Alex Chudnovskiy 🇺🇦
@ChudnovskiyLab
Pathology-oriented multiplexing enables integrative disease mapping nature.com/articles/s4158… PathoPlex is a highly multiplexed imaging at subcellular resolution with a software package (spatiomic) to interpret protein co-expression patterns (clusters) across biological layers.
Cell-intrinsic CD4 T cell tolerance: a new frontier in therapy? dlvr.it/TM4ncq #immunology
GATA2 Induces a Stem Cell-Like Transcriptional Program in Macrophages that Promotes Atherogenesis. biorxiv.org/content/10.110… #biorxiv_immuno
So interesting!
Why do some genetic mutations devastate specific tissues while sparing others? We explore this question in GGC repeat disorders, revealing a mechanism linking protein aggregation to tRNA splicing failure in the brain. 🧵 on our new paper in Science: 🔗 science.org/doi/10.1126/sc…
Clonal driver neoantigen loss under EGFR TKI and immune selection pressures | Nature nature.com/articles/s4158…
Structure of gut microbial glycolipid modulates host inflammatory response: Cell cell.com/cell/fulltext/…
#aging #immune_aging NEW PREPRINT FROM Artyomov&Randolph labs: How mouse age-associated GZMK+ CD8 Taa cells develop and what are correct surface markers for them biorxiv.org/content/10.110… Among other things we - Using OT1-Rag2ko mice explicitly show the TCR dependence and yet…
🎯 Drs. Xian Li, Wenhao Chen, and Dawei Zou at @MethodistHosp show that targeting stem-like CD4+ T cells offers great therapeutic potential: disrupting their persistence could mitigate #autoimmune pathology and transplant rejection! 🔗 go.nature.com/4kU4PYj
Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement: Cell cell.com/cell/fulltext/…
Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia: Cell cell.com/cell/fulltext/…
TGF-β and IL-12 conversely orchestrate formation of CD103+ CD8 tumor-resident memory T cells to regulate response to therapeutic cancer vaccine cell.com/iscience/fullt…
I am thrilled to share with the world a new preprint, spearheaded by the truly amazing Jose Reyes in partnership with @LoweLabMSKCC. Focused on the benign to malignant transition in PDAC, uncovering roles of plasticity, tissue remodeling and P53 -> biorxiv.org/content/10.110…
Integrin CD103 reveals a distinct developmental pathway of autoreactive thymocytes in TCR transgenic mice @NatureComms nature.com/articles/s4146…
Gestational changes in Hofbauer cells alter their interactions with Listeria monocytogenes @SciImmunology science.org/doi/10.1126/sc…
Check out a new Review article on clonal hematopoiesis by Jen Trowbridge and collaborators @NatureCancer doi.org/10.1038/s43018…
Mitochondrial origins of the pressure to sleep | Nature nature.com/articles/s4158…
Induction of a mismatch repair deficient genotype by tailored chemical mutagenesis in experimental models of cancer dlvr.it/TM0DWX
🛡️ Drs. @_AmandaChen, Kah Min Yap, Imran House, Phillip Darcy, and @PaulBeavis4 developed #CRISPR-edited armored CAR T cells that deliver cytokines directly to tumor sites. @Nature article: go.nature.com/3I8Nk8S Discussion: bit.ly/3Gu9UIF
I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13) nature.com/articles/s4158…
Proud to share @niseto’s (new PI @TheCrick) paper: As a postdoc (@CSHL/@HopkinsMedicine), he found #NETs in necrotic tumors—I shrugged. But he looked closer: NETs block tumor vessel perfusion, causing necrosis, hypoxia, EMT & #Metastasis. nature.com/articles/s4158… @JHU_BDP @Nature