Vadim Demichev

@DemichevLab

Group Leader at @ChariteBerlin. Proteomics technologies and applications, DIA-NN author.

Berlin, Germany

Joined November 2018

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Vadim Demichev@DemichevLab · May 30

DIA-NN 2.2.0 is released! In this update we have focused on analysis speed, which is becoming increasingly critical given the rapid transition to high-throughput proteomics. The new DIA-NN 2.2.0 Enterprise achieves up to ~1.6x median speedup on 64-cores under Windows (please see…

DemichevLab's tweet image. DIA-NN 2.2.0 is released! In this update we have focused on analysis speed, which is becoming increasingly critical given the rapid transition to high-throughput proteomics. The new DIA-NN 2.2.0 Enterprise achieves up to ~1.6x median speedup on 64-cores under Windows (please see…

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Vadim Demichev@DemichevLab · Jul 25

Time and time again, it's always the same picture. DIA-NN controls FDR correctly as data reliability has been the main goal at DIA-NN's conception back in 2017 and a priority since then. Data from a very nice paper introducing the Thin-diaPASEF concept: doi.org/10.1093/dnares….

DemichevLab's tweet image. Time and time again, it's always the same picture. DIA-NN controls FDR correctly as data reliability has been the main goal at DIA-NN's conception back in 2017 and a priority since then. Data from a very nice paper introducing the Thin-diaPASEF concept: doi.org/10.1093/dnares….

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Vadim Demichev@DemichevLab · Jul 21

Assessing FDR in proteomics using full proteome recombinant libraries: pubs.acs.org/doi/full/10.10…. A very elegant work and a benchmarking dataset useful for many other things too. Protein FDR higher than precursor FDR likely due to paralogues - and this needs to be researched…

DemichevLab's tweet card. Recently, deep-learning-based in silico spectral libraries have gained increasing attention. Several data-independent acquisition (DIA) software tools have integrated this feature, known as a...

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David Gomez Varela PhD@DavidGomezVar · Jul 19

🚀 I am thrilled to share our new publication in @NatureComms By combining cutting-edge technology and computational innovation, uMetaP opens new doors for microbiome research and precision medicine. The full paper: rdcu.be/ewRZn @univienna @MetaP_Init @rapidnovor

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Vadim Demichev@DemichevLab · Jul 18

Apply today and be part of inspiring science! Deadline July 23rd! #Proteomics #Postdocs

TThierry Nordmann@NordmannThierry · Jul 1

My lab is hiring a postdoc for translational research in inflammatory skin diseases using cutting-edge proteomics Join us @MPI_Biochem. All the infos here 🔍 mpg.de/24950076/postd… Apply until July 23. Please RT.

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Yasset Perez-Riverol@ypriverol · Jul 11

🚀 Attention DIA/DDA #proteomics users! Whether you're using #DIANN, #MaxQuant, #quantms, or any tool that outputs mzIdentML and mzML, pmultiqc v0.0.29 is here!💡 Create stunning, shareable HTML reports for your collaborators in seconds.✨ Try pmultiqc.quantms.org 👇

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Evosep@EvosepBio · Jun 30

#Proteomics collaboration was never easier. Our multi-lab study showcase how standardized, automated workflows with #EvosepEno deliver consistent, high-quality results across labs and instruments. Get the full story: evosep.com/wp-content/upl…

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Vadim Demichev@DemichevLab · Jun 26

I’m thrilled to share that the main work of my PhD has been published @Cancer_Cell! With @labs_mann & @ErnstLengyel, we analyzed the progression from ovarian serous borderline tumors to invasive cancer using spatial proteo-transcriptomics and identified new therapeutic targets.

MMatthias Mann Lab@labs_mann · Jun 26

Our paper on ovarian cancer #LGSC is out in @Cancer_Cell. Using deep visual proteomics #DVP and spatial transcriptomics, we mapped how non-invasive tumors become deadly ovarian disease, and found a promising new treatment combination. cell.com/cancer-cell/fu…

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Vadim Demichev@DemichevLab · Jun 4

Mathias Wilhelm, @MartinFrejno from MSAID as well as Marie Locard-Paulet, @MagnusPalmblad and myself are organising a workshop on FDR control & trustworthiness of proteomics, hosted by Lorentz Center in Leiden, February 2-6, 2026. Stay tuned :) lorentzcenter.nl/trustworthines…

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Matthias Mann Lab@labs_mann · Jun 4

Protein digestion in 200 nL on solid-phase tips: SPEC enables low-input proteomics—even with SDS/SDC at high levels. From FFPE and muscle to high throughput plasma. SPEC is a universal and Evosep-compatible protocol. biorxiv.org/content/10.110…

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Vadim Demichev@DemichevLab · Jun 2

Happy to announce that the development version of DIA-NN has preliminary support for multi-column setups that allow acquiring multiple samples in the same run, in collaboration with @Coon_Labs. See SynchroSep-MS poster by Noah Lancaster for the concept.

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Alexey Nesvizhskii@nesvilab · May 31

The Nesvizhskii lab has 9 members attending #ASMS2025! 9 posters, contribution to 4 evening workshops, and one Bioinformatics Hub on #FragPipe. Plus multiple collaborative posters with other groups. See you in Baltimore!

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Vadim Demichev@DemichevLab · May 28

Multiplexed proteomics is getting a big boost 🚀 It's not just speed & scale ... It's also data quality, depth, rich spectra improving de novo sequencing & accurate quantification. biorxiv.org/content/10.110…

PParallel Squared Technology Institute (PTI)@ParallelSqTech · May 28

Proteomics needs to be not only specific & accurate but also faster & cheaper. To enable all of these, we introduce 9-plex PSMtags. PSMtags parallelize DIA analysis of samples & proteins. ⬛️ They also improve sequencing. biorxiv.org/content/10.110…

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Evosep@EvosepBio · May 27

Join our #ASMS Breakfast Seminar on Monday, June 2, where Ashok Dongre, Senior Director and Head of #Proteomics at @bmsnews, will share his latest research on the next generation of #Evosep chromatography workflows. Register now at evosep.com/asms2025 #teammassspec

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Selbach Lab@SelbachLab · May 27

We present SPIED-DIA – a spike-in enhanced phosphoproteomics method combining DIA with targeted sensitivity to uncover synergistic signaling in colorectal cancer cells. 👉 [rdcu.be/enPF2]()

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Varjosalo_Lab@Varjosalo_Lab · May 20

New preprint alert! We benchmarked 5 plasma enrichment methods and built an automated, cost-efficient MagNet workflow. Up to 4,200 proteins/sample identified with DIA on timsTOF Pro 2—at just a few dollars/sample. doi.org/10.1101/2025.0… @EvosepBio @bruker

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Vadim Demichev@DemichevLab · May 16

Was great to contribute to this fantastic work led by @Patrick14342109. With the new proteoform confidence module in DIA-NN, we enabled non-specific digest searches. Here's how it now works for immunopeptidomics!

PPatrick Willems@Patrick14342109 · May 16

🚨 New preprint! 🚨 Presenting diaPASEF immunopeptidomics for bacterial epitope discovery. 💥 Showcasing DIA-NN immunopeptidomics using proteome-wide predicted HLA class I libraries! 🧬 Read more: biorxiv.org/cgi/content/sh… #Immunopeptidomics #MassSpec #DIA #HLA

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Patrick Willems@Patrick14342109 · May 16

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