Alex Shcheglovitov 🇺🇦
@AlexShcheglovit
Associate Professor @shcheglovitov @UUNeurobiology @UUtah studying human 🧠 development in health and disease using #iPSC & #organoid
📣 Our protocol to generate brain #organoids from #StemCell derived Single Neural Rosettes 👇
Our lab generates brain organoids from isolated single neural rosettes - and now it's all in a new @NatureProtocols paper! Step-by-step instructions to try it yourself👇 doi.org/10.1038/s41596… #Organoids #Neuroscience #StemCells
Really interesting study on social information processing in the prefrontal cortex 👇
Excited to see this in print this morning, coincidentally on the lab's birthday! Here we tackle the question of how the PFC multiplexes social and contextual information using overlapping ensembles of neurons. doi.org/10.1038/s41467…
Brain cancer leverages the same tools as the developing brain 🧠! In our new study, published today in @Nature, we mapped neocortical development to explore brain cancer and neuropsychiatric risks. #stemcells #brainresearch nature.com/articles/s4158…
Temporally distinct 3D multi-omic dynamics in the developing human brain | Nature nature.com/articles/s4158…
This is a cool one. We leveraged single cell analysis and in vivo calcium imaging to examine how ASD risk gene Shank3 alters the activity of heterogeneous cell populations during anxiety. Congrats to Hailee,@damhyeonkwak , and Prakash! biorxiv.org/content/10.110…
NIH announces end to funding for animal-only studies drugdiscoverytrends.com/nih-announces-…
New Article! Generating and characterizing human telencephalic brain organoids from stem cell-derived single neural rosettes bit.ly/40onGmE
Great analytics! Indeed, it is “brutally difficult” to do rigorous biomedical research and cutting NIH funding may have detrimental consequences. “Cutting science won’t balance the budget—but it might bankrupt our future.”
So, should we reduce academic science spending? The data is unequivocal: we should increase it. linkedin.com/pulse/what-hap…
Delighted to share our most recent preprint led by the incredible @MilJessenya and @Jalbsoto! In this study, we generated a metabolomic atlas of human cortical development and discovered that the pentose phosphate pathway regulates radial glia cell fate. biorxiv.org/content/10.110…
Great meeting- highly recommend!! 👇
We are excited to continue the GRC on Functional Genomics of Human Brain Development and Disease in April 2025. Please check out the great line-up of speakers. Oral presentation slots and poster presentations are still open! Deadline March 9th grc.org/functional-gen…
Way to go @arif55dml !!👏👏
@arif55dml presented his research project at CSHL meeting on brain #organoids! Thanks @Sergiu_P_Pasca and @UPenn_SongMing for the opportunity!
Examine multimodal data from thousands of cells across three mammalian species with the Cell Type Knowledge Explorer, an open science resource developed with BICCN and supported by the BRAIN Initiative Alliance. Explore it at: knowledge.brain-map.org/celltypes #BICCN #studyBRAIN
🔬 Are you eager to dive into the world of light microscopy and learn from top-notch microscopists about its essential techniques for life science applications? If that sounds exciting, don’t miss out on this free, in-depth iBiology series! 👉 ibiology.org/online-biology…
In @CellCellPress, I share a major conceptual challenge for biology in the next decade, inspired by Crick’s Central Dogma: understanding information flow in the cell, the smallest indivisible unit of life bit.ly/4hQMmva
1/3 Exciting News! We're hiring at all levels immediately for our lab @UUNeurobiology Join us in cutting-edge research at the intersection of neuroscience and chemical biology! We aim to explore how neuropeptides modulate behavior and physiology. Pls RT!
Mind blowing 🤯 Adding this to my reading list!
Today we introduce human neural loop #assembloids created from 4 parts derived from stem cells to study the cortico-striato-midbrain-thalamo-cortical pathway and to model neurodevelopmental disease Work led by the remarkable Ji-Il Kim and Yuki Miura in the lab. Also in…