Stephen Quake

@StephenQuake

Chief Science Advisor @chanzuckerberg | Professor of #bioengineering and Applied Physics @stanford | Prolific inventor at the nexus of #biology, #physics, #tech

Joined March 2021

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Stephen Quake@StephenQuake · Nov 22

Combining transcriptomic and metabolomic data from urine holds promise for improving early disease detection, subtyping, and prognosis, as well as enhancing our understanding of disease mechanisms. Read the paper in Clinical Chemistry: lnkd.in/gcJYJkgc

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Stephen Quake Retweeted

Chan Zuckerberg Initiative@ChanZuckerberg · Jun 27

“It’s going to be a very powerful tool for understanding what goes wrong in disease,” says @StephenQuake. “Our goal is to create computational tools so that cell biology goes from being 90% experimental and 10% computational to the other way around.” nature.com/articles/d4158…

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Stephen Quake@StephenQuake · May 21

Honored to be elected a Fellow of the @royalsociety. Grateful for the collaborators and mentors who’ve made this journey possible, and proud to keep pushing science forward. royalsociety.org/news/2025/05/n…

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Eric Topol@EricTopol · Mar 18

What is considered to be the holy grail of biology—the virtual cell—now has potential for being actualized. erictopol.substack.com/p/the-holy-gra…

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Stephen Quake@StephenQuake · Mar 11

Preprints have transformed how we share research. Now, openRxiv is poised to elevate preprint infrastructure with sustainability and researcher-led governance. #OpenScience czi.co/4hbxPIY

StephenQuake's tweet card. An interview with openRxiv Board Chair Scott Fraser.

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Stephen Quake@StephenQuake · Jan 6

Each year, I share a favorite book with my @cziscience team. This year is Cork Dork by @bbosker. A fascinating exploration of the world of wine, it inspires an appreciation for the neuroscience of taste and the passionate pursuit of knowledge. #CZIScience #teamgift #wine

StephenQuake's tweet image. Each year, I share a favorite book with my @cziscience team. This year is Cork Dork by @bbosker. A fascinating exploration of the world of wine, it inspires an appreciation for the neuroscience of taste and the passionate pursuit of knowledge.
#CZIScience #teamgift #wine

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Stephen Quake@StephenQuake · Dec 19

Joe DeRisi has been busy! From SARS-1 identification to increasing the clinical utility of metagenomic tools, he’s being honored with the @StanfordMed Arthur Kornberg & Paul Berg Lifetime Achievement Award—well deserved! bit.ly/3VJcbUt

StephenQuake's tweet image. Joe DeRisi has been busy! From SARS-1 identification to increasing the clinical utility of metagenomic tools, he’s being honored with the @StanfordMed Arthur Kornberg &amp; Paul Berg Lifetime Achievement Award—well deserved! bit.ly/3VJcbUt

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Stephen Quake@StephenQuake · Dec 18

Tabula Sapiens 2.0, a reference atlas with >1.1 million cells from 28 human tissues, reveals insights into transcription factor expression, cell senescence, & sex-specific gene expression. Explore the findings: biorxiv.org/content/10.110…

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Stephen Quake@StephenQuake · Dec 17

Cross-pollinating people and ideas between countries is key to solving scientific challenges, which is why we are partnering with the @ss_f_official to bring great scientific talent to the U.S. and Japan through a new fellowship bit.ly/4gkZkAq

StephenQuake's tweet card. Apply for the new international postdoctoral fellowship program from the CZ Biohub Network and Stellar Science Foundation.

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Stephen Quake@StephenQuake · Dec 16

This year we worked with scientists & #AIML experts to create a vision for the future of virtual cells. Now in @CellPressNews, the vision shares a roadmap for large-scale, collaborative research on AI-supported virtual cells. This is just the beginning bit.ly/4gzocUL

StephenQuake's tweet card. Advances in AI and omics enable the creation of AI virtual cells (AIVCs)—multi-scale, multimodal neural network models that simulate molecules, cells, and tissues across diverse states. This vision...

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Stephen Quake@StephenQuake · Dec 10

Excited to get ski season started this weekend. A bluebird day and spring conditions at Palisades!

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Stephen Quake@StephenQuake · Dec 9

Virtual cell models have the potential to transform biological research. Today @ChanZuckerberg released an initial set of models, including scGenePT and SubCell, designed to be easy to run and build upon. This is a really exciting time in biology. czi.co/4g1jTSa

StephenQuake's tweet card. We’re making it easier for biologists and machine learning researchers to collaborate with cell models that are easy-to-use + build upon to accelerate the next big breakthrough.

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Stephen Quake@StephenQuake · Dec 5

New @ScienceMagazine : #CZBiohubCHI's biosensor continuously measures proteins in vivo. In a diabetes model, it resets in under a minute, enabling real-time cytokine tracking. A breakthrough for inflammation-related diseases. czi.co/4giRO8v

StephenQuake's tweet card. Implantable device provides an impactful new way to monitor health and disease

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Stephen Quake@StephenQuake · Dec 3

The convoluted language of cells is a ripe challenge for AI. With the extensive collection of biological data, the possibility of predictive models of cells and cell systems is on the horizon, and cell biologists will be key to bringing this to fruition. bit.ly/49ekSMd

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Stephen Quake@StephenQuake · Dec 2

Had a great conversation with my student @sevahnv on the @myADLM podcast about work she led exploring cell-free RNA in urine as a path to avoid invasive biopsies for detecting diseases earlier in prostate, kidney and bladder tissues bit.ly/3B3MOFV

StephenQuake's tweet image. Had a great conversation with my student @sevahnv on the @myADLM podcast about work she led exploring cell-free RNA in urine as a path to avoid invasive biopsies for detecting diseases earlier in prostate, kidney and bladder tissues bit.ly/3B3MOFV

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Stephen Quake@StephenQuake · Nov 14

In @CellCellPress, I share a major conceptual challenge for biology in the next decade, inspired by Crick’s Central Dogma: understanding information flow in the cell, the smallest indivisible unit of life bit.ly/4hQMmva

StephenQuake's tweet image. In @CellCellPress, I share a major conceptual challenge for biology in the next decade, inspired by Crick’s Central Dogma: understanding information flow in the cell, the smallest indivisible unit of life bit.ly/4hQMmva

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Stephen Quake@StephenQuake · Nov 12

Manual annotation of cryoET data is a major bottleneck in biomed research. The #CZImagingInstitute Kaggle Challenge seeks #AIML innovators to automate particle detection in 3D cell images. Share with ML/AI experts: bit.ly/4hqCFn2

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Stephen Quake Retweeted

Chan Zuckerberg Initiative@ChanZuckerberg · Oct 21

Supporting diversity in science is key to advancing research. Our Science Diversity Leadership Award provides funding for researchers driving equity in biomedical fields. Learn more and apply: czi.co/SDL

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