vaccine_clint
@ClintVaccine
Ph.D. Student in Ivelin Georgiev's lab at the Vanderbilt Vaccine Center
Using #antibody sequence alone, can we predict whether two antibodies target overlapping epitopes? A new suite of algorithms developed by @ClintVaccine: Contrastive Learning Enables Epitope Overlap Predictions for Targeted Antibody Discovery biorxiv.org/content/10.110…
An ambitious project led by @VUMChealth investigators aims to use #AI technologies to generate antibody therapies against any antigen target of interest. @IG_lab will serve as the project principal investigator. news.vumc.org/2025/03/10/vum…
Happy to be part of a disruptive project out of my lab. Essentially #ChatGPTForAntibodies — feed in an antigen sequence and it returns an antibody sequence that has a high probability of binding.
Monoclonal antibodies are crucial in medicine and research, but their discovery is slow, costly, and complex. What if #AI could change this - creating fully human #antibodies, on demand, for a target of interest? The magic is in #MAGE: biorxiv.org/content/10.110…
Online now! Discovery and characterization of a pan-betacoronavirus S2-binding antibody dlvr.it/TDgKMN
Our group has multiple #postdoc openings in the area of #antibody discovery and #vaccine design, both for experimental and computational scientists. Please reach out if interested.
Not sure it is a good time for this....H5N1
"Cow cuddling" is a recent trend to reduce stress and loneliness — but cattle may prefer women over men. newscientist.com/article/243242…
Watching this closely: Transmission of Highly Pathogenic Avian Influenza between mammals is concerning. "...the virus may be transmitted from cow-to-cow, in addition to previous reports indicating cattle were acquiring the virus from infected birds." tinyurl.com/4dz2zvbm
I'm excited my friend Alex's work has been published and that I was able to take part! Another example of LIBRA-seq identifying ultra-potent antibodies while only requiring a handful to be tested in the lab.
A public VH-based class of ultra-potent hPIV3-neutralizing #antibodies. Work led by soon-to-be Dr. Alexandra Abu-Shmais from our group, in collab with the labs of @jjmousa, @RHCarnahan, @croweje. journals.aai.org/jimmunol/artic…
A protective pan-betacoronavirus #antibody that also recognizes zoonotic alpha- and delta- #coronaviruses. Multi-year effort led by Nicole Johnson, Steven Wall, Kevin Kramer, @ClintVaccine, in collab with @McLellan_Lab, Giuseppe Sautto, and many others. biorxiv.org/content/10.110…
This paper, led by Ph.D. candidate Matt Vukovich, is now published in @ASMicrobiology Journal of Virology: journals.asm.org/doi/10.1128/jv…
It is hard enough to design #HIV #vaccines that elicit neutralizing #antibody responses that show some breadth of reactivity in animal models, but trying to deconvolute these responses at the single-cell level is yet another challenge. biorxiv.org/content/10.110…
A collaborative effort led by PhD candidate Steven Wall shows that #antibodies from children exhibit broad #SARSCoV2 neutralization, including against highly resistant #virus variants, but have similar sequence features compared to adults: @CellRepMed cell.com/cell-reports-m…
Great work by Matt @MatthewVukovic investigating what the monoclonal antibody response looks like when you optimize an HIV vaccine for strain breadth, bnAb sensitivity, and minimizing shared glycan holes
Development of LIBRA-seq for the Guinea Pig Model System as a Tool for the Evaluation of Antibody Responses to Multivalent HIV-1 Vaccines biorxiv.org/cgi/content/sh… #biorxiv_immuno
News: NIH clinical trial of universal flu vaccine candidate begins dlvr.it/Sw8vSD