Christian Cao
@ChristianCao11
@uoft MD ‘26 | @ucalgary alum | Automating evidence synthesis @theottolabs
Today we’re announcing otto-SR, an AI workflow to perform systematic reviews 3000x faster By using gpt-4.1 and o3-mini, ottoSR beats humans at all tasks In two days, we conducted 12 work-years of Cochrane research–finding 2x more relevant papers and altering key conclusions 🧵
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👀Using an autonomous agent based on o3-mini and GPT-4.1, a team from Harvard, MIT & other institutions reproduced and updated an entire issue of Cochrane Reviews in two days… saving 12 person-years of work! The AI reviews captured more papers & were more accurate than humans.
Honored to be featured in @statnews! Systematic reviews inform medical guidelines, but are slow and error-prone (even sometimes including retracted studies!). We're building AI-powered living reviews to fix this — a new paradigm for evidence synthesis
A new study found some systematic reviews included retracted studies from paper mills, journals that produce low quality research trib.al/oi86GYy
#TemertyMed and @UCalgary researchers develop innovative approach using AI to streamline the screening process for systematic reviews. bit.ly/3QKUTn2
We created & validated text prompts for LLM screening in systematic reviews. High performing. Could filter out 65-95% prior to human review or replace 1 human. Reduces cost. @ChristianCao11= superstar @UofT @UCalgary @ucalgarychi @cochranecollab #LLM #AI acpjournals.org/doi/10.7326/AN…