Anuj Kumar

For decades, how methanogenic archaea activate the MCR complex to produce methane remained a mystery. Today in Nature, we report the high-resolution cryo-EM structure of the MCR activation complex! 🥳🥳 nature.com/articles/s4158…

Take a moment to check the most recent publication by @AnujR2d2 et al., about the structure & mechanism of a major respiratory complex in anaerobes 👇🏼

Excited to share our latest work on the structure and mechanism of the ancient sodium-pumping Rnf complex, now out in @NatureComms nature.com/articles/s4146…

Very proud to share our latest work on the ancient the Na+-pumping Rnf complex – now out in Nature Comms. Thank you Schuller & Müller Labs for great collaboration, and @KAWstiftelsen for generous funding nature.com/articles/s4146…

Great work from my colleague @TomasPascoa

Our latest work on a #nitrogenase-like enzyme, the methylthio-alkane reductase which surprisingly also contains large nitrogenase metalloclusters, the P-cluster and the [Fe8S9C]- (L)-cluster is now online: doi.org/10.1101/2024.1… Have a look at the 🧵 by @AnaLagoMaciel.

I am honored and excited that our research on #nitrogenases and the conversion of #CO2 to hydrocarbons is highlighted in the Yearbook 2024 of the Max Planck Society, see page 29. An English and a German version of the Yearbook are available mpg.de/13631298/yearb….

New paper from the lab from @SriramGarg. We introduce a general substitution matrix for structural phylogenetics. I think this is a big deal, so read on below if you think deep history is important. academic.oup.com/mbe/advance-ar…

How do cells "decide" their fate from growth factor signals? Our new study introduces signaling homeorhesis — a dynamic alternative to homeostasis — to explain how cells interpret pulsatile signals into phenotypes. #CellBiology #CellSignaling

Nature research paper: Structure of the ATP-driven methyl-coenzyme M reductase activation complex go.nature.com/3Esgnmi

I'm truly excited to announce our new publication in @Nature unraveling a central picture of the Methyl-coenzyme M reductase (MCR) activation machinery and it's strong ATP dependency - kudos to @AnujR2d2 for the fantastic illustration! LINK: nature.com/articles/s4158…

This is a wild paper. The anaerobic biochemistry is definitely worth your while (and beyond me to explain), but let me try to explain why this is also an evolutionary bombshell. This is about how nitrogen fixation evolved as we know it.

Check out this fantastic thread from @fidelormz about out latest work out in Nature!! 🥳🥳

Two exciting papers about the the protection of nitrogenases from O2 by the ferredoxin Shethna protein II from the Tezcan doi.org/10.1038/s41586… and Einsle doi.org/10.1038/s41586… labs were published today by @Nature. Surprisingly both papers reveal superstructures of filaments.

I will be hiring officially later this year, but if you are interested in pursuing a Phd focused on metalloenzymes and infrared spectroscopy... Give me call!

Moreover, we will explore the role of [FeFe]-hydrogenase in multienzyme complexes, e.g., driving CO2 and CO reduction via H2 oxidation and electron bifurcation.

Excited to share our latest research on co-translational mRNA decay by the exosome in human cells! We uncover how the exosome-SKI complex is recruited to ribosomes and propose a novel role for SKI in recognizing collided disomes. @MPI_Biochem 👇👇👇

Great work by @BisLightyear