Matthew S. Alexander

@Matt_Muscle_Guy

Geneticist, Skeletal Muscle, Drug development, Gene therapies. Non-coding RNA, and Zebrafish Aficionado. All tweets are my own. Instagram @thealexanderlab

Birmingham, AL

Joined March 2014

4KFollowing

5KFollowers

Matthew S. Alexander@Matt_Muscle_Guy · Jul 26

New @NatureComms paper: SMCHD1 maintains heterochromatin, genome compartments and epigenome landscape in human myoblasts. tinyurl.com/bubedsza

Matt_Muscle_Guy's tweet card. Nature Communications - The authors characterize SMCHD1 as a nuclear lamina-associated protein in human myoblasts where it serves as an anchor for heterochromatin. Loss of SMCHD1 leads to B-to-A...

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Matthew S. Alexander@Matt_Muscle_Guy · Jul 26

New #SkeletalMuscle paper: Large MAF transcription factors reawaken evolutionarily dormant fast-glycolytic type IIb myofibers in human skeletal muscle. tinyurl.com/munak989

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Matthew S. Alexander@Matt_Muscle_Guy · Jul 24

New @CellRepMed paper: Opantimirs: A class of antagonizing microRNAs that upregulate Opa1 and improve mitochondrial and disuse myopathies. tinyurl.com/2sbc95br

Matt_Muscle_Guy's tweet card. Djalalvandi et al. show that blockers of Opa1-targeting microRNAs found upregulated in diseased skeletal muscle can restore mitochondrial architecture and muscle performance in mitochondrial myopathy...

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Matthew S. Alexander@Matt_Muscle_Guy · Jul 23

New @EmboMolMed paper with our accompanying news and views on: MicroRNA-33 inhibition ameliorates muscular dystrophy by enhancing skeletal muscle regeneration. tinyurl.com/43cyhfz2

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Matthew S. Alexander@Matt_Muscle_Guy · Jul 17

Interesting new @Dev_Cell paper: Microtubules coordinate mitochondria transport with myofibril morphogenesis during muscle development. tinyurl.com/3j29y6aw

Matt_Muscle_Guy's tweet card. Avellaneda et al. identify that kinesin-dependent transport is required to relocate mitochondria into close proximity to the assembling myofibrils in Drosophila and mouse muscles. Microtubules are in...

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Matthew S. Alexander@Matt_Muscle_Guy · Jul 17

New @MolTherapy paper: AAV-microutrophin gene therapy confers long-term cardioprotection against pharmacologic and exercise-induced injury in dystrophin deficiency. tinyurl.com/ypdkckmc

Matt_Muscle_Guy's tweet card. AAV-microutrophin gene therapy confers durable cardioprotection during heightened cardiac workload in the Duchenne muscular dystrophy mouse. In novel drug- and exercise-induced cardiac stress assays,...

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Matthew S. Alexander@Matt_Muscle_Guy · Jul 12

New #Oncogene journal paper: The tumor suppressor pRb and its relative p130 are required to maintain murine adult skeletal muscle homeostasis. tinyurl.com/4j64jvy6

Matt_Muscle_Guy's tweet card. Oncogene - The tumor suppressor pRb and its relative p130 are required to maintain murine adult skeletal muscle homeostasis

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Matthew S. Alexander@Matt_Muscle_Guy · Jul 11

Congrats to Mike Lopez and other lab members and collaborators on our new #JCSM paper: Late-Stage Skeletal Muscle Transcriptome in Duchenne Muscular Dystrophy Shows a BMP4-Induced Molecular Signature. #DMD tinyurl.com/ms7w9n8c

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Matthew S. Alexander@Matt_Muscle_Guy · Jul 10

New #MolTherMethClinDev paper: Enhanced therapeutic potential of a microdystrophin with an extended C-terminal domain. tinyurl.com/y43m53h5

Matt_Muscle_Guy's tweet card. Microdystrophins are miniaturized versions of dystrophin, used in AAV gene therapy of Duchenne muscular dystrophy. Danos and colleagues describe an enhanced microdystrophin with a C-terminal extens...

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Matthew S. Alexander@Matt_Muscle_Guy · Jul 10

Interesting new @NatureComms paper: Early-life exercise extends healthspan but not lifespan in mice. tinyurl.com/29v6j4x4

Matt_Muscle_Guy's tweet card. Nature Communications - Exercise exerts health benefits, yet the long-term effects of early-life regular exercise on later-life health and lifespan remain poorly understood. Here, the authors show...

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Matthew S. Alexander@Matt_Muscle_Guy · Jul 10

Congrats to @LorsonLab and colleagues for their new @hmg_journal paper: Novel neurofilament light (Nefl) E397K mouse models of Charcot–Marie-tooth type 2E (CMT2E) present early and chronic axonal neuropathy. tinyurl.com/y9x94c8z

Matt_Muscle_Guy's tweet card. Abstract. Charcot–Marie-Tooth (CMT) is the most common hereditary peripheral neuropathy with an incidence of 1:2500. CMT2 clinical symptoms include distal

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Matthew S. Alexander@Matt_Muscle_Guy · Jul 10

Congrats to @jyoti_k_jaiswal, James Novak, and colleagues on their new #CellDeathDis paper: Failure to resolve inflammation contributes to juvenile onset cardiac damage in a mouse model of Duchenne muscular dystrophy. tinyurl.com/57p7p588

Matt_Muscle_Guy's tweet card. Cell Death & Disease - Failure to resolve inflammation contributes to juvenile onset cardiac damage in a mouse model of Duchenne muscular dystrophy

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Matthew S. Alexander Retweeted

Craig A. Goodman@CraigAGoodman1 · Jul 9

Transcriptional Diversity in Response to Aging Across Skeletal Muscles onlinelibrary.wiley.com/doi/10.1111/ac…

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Matthew S. Alexander@Matt_Muscle_Guy · Jul 9

New @hmg_journal paper: A discrete region of the D4Z4 is sufficient to initiate epigenetic silencing. #FSHD tinyurl.com/yfs5nnbn

Matt_Muscle_Guy's tweet card. Abstract. The DUX4 transcription factor is briefly expressed in the early embryo and is epigenetically repressed in somatic tissues. Loss of epigenetic rep

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Matthew S. Alexander Retweeted

Juleen R. Zierath@JuleenRZierath · Jul 8

Our latest: HIF1α mediates circadian regulation of skeletal muscle metabolism & substrate preference in response to time-of-day exercise - HIF1α regulates time-of-day-specific metabolic adaptations, integrating circadian & energetic-induced signals. pnas.org/doi/10.1073/pn…

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Matthew S. Alexander@Matt_Muscle_Guy · Jul 8

New @JCI_insight paper from Villalta and Spencer labs: Macrophage-derived Spp1 promotes intramuscular fat in dystrophic muscle. tinyurl.com/hrwfrkus

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Matthew S. Alexander@Matt_Muscle_Guy · Jul 7

New #SkeletalMuscle paper: Abnormalities in the genioglossus muscle and its neuromuscular synapse in leptin-deficient male mice. tinyurl.com/22n3jx9d

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Matthew S. Alexander@Matt_Muscle_Guy · Jul 6

New @NatureComms paper: Multiomics and cellular senescence profiling of aging human skeletal muscle uncovers Maraviroc as a senotherapeutic approach for sarcopenia. tinyurl.com/yzkepbyb

Matt_Muscle_Guy's tweet card. Nature Communications - This study leverages single-nucleus multiomics to map cellular senescence atlas in aging human skeletal muscle and uncovers potential targets and senotherapeutics for...

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Matthew S. Alexander Retweeted

Craig A. Goodman@CraigAGoodman1 · Jul 2

Evaluating skeletal muscle wasting and weakness in models of critical illness portlandpress.com/clinsci/articl…

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Matthew S. Alexander@Matt_Muscle_Guy · Jul 3

Some good news amidst the chaos, my lab officially received our notice of award for a #DoD CDMRP DMD grant focused on evaluating new therapies that impact DMD neurological symptoms. Excited to work on this project with Karen Gamble’s lab in UAB Psychiatry.

Matt_Muscle_Guy's tweet image. Some good news amidst the chaos, my lab officially received our notice of award for a #DoD CDMRP DMD grant focused on evaluating new therapies that impact DMD neurological symptoms. Excited to work on this project with Karen Gamble’s lab in UAB Psychiatry.

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