Poom Khunsriraksakul 🇹🇭

🚨 Antispasmodics in IBD: More harm than help? In a massive study of 85K+ patients, these drugs were linked to: ⚠️ More abdominal pain ⚠️ Increased opioid initiation ⚠️ Higher ER & hospital visits 🔗 doi.org/10.1111/apt.70… #IBD #Gastroenterology #MedTwitter @APandT

I am thrilled to share one of the most important projects from my PhD! We developed the method JOBS (JOint model of Bk-eQTLs as a weighted sum of Sc-eQTLs) and applied it to blood bulk (eQTLGen) and sc-eQTL (OneK1K). 1/3

I am excited to share our new work that generates a single cell eQTL atlas for immune cell types. The work integrates bulk eQTLs with sc-eQTLs, which boosts the power for identifying sc-eQTLs for up to 4 folds. As such, we have the power equivalent to sc-RNASeq of 4K individuals.

Check out our latest work on Genetic Progression Score (GPS) to predict the progression of autoimmune diseases from preclinical stages. Work led by @ChenWang_PSU and @MarkusHavell.

Happy Holidays from our Longcope family to yours🎄 @OslerResidency

Just a couple Longcope #strongcope physician scientists rocking the MTL service @GUTomics #mdphd #doubledocs

So excited to welcome the newest members of the Longcope Firm to the @OslerResidency #strongcope 💪❤️

It’s almost July 1! Can’t wait to see this amazing new group of Osler interns grow and take fantastic care of patients under the leadership of their ACSs! #Oslerpride

Excited to share our latest work in @NatureComms. We extended our previous PUMICE's framework (nature.com/articles/s4146…) to allow the utilization of publicly available single-cell eQTL summary statistics. Kudos to @LD_matrix and @dajiangliu81 for leading this important work.

Real-World Data: Applications and Relevance to Cancer Clinical Trials pubmed.ncbi.nlm.nih.gov/37684067/ We compare randomized trials to retrospective data from US national cancer databases (eg, SEER, NCDB). @C_PisanoDO @GUTomics @DrSpratticus @HenryParkMD @yilun_sun @mwang_cwru

We used the awesome PUMICE software from @GUTomics to build predictive models for kidney gene expression and found 399 genes with evidence of a causal link to BP

Can you use multiomic data from the kidney to identify new therapeutic and diagnostic targets with a causal link to blood pressure? Our work out now in @NatureComms rdcu.be/dBJT4 tl;dr = Yes Interested in more? see below

And the Osler Family grows!! Thrilled to welcome these fantastic future physicians to the Osler Medical Residency, and excited to see all they accomplish as they become master clinicians and shape medicine. It’s a great day in the Osler Medical Residency! MUCH #oslerpride

The ability of glioblastoma cells to diffusely invade into healthy brain contributes to the deadliness of this cancer. We are excited to share our latest finding that iron may play a role in this crucial aspect of GBM cell biology - now out in FASEB J: faseb.onlinelibrary.wiley.com/doi/full/10.10…

Super excited a series of THREE @UKBIOBANK #proteomics papers are now online on @Nature! nature.com/articles/s4158… - flagship paper and two sister companion pieces: nature.com/articles/s4158… and nature.com/articles/s4158… - Herculean team effort across so many teams! More to follow.