Sarah Boyle 👩🏻‍🔬🎀

My sole author review "Hormonal Regulation of the Breast Cancer Microenvironment" is out in its final (free) form at @JMolEndo as part of the Rising Stars collection. jme.bioscientifica.com/view/journals/… Thanks @simakali1 for the invitation!

A bit late to the party, but finished Lessons in Chemistry by Bonnie Garmus. POV as a reader: captivating, funny, gripping story, relatable in professional sense. As a woman in science: Fantastic to see how far we’ve come, but some aspects still unfortunately resonate. Recommend!

Interested in a #postdoc on cardiac #mechanobiology? Our lab has a fully funded position via our recently awarded @HFSP grant to study the biophysical processes that build insect hearts🪲🪰🫀 Come join us @MBIsg for some cool evo-devo-mechanobio work! 👇 mbi.nus.edu.sg/jobs/seeking-p…

Finally got the time to put together my awesome new Lego, The Evolution of STEM 🧬🔬🧪🚀

There’s tons out there about fibroblast #mechanobiology in disease. In @ConfinementLab’s new review in @aplbioeng, Yeji gives you the who/what/where/when/how/why of mechanosensitive fibroblast activation, from CAFs to FAFs and nearly everything in between! pubs.aip.org/aip/apb/articl…

Someone born in 1990 is up to three times more likely to be diagnosed with #BowelCancer than someone born in 1950. Early onset bowel cancer is increasing globally and @UniversitySA & @CCB_Research scientist Prof Michael Samuel is on a quest to find out why brnw.ch/21wTD2l

It’s finally out!!🥳 Check out our paper in @NatureMaterials on a new hybrid scaffold where we discover ECM-specific cues that regulate cardiac aging 🔗 nature.com/articles/s4156… This is the lab’s 1st research paper, led by my 1st @NUSBME PhD student @AveryRuiSun🤩 Tweetorial👇

Thank you @MaraShermanLab for this insightful spotlight on our recent paper in @CD_AACR ! Love the title too 😍 - CAFs Defang NK Cells to Promote Breast Cancer Immunosuppression …crjournals-org.ezproxy.weizmann.ac.il/cancerdiscover…

🧫 Researchers demonstrated that ECM stiffness is significantly higher in endometrial cancer tissues compared to normal endometrium, correlating with elevated expression of ROCK1, a mechanosensitive kinase. @cddpress | go.nature.com/3YL7Hyt

How do altered levels of lamins and other nuclear envelope proteins contribute to cancer metastasis, and how does this relate to #mechanobiology? Learn more in our recent review by @SarahHenretta now out in @Nature_NPJ - biological physics and mechanics (doi.org/10.1038/s44341…).

Come work with us! Seeking a Research Associate/Fellow to work on our NHMRC funded project using nanofabrication to model tumour ECM structures. @CCB_Research

Choking under pressure? 🥵 3D confinement in hydrogel-based culture inhibits muscle stem cell activation and differentiation. “…this #preprint demonstrates the interconnectedness of different subfields of biology.” #preLight of @JustinGutBio ⬇️👀 prelights.biologists.com/highlights/3d-…

Our latest paper on #cardiac #fibrosis is out today in @Nature. Congrats to @StanfordCVI @StanfordMed researchers led by @Sangkyun_Cho and @SiyeonRhee. And special thanks to computational scientists @GreenstoneBio for providing #AI #drugdiscovery. Link: nature.com/articles/s4158…

Excited to announce that MBI-MPG Conference 2025: Mechanobiology in Time and Space. Dates: 9-12 Sep 2025 Venue: Shaw Foundation Alumni House, NUS, Singapore Website: mbi.nus.edu.sg/events/mbiconf… The deadline for early bird registration is May 31, 2025 Join us!

Online Now: Pan-cancer human brain metastases atlas at single-cell resolution dlvr.it/TK6FLl

Online Now: Conserved spatial subtypes and cellular neighborhoods of cancer-associated fibroblasts revealed by single-cell spatial multi-omics dlvr.it/TJnywK

Fascinating in vivo tracking of collective cell migration under confinement @PNASNews! Reveals self-organized antiparallel streams and compressive ECM deformation. Now wondering: How do single cells navigate these complex microenvironments? 🤔 -LY www-pnas-org.libproxy1.nus.edu.sg/doi/10.1073/pn…

When you don't have new results to show in your lab meeting

📢 NIH BioArt Source, a free science and biomedical art resource library, offers an array of high-quality illustrations, vectors, & brushes, free to use & download. See the full catalog of free science and #biomedical illustrations: bioart.niaid.nih.gov #FreeResource

🚨 Paper Alert 🚨 Absolutely delighted to share our last paper on "spatial mechano-transcriptomics" in @naturemethods👇!! nature.com/articles/s4159…

Thrilled to share our new study on CAFs and NK cells, now online 🌟 in CD!! NK cells are ideal candidates for cancer killing since they don't need antigen specificity. But they are usually not active in tumors. We wondered whether this could be due to inhibition by CAFs 🧵👇