RNA

This work developed a structure model for the lncRNA SChLAP1, identified protein binding regions, and uncovered an unexpected role for retroviral insertions in forming an RNA conformational landscape. bit.ly/440bLhb

Genetic changes in an RNA-editing enzyme reduce editing of a brain receptor gene, leading to abnormal receptor function, neuronal overactivity, etc. bit.ly/3TGUN1i #RNAediting #Neurodevelopment @CEITEC_Brno @MasarykUni @MUNI_Science @Qiupei638080 @cheriyanna

New paper by Kwok Lab @kitkwok6. RNA G-quadruplex structure targeting and imaging: recent advances and future directions. bit.ly/45C3AJf

This review outlines how the ring-shaped RNA helicase Rho regulates bacterial gene expression, both genome-wide and at specific loci, using constitutive or alternative condition-dependent mechanisms. bit.ly/4l22ICy

Human CCR4 deadenylase homolog Angel1 along with endonuclease N4BP2 and the SKI-exosome complex promotes degradation of aberrant mRNAs that lack stop codons causing ribosome stalling at the poly(A)-tail. bit.ly/4lsYWC6

Mature sperm contain small RNAs, which are implicated in transmitting extra-chromosomal information from fathers to offspring. How many specific small RNAs are required for impact remains unclear. bit.ly/44zI1I4

A bioinformatics approach and wet lab validations identify tissue-specific SEC31A alternative splicing mediated by RBM47 that facilitates lipid transport. bit.ly/4nr2YN5

Kraus et al. report absolute miRNA concentrations required for productive cleavage of highly expressed transcripts and identify mouse miRNAs that reach this threshold in vivo. bit.ly/44cYNvj

Community science presents an alternative discovery framework for precision ASO drugs. Puzzle games based on experimental data can empower players to come up with putative and intriguing precision drug designs. bit.ly/44u5oTv

RBP Footprint Bioinformatics Grand Challenge: evaluation of novel computational methods to identify RNA-binding protein footprints from structural data. bit.ly/4ekdgKL

OLE RNA dimers are depicted as integral membrane noncoding RNAs. This bacterial complex appears to penetrate membranes and mitigate cellular stresses. bit.ly/3FVn5Cd #ncRNA #RNAWorld @RonBreaker @lyon3131 @YaleMBB

The C-terminal domain of EDC4 scaffolds P-body assembly, and its disruption by the NBDY 22–41 peptide activates the p53 pathway and limits tumor proliferation, linking P-body dynamics to gene control. bit.ly/448qaGM

Discovery of a novel RNA polymerase III transcribed Alu RNA reveals a canonical and non-canonical tertiary structure and significant differences in association with the Alu RNA protein binding partner. bit.ly/3TFUrbf

Zika virus negative-strand synthesis requires interaction between SLA and the viral polymerase, NS5, but the complementary negative-strand structure, SLA´, is not needed for positive-strand synthesis. bit.ly/3GhvAHJ

Tpt1 removes an internal RNA 2'-PO4 by transferring it to NAD. This paper reports a crystal structure of Tpt1 bound to a 2'-PO4 RNA that illuminates principles of substrate recognition and catalysis. bit.ly/44hsYBv

Mutations in genes encoding RNA exosome subunits cause exosomopathies. A comparative analysis of yeast models reveals shared and unique transcriptomic changes, highlighting distinct consequences. bit.ly/44cWA2Z

Mice with cardiomyocyte-specific knockout of #YTHDF3 subjected to #cardiac stress had no increase in protein synthesis or cardiac hypertrophy. @Crabolli @AccorneroLab @OhioStatePCB @BrownMolBio bit.ly/4ekbfOH

Transfer RNA (tRNA) anticodon variants found in human genomes cause errors in protein synthesis, including mis-incorporation of alanine in proteins at threonine, glutamate, glycine, or valine codons. bit.ly/4lmF4QN

AGO1 is repressed by AGO2 and let-7 microRNAs during embryonic stem cell differentiation. bit.ly/4jdnehF

Circuit logic: interdependent RNA modifications shape mRNA and noncoding RNA structure and function. bit.ly/3H7eqfU