Guido Barzaghi
@BarzaghiGuido
NYU postdoc with Tsirigos and Aifantis labs. Former EMBL Heidelberg PhD with Krebs and Zaugg labs.
Having a stressful day? Lay back, crack a beer open and read about how chromatin accessibility responds to TF binding perturbations at the single molecule level bit.ly/3XQMFxN. I'm so grateful to my PhD mentors Arnaud Krebs and @zauggj for these super productive years!!
#AifantisLab version 2025. So lucky to work with this talented group of scientists! Huge thanks to @nyugrossman and @NYUGSOM_Path for supporting our team...! #Science #Cancer #NYC
Excited to share the latest story from the @arnaud_kr lab @embl ! Together with @ChristineMoene we used Single Molecule Footprinting to reveal that RNA Pol II occupancy occurs at surprisingly low-frequency at mammalian promoters! Thread below (⬇️) 1/11
What a home run! Congratulations @IevaRau @AMathelier and others 🙌 Very thankful to have been involved!
🎉 Excited to share the peer-reviewed version of our manuscript describing COBIND, a tool for revealing TF co-binding patterns using non-negative matrix factorization. Great work led by @IevaRau @NCMMnews @NordicEMBL @UniOslo_MED @UniOslo academic.oup.com/nar/advance-ar… @NAR_Open
Swing by for a taste of TFs, chromatin and single molecule footprinting!
Join us this Wednesday for our next Fragile Nucleosome seminar, with talks from Guido Barzaghi (@BarzaghiGuido) and Roman Sarott (@RomanSarott) & Sai Gourisankar (@saigourisankar)! Register here: osu.zoom.us/webinar/regist…
Nature restoration law: MEPs have adopted their position for negotiations with Council. The EU must have restoration measures in place by 2030 covering at least 20% of its land and sea areas, say MEPs.
Fantastic to see the binding specificity of TFIIIC structurally resolved...and even more so to see how sometimes the hard work of a PhD pays off so beautifully. Way to go @WolframSeifertD!!!
We (@MathiasGirbig, Muellerlab @EMBL) are thrilled to share our peer-reviewed publication of the human TFIIIC in SciAdv: science.org/doi/10.1126/sc…. Do you want to see the structure of the last general transcription factor standing without the complete 3D structure? Tweetorial 👇
Such a brilliant step forward towards the study of TF co-binding. I'm very glad to have been involved in the validation of COBIND by Single Molecule Footprinting
We're excited to share our manuscript describing COBIND, a novel tool for the identification of transcription factor co-binding patterns with non-negative matrix factorization biorxiv.org/content/10.110… 1/9
Deciphering the multi-scale, quantitative cis-regulatory code | Review | Molecular Cell cell.com/molecular-cell…
So many friends & many people I don't even know their names helped us since the nature-acted, man-made #earthquaketurkey. THANK YOU for being there. For current situation in the village, please check this link and share this with your friends gofund.me/ae11ecc6
What a titanic work! Well deserved @ElisaKre 👏👏👏
Happy to announce that our story on #DNAmethylation at #enhancers is out today in @MolecularCell! tinyurl.com/smc5yccy It was a fantastic PhD journey in the lab of @arnaud_kr @EMBL. Follow the 🧵 to find out whether #DNAmethylation is important for enhancer activity: (1/9)
Very happy that my Ph.D work is out in @CellReports. What a nice gift to start 2023! Thanks again to all the people who contributed @DaanNoordermeer, @s3bastien75, @CelHern, @GilardiPascale, @PFNGS_I2BC and all the other ones not on twitter cell.com/cell-reports/f…
The Green Algorithms project has a brand new website! It regroups (or will soon) the different tools we built, some tutorials, and more resources around green computing 🌱 Same place: green-algorithms.org The online calculator has just been moved to calculator.green-algorithms.org
New video up: simple advice for doing a bioinformatics PhD youtu.be/GWCuAQVa0DU
📢Preprint drop! -Are chromatin modifications a cause or consequence of transcription? (or both) How do DNA motifs affect the function of marks? Can combinatorial modifications synergise? We present our epigenome editing study, & unexpected findings👇+🧵 biorxiv.org/content/10.110…
Love this whole article profiling multiple labs run by two PIs! Happy to be leading this wave of the future with Shantanu! @shantanuXsingh @broadinstitute asbmb.org/asbmb-today/pe…
Come check how we perturb Transcription Factor Cooperative Binding across the mammalian genome at poster 7️⃣0️⃣ #EMBLTranscript