Nathan Poongavanam
@vasanthanathan
Computational Chemist, Interested in Natural Science and AI, Copenhagen | Vienna | Odense | Uppsala
Glad to share our new article on the #hydrophobic #collapse of #PROTACs ! pubs.acs.org/doi/10.1021/ac…
Sign up for the GPCR workshop at AstraZeneca (Gothenburg), 6th of May! Please share this information! Sign up here: insingulo.com/registration
Spread the news to anyone who might be interested! The SciLifeLab #pulse #PostdoctoralFellowship Program is now open for applications! Focus Areas: ML/AI, Oligonucleotides, more.. scilifelab.se/research/pulse/ #DrugDiscovery #machinelearning #AI #jobs #postdocopportunity #sweden
A membrane permeability database for nonpeptidic macrocycles nature.com/articles/s4159… #DrugDiscovery #Macrocycles #MembranePermeability #caco2 #MDCK #RRCK #ER
New Publication Alert! Excited to share our latest publication in Scientific Data: “A membrane permeability database for nonpeptidic macrocycles” by QIUSHI FENG, Danjo De Chavez, Jan Kihlberg
Impact of Linker Composition on VHL PROTAC Cell Permeability | Journal of Medicinal Chemistry pubs.acs.org/doi/full/10.10…
We’re thrilled to share our latest research exploring the solution ensembles of #PROTACs in nonpolar solvents and their impact on #cell #permeability! Check out the full paper lnkd.in/dpa_nV59 #DrugDiscovery #PROTACs #NMR #conformation #chemicalmodalities #CompChem#bRo5
We emphasize the danger of rules that provide a false impression of the #lipophilicity required of a #clinical #candidate. Beware of extreme calculated lipophilicity when #designing #cyclic #peptides- #Nature Chem Bio, 20, 1242–1245, 2024. nature.com/articles/s4158…
The application period for the SciLifeLab #PULSE postdoc program is approaching (opening on January 7), and we are excited to share a matchmaking portfolio where candidates can browse SciLifeLab Group Leaders interested in hosting a #PULSE #postdoc. #ai #MachineLearning #protac
Apply for a postdoc position in my group via the SciLifeLab PULSE program. Contact me if your have questions! scilifelab.se/research/pulse…
Looking for a postdoc (pharmacology) to join one of our exciting projects focused on G protein-coupled receptors. Experience in signalling assays is required. You will be working in an interdisciplinary team to understand the activation mechanism and design ligands. Contact me!
Just How Lipophilic Is That Huge Thing? | Science | AAAS science.org/content/blog-p…
BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
Are you or someone you know looking for the next step in your research career? SciLifeLab PULSE is a prestigious postdoc program connecting brilliant researchers with incredible opportunities in academia and industry. #SciLifeLab #PULSE #DDD #PostDoc #comchem #nmr #Sweden
We are excited to share our latest #Comment in #NatureChemicalBiology "Beware of extreme calculated lipophilicity when designing cyclic peptides". lnkd.in/dBmfTceJ Thanks Duy and Jan Kihlberg #CyclicPeptides #Lipophilicity #Nature #CompChem #AI #cLogP
PROTAC DB 3.0🎊
PROTAC-DB 3.0: an updated database of PROTACs with extended pharmacokinetic parameters academic.oup.com/nar/article/do…
Interested in molecular dynamics simulations, free energy calculations, enzymes and evolution? My colleague Johan Åqvist is recruiting postdoctoral researchers, apply here: uu.varbi.com/en/what:job/jo…
Can AlphaFold be useful in drug discovery? Hell yes! In our paper, structure-based virtual screens using AlphaFold models identify potent GPCR ligands with antipsychotic effects in vivo (science.org/doi/10.1126/sc…). @KAWstiftelsen @UU_University @karolinskainst @scilifelab
Opportunity for molecular modeler at Galapagos (Mechelen Belgium) #CADD #CompChem #cheminformatics #EUChemJobs #ChemJobs workatgalapagos.com/join-us/comput…