Pedro Ortega

📢 For all HaloTag lovers💙💚💛❤️💜🩶 we are excited to share that our work, in which we developed a new biotin-HaloTag ligand, is now published in @JCellBiol! Full link here: rupress.org/jcb/article-ab…

Hi there! We are lookig for a highly motivated and talented postdoctoral researcher to join our dynamic team starting in 2026. Please see the call for more details! Come on join us! It will be fun! :)

Online Now: The DNA replication checkpoint prevents PCNA/RFC depletion to protect forks from HLTF-induced collapse in human cells dlvr.it/TLZtS1

Happy to introduce AlphaGenome, @GoogleDeepMind's new AI model for genomics. AlphaGenome offers a comprehensive view of the human non-coding genome by predicting the impact of DNA variations. It will deepen our understanding of disease biology and open new avenues of research.

New paper out! We provide a computational tool for the prediction of cell type specific R-loops. A nice collaboration with⁦ @DatalabUPO @ThomasVanhaeren doi.org/10.1093/nargab…

In our latest paper, we uncover condensin II as a novel BLM interactor critical for genome stability in S phase. Condensin II contributes to BLM localization at active forks and undergoes a transient structural change in S phase.nature.com/articles/s4200…

Wondering what is a nucleoporin doing at repair sites? Check it out in our most recent paper in Molecular Cell! dlvr.it/TLBMbH

We describe how to perform Oligo-seq, a new method to map DNA motifs targeted by base editors. Validated with APOBEC3A and APOBEC3B, but adaptable to AID, CRISPR-Cas9, and more. 🧬 Full protocol 👉 sciencedirect.com/science/articl… Thanks to @RemiBuisson @AmbrocioSanchz at @UCIrvine!

Our latest study from my postdoctoral work has just been published in @ScienceAdvances. Grateful to my mentor and collaborators who made it possible! @RemiBuisson @ElodieBournique @AmbrocioSanchz @UCIrvine @abbygreenlab @J_Maciejowski 🔗 science.org/doi/10.1126/sc…

🥳 Out now @embojournal! Interferon induces a new class of p62 bodies, with antiviral & immunotherapy implications. p62 is usually linked to autophagy—but not here. These are driven by PARP14-mediated ADP-ribosylation & rely on ubiquitin-proteasome system. embopress.org/doi/full/10.10…

Glad to see our PACT preprint published in @NatureComms! "Cooperative role of PACT and ADAR1 in preventing aberrant PKR activation by self-derived double-stranded RNA" Another step forward in understanding innate immunity. @UCIrvine @RemiBuisson 🔗 nature.com/articles/s4146…

RNA polymerase II processing facilitates DNA repair and prevents DNA damage-induced neuronal and developmental failure biorxiv.org/content/10.110… #biorxiv_molbio

💡PARP enzymes regulate ADP-ribosylation, a protein modification linked to cancer, viral infections & neurodegeneration. It has two forms—MARylation (single) & PARylation (multiple). dELTA-MS identifies both in one experiment! pubs.acs.org/doi/full/10.10…

POSTDOC position available in my group @cabimer @unisevilla . Please spread the word! Contact: [email protected]

Another molecular feat from my colleagues in my previous lab @kaistpr led by a talented PhD student, Keonyong Lee, and postdoc @jayoungku9. Nuclear Retention and RNA Editing Suppress the Recognition of Undegraded Intron Lariats as Non-Self papers.ssrn.com/sol3/papers.cf…

Carcinogens in tobacco smoke leave the genome vulnerable to deamination by viral restriction factor APOBEC3B. This new pattern of mutations known as “Didyma” can help delineate the origins a different cancers. Check out the full Pre-Print here: biorxiv.org/content/10.110…

Congratulations Jenna Whalen on her Nature Cancer pub out today- nick toxicity linked to resection! rdcu.be/d60Td

The start of the lab's APE1 efforts - more to come: AP endonuclease 1: Biological updates and advances in activity analysi... sciencedirect.com/science/articl… @BrownMedicine @BrownUniversity @BrownUCancer @Brown_SPH

1/ 🚨New paper on ecDNAs from our lab! We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! 🧵👇 nature.com/articles/s4158…

Online Now: Repair of replication-dependent double-strand breaks differs between the leading and lagging strands dlvr.it/TGYr69