! Flu vaccine boosters based on mRNA or adenoviral technology provide strong immunity against influenza in large animals, quinazolines show promise against Chagas disease in mice, and more. scim.ag/4eY4AKt
An atlas of #synovial tissues in juvenile idiopathic arthritis (#JIA) reveals distinct cellular niches that correlate with joint inflammation and disease-associated genes, and could inform future targeted therapies. @WedderburnGroup @UCLchildhealth scim.ag/400GgRI
Why do wounds in the mouth heal without scars? New work shows that oral fibroblasts suppress #fibrosis through the proteins AXL and GAS6, and finds stimulating AXL recapitulates these benefits in facial skin wounds in mice. @LongakerLab @StanfordPlastic scim.ag/40oWioT
Older patients with #lupus display a marked drop in the expression of #interferon stimulated genes and shifts in methylation #epigenetic patterns, according to a clinical study that may explain why the condition becomes milder with age. @UCSF_ID scim.ag/44w02Gm
A new genome-wide #CRISPR screen identifies BACE1 as a driver of lung cancer #metastasis to the brain, suggesting that BACE1 inhibitors could be repurposed to prevent brain metastasis in #NSCLC. @sheilasinghlab @McMasterSurgery scim.ag/4eyJwtG
A modeling analysis of patients with clade I #mpox in the DRC identifies stratification groups and early markers that predict lesion length and severity, which may inform research into tailored therapies and control measures for outbreaks. @NU_GS_Science scim.ag/3I61N5z
