Rafa F Leiro
@rfleiro
Structural Biology & Genome Integrity @ CNIO
great work by @SusanaVazTor and team at Baker Lab 👏🏻
Thrilled to share our latest publication in Nature: nature.com/articles/s4158…. This work reflects a fantastic collaboration—special thanks to David Baker and @TimothyPJenkins. Hoping it sparks attention to this neglected health issue and drives solutions in the years ahead!
beautiful work!
Pre-print out from the @SternbergLab with our contribution on the structural side. Great effort from Matt, Egill Tanner and the rest of the team leaded by awesome Sam! A 1 year effort on my side learning helical reconstruction by cryoEM... 👇
Pre-print out from the @SternbergLab with our contribution on the structural side. Great effort from Matt, Egill Tanner and the rest of the team leaded by awesome Sam! A 1 year effort on my side learning helical reconstruction by cryoEM... 👇
1/16 New pre-print from the Sternberg Lab! We uncover how temperate phages can use RNA-guided transcription factors to remodel the flagellar composition of their bacterial host and enhance their fitness. Find the preprint and full story here: tinyurl.com/mshwjd77
If you -have years of postdoc experience, -love doing basic/clinical research, -like sharing your knowledge, -enjoy working in scientifically stimulating environment, -are looking for a permanent position Join my lab at @CNIOStopCancer! cnio.es/en/empleo/rese…
We are delighted to share our collaborative work with Ibarra Lab @3M_Lab and Fernandez-Leiro Lab @rfleiro, in which we dissect autoregulatory mechanism of Twinkle helicase! Big thank you to Sjoerd Wanrooij @Wanrooij20 and other reviewers for a smooth process! @Greg_Ciesielski ;…
I'm excited to share our new publication in @Nature! We showed that under Ni-limited conditions, similar to those in nature, #methanogens shift electron flow from [NiFe]- to [Fe]-hydrogenase Hmd with the help of a newly discovered protein complex, Elp. nature.com/articles/s4158…
Excited to share our latest paper, published in Nature Communications! As first author from @3M_Lab, I’m proud of this collaborative effort with @LabMito and @rfleiro, where we dissect the autoregulatory mechanism of the mitochondrial helicase Twinkle. 🔗 nature.com/articles/s4146…
Congrats to MCB's Eva Nogales on her election to the Fellowship of the Royal Society! 👏🎉 @royalsociety @NogalesLab royalsociety.org/news/2025/05/n…
Great tool for AUTOMATIC primer design for cloning using in vivo DNA assembly! awesome work with the group of Sebastian Hiller and Radu Leonte spearheading! Upload your plasmid map, click on what you want to do and download your primers and new map!academic.oup.com/nar/advance-ar…
In the second part of session 5 Meindert Lamers from @LUMC_Leiden will talk about how to target bacterial DNA polymerases for the next generation of antibiotics. Registration for #CFM_MolMech still open at bit.ly/42hyRh0
The fifth session will deal with the mitochondrial DNA replication machinery and the RAD51 modulators, bring some surprises about large transcriptional cofactors and show how to visualise an eukariotic origin of replication. @zhang_imperial @CostaLabCrick @rfleiro @NogalesLab
🔊Last days to send your abstract for #CFM_MolMech! 🔴Deadline: April 24, 2025🔴 📅The meeting will take place May 28th - 30th at #CNIOStopCancer 🏃Read about the 5th and 5th I sessions on the 🧵👇 With the support of @CaixaResearch 🔗More info: bit.ly/42hyRh0
This is going to be an amazing meeting, great opportunity to show your latest research. We will select quite a few talks from abstracts, don't forget to submit yours!
🔴⚠Next CNIO-@CaixaResearch Frontiers Meetings: Machines acting on DNA and RNA, a molecular mechanistic perspective. 📆May 28-30th 👥Organizers: @LlorcaLab, @rfleiro and @NogalesLab. 🔗More info and registrations: cnio.es/eventos/machin…
We have 2 PhD Positions🔥Join us in Madrid!!
The UNION consortium is excited to announce 17 open #PhD positions! UNION aims to address the challenges of our ageing society. It involves experts from various disciplines (PIs tagged below) and uses cutting-edge technologies. Contact the individual PIs with your EOI
🔎#CFM_MolMech: a meeting exploring the integration of structural, biochemical, and biophysical insights into cryo-EM advances that reveal molecular machines behind DNA/RNA processes. 👥 Meet the organisers: @LlorcaLab, @rfleiro and @NogalesLab. cnio.es/eventos/machin…
🔴⚠Next CNIO-@CaixaResearch Frontiers Meetings: Machines acting on DNA and RNA, a molecular mechanistic perspective. 📆May 28-30th 👥Organizers: @LlorcaLab, @rfleiro and @NogalesLab. 🔗More info and registrations: cnio.es/eventos/machin…
One more day left to apply! Come join us in our effort to turn chemotherapy into a precision medicine.
We are hiring! Opportunity for a project manager to oversee all aspects of a multi-centre clinical research project to implement an AI-based genomic test that predicts resistance to chemotherapy - Madrid, Spain. PM for more details. Deadline 25 January! cnio.es/en/empleo/resa…
Contrato postdoctoral! Si estás interesado en estudiar la inestabilidad genética asociada a la replicación en la levadura Saccharomyces cerevisiae, tenemos disponible un contrato postdoctoral en nuestro laboratorio por tres años. Contacta a través de [email protected]
La inteligencia artificial crea por primera vez un tratamiento para una enfermedad olvidada por las farmacéuticas. Los investigadores, con el nobel David Baker y @SusanaVazTor a la cabeza, hablan de “democratizar” el descubrimiento de medicamentos: elpais.com/ciencia/2025-0…
El nuevo grupo de Gonçalo Bernardes en el #CNIOStopCancer busca desarrollar los próximos fármacos de precisión contra el cáncer.🎯💊 cnio.es/noticias/el-nu…