The Hornberger Lab
@HornbergerLab
Our lab uses a variety of molecular techniques to define how mechanical signals regulate skeletal muscle mass
1/10 Excited to write this thread summarizing our new paper in @NatMetabolism, which identifies a potentially critical part of the signaling pathway that drives skeletal muscle growth in response to resistance exercise! Free link rdcu.be/el9am #Myotwitter @NIH_NIAMS
Great points are raised in this 5 min read. Plan to restructure NIH would stall science, not streamline it thehill.com/opinion/health…
The titin N2A-MARP signalosome constrains muscle longitudinal hypertrophy in response to stretch biorxiv.org/content/10.110…
Hey Muscle And Metabolism Folks on Twitter, @LykkeSylow and I are looking for a Postdoc who is interested in applying for a prestigious @DDEA_Denmark fellowship with us. More details in the picture attached. Please share widely! @MYOTWlTTER
Interesting new @NatureComms paper: Early-life exercise extends healthspan but not lifespan in mice. tinyurl.com/29v6j4x4
Time-of-day effect of high-intensity muscle contraction on mTOR signaling and protein synthesis in mice | Scientific Reports nature.com/articles/s4159…
Conference: Inter-individual variation in exercise. Please join! The speakers include e.g. @mackinprof @AbigailMackey1 @MarcasBamman @HornbergerLab @DrMikeRoberts @BradSchoenfeld @MarkusPerola G Nader, E Sillanpää, A Hecksteden, W Derave, P Atherton! tinyurl.com/34xzsdss
📢The Integrative Muscle Plasticity Lab @UF_HHP is seeking graduate students (MS/PhD) & staff for Fall 2025 / Spring 2026. No prior background in muscle needed – just curiosity & drive. 🔁 Please share or tag someone interested. #Myotwitter #PhDPositions @UFMyology @UFBreathe
Soo pumped to see this paper online! Much of my work over the past 3 years. Fitting to be ending my time at @UKYCMB with this one- I learned a lot, made new collaborations, and it led to important discoveries and data for the field #myotwitter sciencedirect.com/science/articl…
Online now: AKT-mediated phosphorylation of TSC2 controls stimulus- and tissue-specific mTORC1 signaling and organ growth dlvr.it/TLBR9Q
If you're interested in knowing more details about the proposed FY2026 budget for each of the proposed NIH institutes, then go to the link below. Warning..... It's bad.... really really bad. herehttps://officeofbudget.od.nih.gov/insti_center_subs.html
Here is where your institute/center at NIH would go under the proposed restructuring plan. For the NIAMS folks, you would now go to the National Institute of Body Systems and the collective institutes in there would experience at 30% budget reduction (better than the 40% average)
Post doc opportunity with Karyn Esser @UF working on the SOMMA project! Reach out to her if you are interested.
The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan nature.com/articles/s4358…
This looks awesome. Can’t wait to give it a careful read.
Amazing to see this collaboration paper in @CellPress @CellReports Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through large-scale multi-omics integration! Led by @nir_eynon & @MacsueJ cell.com/cell-reports/f…
#myotwitter
@aga_borowik, @KevinMurachPhD and Miller explore myonuclear replication, myonuclear domain dynamics, and myonuclear mobility and shape as a new direction for understanding muscle mass maintenance in this #BiochemSocTrans mini-review. doi.org/10.1042/BST202…
It was a pleasure & a privilege to work with @scbodine on this 'News and Views' piece for @NatMetabolism highlighting new @HornbergerLab work on mechanically-sensitive MKK3b/6, p38, MK2, mTORC1 signaling mediating resistance exercise-induced muscle growth nature.com/articles/s4225…