Ian Parish
@IanParish_AU
Immunologist & Group Leader @PeterMacCC. Views are my own.
We’ve known about tolerant CD8+ T cells for >25 yrs – but what are these cells?! Prematurely exhausted, stalled effectors, or something else? Our latest @ImmunityCP paper takes a deep dive into this question with some unexpected results, including a link to cancer… (1/)
Online now: The CD8+ T cell tolerance checkpoint triggers a distinct differentiation state defined by protein translation defects dlvr.it/T7BsSt
Why do some people succumb to severe respiratory diseases? Our study at @CellCellPress defines how OLAH, a key fatty acid enzyme, drives severe respiratory viral infections @KatherineKedz @chua_brendon @theJCClab @TheDohertyInst cell.com/cell/fulltext/…
Thrilled to share new work led by @JieYang437 in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre rdcu.be/eci1U
Register for the 2025 Mini Symposium to hear talks from Prof Ralf Adams, @SanjayPatelMD, @IanParish_AU and @CGerlach_lab. Taking place on 26 March and free for ISEH members, you can register here: iseh.org/2025MiniSympos…
Check out our latest paper in @ImmunityCP, “Identification of indirect CD4+ T cell epitopes associated with transplant rejection provides a target for donor-specific tolerance induction”, led by an amazing PhD student @Zhuldyz_Zhanzak.
science.org/doi/10.1126/sc… First paper from the @JohnstoneLab for the year and a brilliant collaboration with @TheDohertyInst colleagues Dan Utzschneider and Alex Kallies. Thanks to all @PeterMacRes @PeterMacCC for help and support and great job Dane Newman and Leonie Cluse!
Opportunity for a bioinformatician to join the lab @PeterMacRes to help us identify new Immunotherapies. Please reach out for further details. Ad is for a post doc but research assistants considered. 💻 🧬. See link below.
I've been on a Twitter moratorium for the last week given the.. news, but I'm happy to announce a new story from our group @NatImmunol describing a metabolic sensitivity of exhausted T cells to lactic acid in tumors! 1/ nature.com/articles/s4159…
Check out our latest paper “Differentiation fate of a stem-like CD4 T cell control immunity to cancer”, led by @Maria_Carden1 now live @Nature tinyurl.com/33d24k89 . This work examines how CD4 T cell differentiation dictates the outcome of the cancer response. Thread below
Come and join us! We are looking for a bioinformatician to join the lab. Work with single cell, multiome and spatial data from model systems and human samples! Our focus is lymphatics and blood brain barrier in development, regeneration and cancer. seek.com.au/job/79558172
What a week with two publications from our lab! Spatial microniches of IL-2 drive lung migratory Th2 cells to allergens in NI & a review on Systems Immunology Approaches to studying T cells in npj Systems Biology. nature.com/articles/s4159…
We have an open postdoc position in my group! The projects of the lab are focused on understanding how cancer genomes dictate immune responses, tumor evolution, and therapy resistance. Come join us in a great environment! vhio.net/2024/09/18/ref…
Our latest paper "NaCl enhances CD8+ T cell effector functions in cancer immunotherapy" is now out @NatImmunol nature.com/articles/s4159… 🥳🎉🍾. A 🧵:
Very happy to share this new work on LAG3 and PD1. Has been a long road to (begin to) sort out how LAG3 functions in CD8 T cell exhaustion. Great work by Shin Ngiow and super collaboration (and 2 other great papers) with @Vignali_Lab and Dario Vignali cell.com/cell/abstract/…
Definitely an amazing 2 days of immunology! Always exciting to chat with and learn from colleagues and experts in the field. 🧑🔬🙌 Thank you to @ImmunoGroupVic for organising this awesome meeting and giving us the chance to share some of our work.
And that’s a wrap! A phenomenal two days of science data and discussion. A big congrats to our best oral and poster presentation winners! Some amazing work being done in Victorian and Tasmanian immunology, already can’t wait for next year 💉🥼🧫
Exciting new paper from @divijmathew highlighting the ability to drug the "immunopharmacology" of checkpoint blockade to improve responses in NSCLC. aPD1+transient JAK inhibition. A great collaboration with @andyjminn. Similar work from J.Teijaro @scripps …w-science-org.proxy.library.upenn.edu/doi/pdf/10.112…
Job alert! We are recruiting a research associate to join our lab! The position involves a combination of lab and mouse colony management and designing and performing experiments with a talented and collaborative team of cancer researchers. Please RT! ummsjobs.com/job/10416/
Big thanks to Katharine Block & Steve Jameson @Jamequistlab for this brilliant and thoughtful commentary on our recent @ImmunityCP paper. You’ve summarized it better than I could! cell.com/immunity/abstr…
Thanks for hosting Rahul - really enjoyed the visit and the fantastic science discussions. Looking forward to many future collaborations as a result of this visit.
Thrilled to be hosting the brilliant Ian Parish @IanParish_AU who will talk about "Early regulation of T cell activation" at our BSI Cambridge Immunology Group seminar series today. 12:30 @CamPathology and online. Free pizza for students and post-docs! @BSICambridge