Zeynep Baharoglu
@BaharogluZeynep
Scientist - Group leader at Institut Pasteur Paris - Bacterial stress responses, sub-MIC antibiotics, AMR, RNA modifications
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find me there => @zeynepbaharoglu.bsky.social 🦠💫 I'll continue posting about bacteria, stress, RNAs, antibiotics, ...
Transfer RNA (tRNA) anticodon variants found in human genomes cause errors in protein synthesis, including mis-incorporation of alanine in proteins at threonine, glutamate, glycine, or valine codons. bit.ly/4lmF4QN
Investigation of the global translational response to oxidative stress in the model archaeon Haloferax volcanii reveals untranslated small RNAs with ribosome occupancy biorxiv.org/content/10.110…
Really cool link between tRNA cpy number and bacterial cell wall 🦠 academic.oup.com/nar/article/53…
Post-Transcriptional Regulation of the MiaA Prenyl Transferase by CsrA and the Small RNA CsrB in Escherichia coli pubmed.ncbi.nlm.nih.gov/40649849/
Discovery of First-in-Class Inhibitors Targeting a Pathogen-Associated Aminoglycoside-Resistance 16S rRNA Methyltransferase 🦠 NpmA pubmed.ncbi.nlm.nih.gov/40643688/
Mutations in fusA lead to drug bound ribosome inactivation and prevent error cluster fomation upon aminoglycoside treatment, limiting proteotoxic stress and further aminoglycoside uptake. biorxiv.org/content/10.110…
Modifications of microbiome-derived cell-free RNA in plasma discriminates colorectal cancer samples nature.com/articles/s4158…
This week we publish in @NatureBiotech "High-precision cytosine base editors by evolving nucleic-acid-recognition hotspots in deaminase". In this work, we show that both nucleotide and context specificity of deaminases can be reprogrammed by hotspot-focused directed evolution 1/n
The eukaryotic tRNA chaperone La impacts tRNA modification levels (queuosine and others). Interesting because in procaryotes, tRNA modif enzymes themselves are thought to be chaperones. In both cases, there seems to be a link between modif and chaperones. academic.oup.com/nar/article/53…
A-to-I mRNA editing in bacteria can affect protein sequence, disulfide bond formation, and function academic.oup.com/nar/article/53…
Loss of s2U tRNA modification induces antibiotic tolerance in Yersinia pseudotuberculosis biorxiv.org/content/10.110…
Post-transcriptional Modifications of the Large Ribosome Subunit Assembly Intermediates in E. coli Expressing Helicase-Inactive DbpA Variant. 🦠On time points at which m1G, m2G, m7G, and D are incorporated into rRNA in E. coli biorxiv.org/content/10.110…
Extended Shine-Dalgarno motifs govern translation initiation in Staphylococcus aureus biorxiv.org/content/10.110…
Very cool : synthetic FAD analogues are synthesized and used by bacteria and can influence antibiotic response 🦠💫 Escherichia coli FAD synthetase for the biosynthesis of FAD nucleotide analogues results in aminoglycoside antibiotic tolerance biorxiv.org/content/10.110…
Detection of stress-dependent m5C rRNA dynamics in E. coli using m5C-Rol-LAMP: qPCR-based method to quantify site-specific m5C in total bacterial RNA =>stress (heat, stressox) dependent changes in rRNA, from Kirsten Jung lab 🦠 #RNAmodifications biorxiv.org/content/10.110…
RNase L cleaves most tRNAs in the anticodon loops into various tRNA-derived RNAs (tDRs) including 5'-tDRAla that shows a translation inhibitory effect. Some tRNAs are also cleaved in variable loops. bit.ly/3YTwlNq
Organoid model showing a role for tRNA modifications and codon usage in Shigella infection 🦠💫 nature.com/articles/s4158…
Our May 2025 Newsletter featuring @BaharogluZeynep @zeynepbaharoglu.bsky.social Dr. Zeynep Baharoglu is Research Director at the CNRS Institut de Biologie Physico-Chimique and the Institut Pasteur in Paris. Subscribe to our newsletter to learn more about the experts.
Hosting oppotunity in my lab MSCA Post-doctoral Fellowship at IBPC Paris on RNA modifications in bacteria (FRANCE) 🦠💫 RT euraxess.ec.europa.eu/jobs/hosting/m…