Jon Brestoff
@BrestoffLab
Associate Professor MD/PhD @WashuMedicine studying #immunometabolism and #mitochondria transfer in metabolic diseases like #obesity #diabetes and #LeighSyndrome
Curious about #mitochondria transfer? Check out our latest #MitoTransfer review with the @theHumanBorch in @Nature Feel free to post your thoughts, ideas, and questions below. Please RT to help grow this blossoming field. nature.com/articles/s4158…
Gemma Conroy @Nature wrote a fantastic news feature on #mitochondria transfer. It’s exciting to see so much interest! Many good friends and colleagues highlighted here! Check it out. nature.com/articles/d4158…
New organelle found in the Human body. The organelle, which is a form of specialized structure, has been given the name “hemifusome” and may help researchers develop new treatments for disease. nature.com/articles/s4146…
science.org/content/articl… Neurons transfer mitochondria to cancer cells in a process that promotes metastasis. #MitoTRACER in @Nature by @GreletLab
Thank you to the @cure_mito Foundation for making a major gift to my lab @washu_pathology @washumedicine in support of our research on Leigh Syndrome. We will use these incredible resources to advance a new mitochondrial therapy that my lab developed for this fatal disease.
Many thanks to @Cell_Metabolism for featuring part of my journey in their 20th Anniversary Voices series. It's humbling to share page space with scientists who’ve inspired me along the way. @washumedicine @washu_pathology #5: "Mitochondria on the Move" cell.com/cell-metabolis…
This is one of the most mysterious findings about mitochondria.
Discussion with Gordon Freedman @mitoworld_org on how discovering mitochondria cristae alignment led to ideas around the social lives of mitochondria mitoworld.org/mitochondria-a…
Tissue source for #mitochondria #transplantation affects the therapeutic benefit against #obesity and #metabolic #syndrome. link.springer.com/article/10.100… Makes sense given that mitochondria in various tissues and cell types can be massively different.
It was wonderful to celebrate my greatest mentor, Steve Teitelbaum, and his remarkable career today. He touched the lives of many. In my case, he gave me the opportunity to pursue my wildest ideas. Thank you Steve!
Mitochondria on the ALL IN podcast @theallinpod Thank you @friedberg for educating us about mitochondria. Covering our MitoBrainMap paper and @BrestoffLab's work on mitochondria transfer. @Jason @chamath @DavidSacks youtube.com/watch?v=rCrb4T…
This is amazing!
A map of mitochondrial biology reveals the energy landscape of the human brain Wonderful and fun collaboration with @MichelTdS and many others! @AnnaMonzel @OrianShirihai Ayelet Rosenberg was the courageous one who tackled this project, and Eugene Mosharov was the engine…
Abstract submission deadline for 2025 #Mitochondrial #Medicine @UMDF is March 31 umdf.smapply.org/prog/2025poste… SciMed Scholarships and talks available from abstracts June 18-21, 2025 in St Louis by the Arch One of the most inspiring conferences I have been to! Please RT
“Shunt-ing” down obesity with novel endogenous metabolites dlvr.it/TJTTtH
A study in @NatureComms shows that Zika virus NS1 induces tunneling nanotubes in placental cells, which facilitate viral spread and transport of mitochondria in placental cells. go.nature.com/41iQooH
Metabolic and stress response adaptations in T cells to fever and physiological heat dlvr.it/TJ5fwj #immunology
Breakthrough in mitochondrial medicine! Our MOT™ technology delivers healthy #mitochondria to damaged cells, tackling neurodegenerative diseases at the source. Now patented in Japan & the U.S., we're driving the future of regenerative therapies. #ALS Learn more:…
Bidirectional #mitochondria transfer swaps T cell mitochondria with those from cancer cells to impair anti-tumor immunity. Check out my News & Views in @Nature summarizing this incredible paper by Ikeda et al. Nature 2025 nature.com/articles/d4158…
