Wesley Wierson

...here's the beauty that is my engineered DNA repair reporter in action. This experiment brought my PhD full circle: I used the targeted knock-in approach I pioneered to engineer a stable allele that can be used for interrogation of DNA repair pathway kinetics. This idea..

e/acc isn’t a movement—it’s the recognition that stagnation is engineered and that acceleration is the only viable counterforce what Elon is doing with SpaceX isn’t about escaping Earth. it’s about creating conditions so demanding they force civilization to evolve it’s a weapon…

Now imagine a regulatory regime that would allow you to sequence -> design -> engineer -> dose an allogeneic therapy targeting multiple neoantigens (perhaps even multiple n of 1 neoantigens) in mere days.

do think discourse on engineering biology would benefit from fewer platitudes about the complexity of living systems and more informed optimism about our inevitable path to break down, understand and rebuild organisms

Scientists and founders who don’t go all in on AI will quickly be outcompeted by those who do. The dispersion will become obvious in a year. Once you see it, you realize there’s never been a better time to be a biotech builder.

You may not like it, You may not understand it, but this is what the future of biology looks like. Another successful trial completed 🐶✅ for all pet/kind.

👋We’re excited to launch DSG2-mini, our newest AI protein design model, now available in DiffuseSandbox⏳🎁, our new app for protein binder design. Click through to design a protein yourself! diffusesandbox.com 1/

Called the vet within 3 minutes of getting an email that @loyalfordogs STAY study is finally enrolling in the Twin Cities. 🐶/acc

Gray Tribe Techno-optimists Abundance Bros Let us all unite as the Technocratic Party

We don’t need to industrialize biology we need to biologize industry

Can we just get a scientific revolution yet? My latest for @PirateWires

Plasmid-based reporter assays are the bedrock of regulatory genomics. But a basic question has gone unanswered for decades: Do chromatin architectures form on plasmids transfected into mammalian cells—and does it matter? We finally have answers. biorxiv.org/content/10.110…

BIG NEWS! Ashlee Vance just profiled the first parents with not one — but two— Orchid superbabies. This is just the beginning. Every child, genetically blessed from day one.

in the 1900s, it was common to dream of the 21st century. when was the last time you heard talk of a 22nd century? it's like we don't believe we're going to make it anymore, but to endure, we MUST dream of futures worth suffering for. please, dare dream of a 22nd century.

cool video and all but is anyone actually building puppramin or do i need to pivot @LEAHLabsInc?

Update - our CIO Layla helped @LEAHLabsInc win the Audience Choice award for best pitch.

Just your friendly neighbourhood pet scientists. Oh and 🐶/acc.

Highly recommend starting a company where your Chief Inspiration Officer is on your title slide. @KisacoRes #AHNTI2025

Testing *on* animals is over. Testing *for* animals is in. man's best friend will save us. welcome to the scientific renaissance for all pet/kind 🐕

We’ve replicated this in my lab across multiple tumor antigens—with actual binding success rates so high we’re shifting effort from “can we find a binder?” to “which peptide should we drug next?" That's what protein engineering should be in 2025.