Piel Lab
@piel_lab
Exploring & engineering bacterial #naturalproducts at @ETH Zurich Institute of @Microbio_ETH | Therapeutic lipopeptides by @AnnaVagstad | Run by lab members
Out now in @Chem_CP , we collaborate with @piel_lab to discover a prenyltransferase+terpene cyclase fusion enzyme that modifies Trp residues in RiPPs to yield complex steroid-like scaffolds! Congrats to @HubrichFlorian, @sanathrajkk0 for leading this!🎉authors.elsevier.com/c/1jjdi8jWHELG…
Congrats to @HubrichFlorian & @sanathrajkk0 for this exciting story finally being published. Thanks for the fruitful collaboration with @chekanlab. If you are interested in the chemical space of #RiPP #biosynthetic #enyzmes and #isoprenoids, click here: sciencedirect.com/science/articl…
We are super proud of @MrMunsterberg for winning the #DiscoveryAward2024 at the #ICNPR2024 last week! Very well deserved, Johannes. Keep following us to stay tuned for updates on his amazing research!
We are having a great time being @ETH_DBIOL symposium in #Davos again. Listening to fantastic talks, discussing science on posters and of course socializing with peers.
Thank you @ScienceMagazine for highlighting our paper here!
New in Science: Approaches used in two independent studies are an important step forward for rational engineering of large enzyme complexes for small-molecule drug discovery and production. Learn more ⬇️ 📄: scim.ag/6qs 📄: scim.ag/6qr
Congrats to @AnnaVagstad bringing this amazing story to the finish line! Thank you to everyone involved from @BroderickLabFeS for the fantastic collaboration! If you are interested in the enzymatic mechanism of peptide epimerization by rSAM, make sure to read it.👇
📷 Detection of the α-Carbon Radical Intermediate Formed by OspD: Mechanistic Insights into Radical S-Adenosyl-l-methionine Peptide Epimerization |Journal of the American Chemical Society @montanastate #Radical #Detection #OspD #SAM #Peptide #Epimerization pubs.acs.org/doi/10.1021/ja…
We are very proud of @Mathijsfjm for starting his own research group and even more exciting to see what amazing research will come from his lab! Stay tuned for exciting projects 👨🔬🧫⚗️
📷 Detection of the α-Carbon Radical Intermediate Formed by OspD: Mechanistic Insights into Radical S-Adenosyl-l-methionine Peptide Epimerization |Journal of the American Chemical Society @montanastate #Radical #Detection #OspD #SAM #Peptide #Epimerization pubs.acs.org/doi/10.1021/ja…
We are very proud of @aefraley for being one of these professor! Stay tuned for amazing research coming from her lab👩🏫👩🔬🧫⚗️
On the proposal of ETH Zurich President @Joel_Mesot , the ETH Board appointed 12 professors and awarded the title "Professor of Practice" once. 👨🏫👩🏫 brnw.ch/21wF6YH @MortezaAramesh @ellliottt
Exciting news! Did Acidobacteria also pop-up in your MAGs? In our new paper we identify sponge-type polyketides from this unusual phylum: sciencedirect.com/science/articl… Have a read for more details. We are excited to see where else we can find Acidos!
Winter wonderland has started in Switzerland! Snowy greetings from the Pielis ❄️☃️
Congrats to @HubrichFlorian for his amazing talk on RiPP modifying enzymes! #VAAMNP @Helmholtz_HIPS
