Catherine Phelps
@CatMPhelps
http://CatMPhelps.bsky.social PhD Candidate in the @MeiselLab at University of Pittsburgh @Pitt_PMI 🏃♀️🛼👩🔬 https://authors.elsevier.com/c/1lPCrL7PXuFJv
I am BEYOND excited to share my PhD thesis research is officially published in @CellCellPress today. Read on for an exciting story about how #exercise promotes antitumor #immunity by modulating behavior of the #microbiome 🏃♀️🦠 authors.elsevier.com/c/1lPCrL7PXuFJv
AAI Members in the News! For her graduate thesis with Dr. Marlies Meisel at @Pitt_Medicine, @CatMPhelps found that #exercise improved #cancer outcomes and enhanced responses to #immunotherapy in mice by reshaping the gut #microbiome. Congrats! 🔗 ow.ly/RIMj50WnXoy
Online now: Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity dlvr.it/TM3NYq
Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity @ImmunityCP @surya25_pandey @YinanGong @RH_Laboratory cell.com/immunity/fullt…
A potent bacterium in the human gut can supercharge the effects of some cancer drugs go.nature.com/4lDfxU8
#MicrobiotaPower & #Exercise! Phelps, Meisel &co show @CellCellPress that exercise drives formate from microbiota that in turns activates NRF2 in CD8 T cells driving STAT1/IRF8 programs that potentiate immune checkpoint inhibitor efficacy against melanoma dlvr.it/TLqLW7
Exercise induced #microbiome changes fight #cancer ! @CatMPhelps what an incredible paper.... @SabinehazanMD looks like another support for your original ideas in this space ! cell.com/cell/abstract/…
🏃♂️💥 Exercise boosts immunotherapy! New study shows exercise increases gut microbiota-derived formate, enhancing CD8+ T cell–mediated antitumor immunity via Nrf2. ⭐️Formate may be a new biomarker for better ICI response in melanoma. @CellPressNews @OncoAlert #microbiome #cancer…
#ScienceSaturday 🏃♂️🧬 Can exercise really help fight #cancer? 📢 A new study in @CellCellPress shows exercise rewires the gut #microbiome to enhance immune responses against tumors. ➡️ @CatMPhelps et al. found exercise increases levels of a microbiota-derived metabolite called…
True academic friendship is agreeing to sit in the audience for their 8:15am presentation
Exercise helps the immune system to fight tumours by stimulating microbes in the gut to make a compound known as formate go.nature.com/44jPqvg
New University of Pittsburgh research shows gut bacteria are responsible for how exercise boosts cancer treatment in mice, pointing to possible future therapies for humans. explorevenango.com/state-news/202…
Nice thread showing highlights of our study:
Why is exercise anti-cancer? Mice that exercise suppress tumors better than those that don't If those mice are treated with antibiotics, the gut microbiome is depleted and the effect is pretty much gone: it's (at least partly) mediated by gut bacteria 🧵
🔥HOT 2025 DISCOVERY! Original post @EricTopol CELL.com July 2025 💪Exercise could SAVE lives by supercharging melanoma immunotherapy via gut microbiome! 🪂Dive into our MUST-SEE Exclusive Video Link: oncologytube.com/2025-melanoma-… #MelanomaHope #ExerciseRevolution…
New University of Pittsburgh research shows gut bacteria are responsible for how exercise boosts cancer treatment in mice, pointing to possible future therapies for humans. exploreclarion.com/state-news/202…
Early-life exercise extends healthspan but not lifespan in mice | Nature Communications nature.com/articles/s4146…
Thank you for the write up of our study! @Nature
Exercise helps the immune system to fight tumours by stimulating microbes in the gut to make a compound known as formate go.nature.com/44jPqvg
How exercise works through the gut microbiome to enhance response to cancer immunotherapy cell.com/cell/fulltext/… @CellCellPress
Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression @CellCellPress @CatMPhelps @MeiselLab cell.com/cell/fulltext/…
Great brief study summary from @Nature ! Workouts can help gut microbes to quell cancer nature.com/articles/d4158…
