Immune Regulation News

🩺 This review analyzes recent findings regarding the role of #Treg cells in colon cancer progression by evaluating preclinical and clinical studies that explore immune cell composition, function, and modulation within the tumor microenvironment. 👓 bit.ly/4m9Z1L3

🧫 Researchers engineered a bispecific #antibody, FRP303, targeting 4-1BB and CCR8, which are co-expressed on a highly immunosuppressive subset of tumor-infiltrating regulatory T cells. 👉 @iScience_CP | bit.ly/4lNUmyI

🦴 Researchers with Hua Jiang at @MedUnivSC show that ST2+ Treg cells are enriched in bone marrow of humans and mice with AML and promote CD8+ T cells depletion and exhaustion. 🔓 @NatureComms | go.nature.com/46UUAiP

💩 Researchers showed that a new strain of the bacterial genus Hominenteromicrobium isolated from the feces of patients who responded to programmed cell death 1 blockade augmented #antitumour responses in mice. @Nature | go.nature.com/46oJCSG

🎯 Drs. Xian Li, Wenhao Chen, and Dawei Zou at @MethodistHosp show that targeting stem-like CD4+ T cells offers great therapeutic potential: disrupting their persistence could mitigate #autoimmune pathology and transplant rejection! 🔗 go.nature.com/4kU4PYj

🐁 Scientists at @Tongji_Uni showed that mice with systemic, Kupffer cell–specific, or myeloid cell–specific Mas1 deficiency were vulnerable to liver ischemia-reperfusion injury. 👉 @ScienceTM | bit.ly/4m3KPDu

💓 Dr. Ying-Jie Wang and scientists at @UniofOxford reported that postmortem and explanted human hypertrophic #cardiomyopathy hearts exhibited chronic focal leukocyte infiltration and prominent activation of immune cells. @ScienceTM | bit.ly/40X2ynP

💡 Jing Xuan Lim and researchers at @UniofNewcastle demonstrate that PD-1 deficiency enhances the function of #Treg cells through expression of a compensatory network of coinhibitory receptors. 🔓 @NatImmunol | go.nature.com/4kNYNbB

Drs. Daolin Tang, Ruochan Chen, and co-authors explore the therapeutic potential of targeting pattern recognition receptors in treating infectious, inflammatory, #autoimmune, and malignant diseases. | @sigtrans_sttt 📚 Read the review: go.nature.com/46JeAVs

⌛ Tick tock, one week on the clock! Subscribe to one of our 20 immunology or cell biology newsletters before July 18 for a chance to win a personalized lab coat. bit.ly/3YYyzuM

New in @GenomeBiology! A team at Sun Yat-sen University performed a meta-#GWAS and identified susceptibility genes for nasopharyngeal #carcinoma. bit.ly/4lmnE7e

Register now for On Demand Access to @KeystoneSymp #NeuroImmune Interactions : A Systems Wide Perspective, this June to explore emerging research! hubs.la/Q02-rZFh0 #KSNeuroImmune25

📢 @ValentinaVenzin, @CristianBecc, and a team in the @iannaconelab showed that CD4⁺ T cells can license #Kupffer cells to rescue dysfunctional CD8⁺ T cells in the liver. go.nature.com/3Ggjajr

New in @NatImmunol! The @DrRGJonesLab at the @VAInstitute identified the prostaglandin I2 (prostacyclin) receptor PTGIR as a cell-intrinsic regulator of #Tcell exhaustion. go.nature.com/4lcyE7i

🔎 Scientists at @BIDMChealth investigated how CD39-AS affects the function of #Tregs and Th17 cells in healthy subjects and inflammatory bowel disease patients. 🔗 go.nature.com/3HeW3WD

🧪 Dr. Giulia Marelli and researchers conducted an unbiased genome-wide CRISPR screen of primary macrophages, confirming the function of known regulators in TAM responses and revealing new insights into the behavior of these cells. 📖 @NatImmunol | go.nature.com/4kkKVFg

💡 Although LAG-3 is known to bind to major histocompatibility complex class II, Dr. Jasper Du and scientists at @nyugrossman demonstrate that MHC class II interaction alone is insufficient for optimal LAG-3 function. @CellCellPress | bit.ly/45SIl66

💉 Investigators described an association between mechanosensation and cross-presentation by cDC2A cells, contributing to the continued development of dendritic cell vaccines. 🔓 @jitcancer | bit.ly/45DyeBW

📊 Researchers at @UofMaryland found that CD8+ T cells promote homing of CD4+Foxp3+ T regulatory cells to the tumor bed by increasing levels of CCR5 chemokines in the tumor microenvironment in an IFN-γ and TNF-α dependent manner. 🔗 bit.ly/4lxrlqF

💡 Researchers provided insights into the critical role of #mitochondrial 1-carbon metabolism and MTHFD2 in governing the differentiation of CD34-lineage cells into Tfh cells. @CircAHA | bit.ly/4et8sCW