Arun John Peter
@ATJohnPeter
Assistant Professor, University of British Columbia @UBCcps @ubclifesciences | Lipid trafficking, membrane contact sites & organelle homeostasis
I am happy to share that I've begun my new role as an Assistant Professor @UBC in the Department of Cellular and Physiological Sciences @UBCcps @ubclifesciences The lab will explore the mechanisms of lipid transport and lipid quality control in organelles 1/4
It is finally out! I am incredibly proud to share that my work has officially been published in Cell @CellCellPress! This work was a product of years of dedication and countless hours of research in the labs of Joanna Wysocka and @JaroszLab @StanfordMed cell.com/cell/fulltext/…
Have you ever wanted to design protein binders with ease? Today we present 𝑩𝒊𝒏𝒅𝑪𝒓𝒂𝒇𝒕, a user-friendly and open-source pipeline that allows to anyone to create protein binders de novo with high experimental success rates. @befcorreia @sokrypton biorxiv.org/content/10.110…
2. The work from @sriraksha616, @dani_alv4 and @ATJohnPeter on identifying lipid binding pocket for lipid transport proteins ( link👇) is out in @JCellBiol! We have added "a lot" of stuff since our preprint. All files and protocols are in Zenodo, give it a try and let us know!
Sriraksha Srinivasan, Daniel Álvarez, Stefano Vanni et al. @LabVanni @unifr develop a fast and easy-to-use protocol based on coarse-grained #moleculardynamics simulations to characterize #lipid binding to lipid transfer proteins. hubs.la/Q02KfsXq0 #lipids #biophysics
Here is our short review on METALIC and its potential to understand lipid traffic in vivo febs.onlinelibrary.wiley.com/doi/full/10.10…
Ever wonder why cells of the same type tend to have a pretty uniform size? Check out our new paper out in @MolecularCell today to find out why too big can be a bad thing in terms of genome homeostasis and proliferative potential. 🧵 (1/9) cell.com/molecular-cell…
Amazing scientists, great discussions & a wonderful location in Barcelona #EMBOlipidDroplets
This beautiful study caught different lipid transfer proteins in the act, revealing striking similarities in their mode of action!
Thrilled to share the latest preprint from the lab! This was a MD simulation tour-de-force from @sriraksha616 and @AndreaDiLuca7, probably the most MD data-rich study in my career. If you are interested in lipid transport and homeostasis follow along! A #lipidtime 🧵: (1/9)
Cool new strategy to visualize PM-ER lipid traffic!
We (Dongjun Liang and Lin Luan) harness chemoenzymatic tagging & super-fast #bioorthogonal chemistry to make fluorescent lipids that report on PM-to-ER phospholipid flux mediated by a dedicated family of lipid transfer proteins at these contact sites! 2/2 doi.org/10.1101/2023.0…
When too many cooks rock the broth!
8 hands, 1 guitar.. Amazing..
You can make a glass sing with your fingers, but can you play Sugar Plum Fairy by Tchaikovsky? The Glass Duo did it, among the other impressive performances [full video and more: buff.ly/37cetm7] [the physics behind the sound: buff.ly/36UkOCo]
A membrane sensing mechanism couples local lipid metabolism to protein degradation at the inner nuclear membrane biorxiv.org/cgi/content/sh… #biorxiv_cellbio
I am super happy to share that the first paper of our lab is out in @JcellBiol!!! “Cvm1 is a component of multiple vacuolar contact sites required for sphingolipid homeostasis”. It is a🧵👇
In this Article Commentary in @ContactCTC, we think aloud on how the conserved bridge-like lipid transport protein Csf1 is involved in lipid remodeling and homeoviscous adaptation @YaanJang @BenoitKornmann journals.sagepub.com/doi/full/10.11…
This is so cool!! METALIC (Mass tagging-Enabled TrAcking of Lipids In Cells), a method to track interorganelle lipid flux inside cells, is used to study ERMES and Vps13 lipid transport function. Amazing @ATJohnPeter @BenoitKornmann! 🤩🔥👏 nature.com/articles/s4155…
Our study demonstrating a new versatile strategy to monitor lipid transport in vivo is out in Nature Cell Biology nature.com/articles/s4155… @PeterLab8 @BenoitKornmann @KornmannLab Big thanks to @LabVanni for great support during the completion of this work!
Supervisor asking a post doc to help with reviewing a paper