alexmag

Structures of GluK2 kainate receptor in complex with spermine and polyamine-containing toxins elucidate the trapping mechanism of channel block and provide a template for designing new drugs. @shantigangwar @MariaKarela3 @LauraYen42 @MKCMU nature.com/articles/s4146…

In collaboration with the Posthaus Lab, we identify ANTXR2—also the anthrax toxin receptor—as the receptor for Clostridium perfringens NetF pore forming toxin. Cryo-EM shows extensive contact between the pore and the receptor #Microbiology #CryoEM doi.org/10.1101/2025.0…

@TheBlanchardLab and I are looking for a driven postdoctoral fellow to lead our joint efforts combining single-molecule biophysics with cryo-EM to understand important mechanisms of novel genome-editors. We have a very exciting joint project that addresses key questions in the…

Happy to share our last work. Wadjet-I SMC hinges are gates allowing selective bypass of obstacles connected through ssDNA BUT are dispensable for extrusion of naked DNA. Great teamwork with @drhonsworth, Taschi at Gruber lab with James & @DNA_topology biorxiv.org/content/10.110…

In our latest work we visualize continuous motion of nucleosomal DNA by human chromatin remodeler SNF2H. biorxiv.org/content/10.110…

I‘m happy to share our work on laser flash melting to overcome preferred orientation in cryo-EM samples! 🥳❄️🔬 More infos on the underlying mechanism of particle redistribution and the use for preferred orientation issues in the 🧵 or here: biorxiv.org/content/10.110…

Initial results with nsTEM showed promising results also for the big proteins. So, we reached out to the fantastic @DCI_EM for cryoEM investigation and obtained high resolution structures for a 950 and 1000 AA protein,completly de novo designed! .

Thanks to everyone for the amazing response to BindCraft! 🔥🚀🖥️ Feel free to DM me or write on Github if encounter targets where the pipeline fails to generate binders, we want to use the feedback to improve it! P.S: here is a "helicopter" binder against DerF21 dimer

1/5 Happy to share our new preprint with co-first author @MeghnaG27 biorxiv.org/content/10.110… @lab_stroud, @GuptaLab_, James Gomez, Sulyman Barkho, Ziqiang Guan, Ashley Eng, Tomo Kawate, Sree Ganesh Balasubramani, @salilab_ucsf, Deborah Hung, Robert M. Stroud @ChiefKingfish.

It was a great pleasure to visit the amazing Dubochet Center for Imaging @DCI_EM at EPFL Lausanne 🇨🇭 and give a keynote talk for their inaugural symposium. What an impressive set of equipment and a panel of top-notch specialists!! Thank you @AlexmagCryo for the invitation 🙏🙏

Come join us at EPFL! We are looking to fill a new position for a Tenure Track Professor in Chemical Biology! Find all info how to apply here: epfl.ch/about/working/…

Happy to announce our new preprint done in collaboration with @matteodp and @chancao123 labs

100,000's of our #cryoEM Autogrid Rings have been used since 2023 without issue. They're inspected w/multiple processes, including a visual inspection of every ring by experts.Our passion to make the best rings is evident in quality&package!See them #MM2024 @MiTeGen @TedPellaInc

I'll be in Lausanne next Monday, will finally visit the Dubochet Center for imaging &co, Henning @LabStahlberg. Very excited, come to see my talk if around