Harry Low’s Lab
@thelowlab
Bacterial pathogenesis. Antibiotic discovery. Membrane remodelling. Structural biology #cryoEM @imperialcollege @lowlab.bsky.social
Now out in NSMB for those who missed our biorxiv back in 2023.. rdcu.be/dZSPQ
The missing piece in the bacterial #ESCRT-III story.. #Vipp1 forms dynamic spiral filaments on membrane! Spirals are springs that drive 3D ring formation in the spiral centre! 😎😵💫 Wonderful collaboration with @Colom_D @RouxLab… 1/2 biorxiv.org/content/10.110…
Postdoc position available! This is a 2-year post funded by the Academy of Medical Sciences. You'll be based in the Centre for Bacterial Cell Biology here in Newcastle, using super-resolution microscopy to look at the bacterial cell wall. 🔬🦠 RT 🙏 jobs.ac.uk/job/DMY885/res…
This is jaw dropping level stuff!
Excited to share our pre-print on the molecular architecture of heterochromatin in human cells🧬🔬 w/ @jpkreysing, Johannes Betz,Turoňová lab, @MarinaLusic, Hummer lab, @Beck_Laboratory, @MPIbp 🔗 Preprint here: doi.org/10.1101/2025.0…
❗️ Exciting review alert❗️focussing on the evolution and mechanism of prokaryotic ESCRT-III-like systems.. fun collaboration with Tom Williams! doi.org/10.1016/j.sbi.…
We are looking for an Assistant Professor / Lecturer in Molecular Microbiology @ImperialInfect @CBRB_Imperial. All areas of bacterial/fungal infection biology considered. Details👇. Please contact me by email for any further information. imperial.ac.uk/jobs/search-jo…
The Beeby lab's magnum opus on the Campylobacter flagellum is out. This is a uniquely powerful flagellum and how it evolved out of simpler precursors will keep us busy for a while still. Check it out! nature.com/articles/s4156…
Brilliant🔥
Exciting findings from @JunLiuLab #postdoc @YueJianUSTC @YaleMed Architecture and activation of the Legionella Dot/Icm type IVB secretion machine #cryoEM #cryoET #Legionella biorxiv.org/content/10.110…
Looking for a fully-funded D. Phil. / Ph.D. studentship in structural biology and vaccinology? Come to join our team. Fully and generously funded by a donation from the Kyner-Field family with full fees at overseas level. Join us?? bioch.ox.ac.uk/studentships
We have a funded #PhD project working on RSV, antibodies and computational biology. Deadline 30th June imperial.ac.uk/medicine/study…
We describe why Hfq forms condensates in nitrogen starved E.coli by @JoshMcquail and colleagues: biorxiv.org/content/10.110…
Please RT. Post-doc opportunity alert! 💥 closing 5th May.. Come join our team (thelowlab.org) at Imperial, London, working on bacterial secretion systems. The position is funded by the Wellcome Trust. For more details and to apply please see imperial.ac.uk/jobs/search-jo…
More awesome cryo-ET from the Liu lab unravelling flagella motor architecture..
MotE-like proteins, including FlgY in Campylobacterota and FlbB in Spirochaetota, form characteristic ring structures across bacterial phyla. journals.plos.org/plospathogens/… biorxiv.org/content/10.110… pnas.org/doi/10.1073/pn…
Our Postdoc recruitment call will close in 2 weeks time. Please feel free to get in touch! Apply here: mrc.tal.net/vx/mobile-0/ap… #postdoc #research
🚨 PostDoc opportunity at the MRC-LMB 🚨Join our team to explore transcription-coupled splicing using cryoEM and biochemistry! 🔬🧬 Please spread the news 🙏🏼 Apply here: mrc.tal.net/vx/mobile-0/... #Postdoc #CryoEM #MolecularBiology #Cambridge
Please RT. Post-doc opportunity alert! 💥 Come join our team (thelowlab.org) at Imperial, London, working on bacterial secretion systems. The position is funded by the Wellcome Trust. For more details and to apply please see imperial.ac.uk/jobs/search-jo…
We are looking for a PhD student/Postdoc to develop methods of cryo-ET and/or study the structure and function of membrane proteins. Great team at the MDC in Berlin. It's a broad call, please apply and share! jobrxiv.org/job/max-delbru…
This may be the structural basis for interspecies transmission barriers, but it also suggests that these barriers are not absolute, and can be overcome.
In this narrative review at @JNeurochem I propose that independent misfolding subdomains in PrP of different host species support prion diversity lacking any universally conserved conformational motifs across those species. Check it out! onlinelibrary.wiley.com/doi/full/10.11…
In this narrative review at @JNeurochem I propose that independent misfolding subdomains in PrP of different host species support prion diversity lacking any universally conserved conformational motifs across those species. Check it out! onlinelibrary.wiley.com/doi/full/10.11…
Excited to share our new preprint on co-transcriptional splicing! U1 snRNP is recruited to RNA polymerase II through multiple interaction sites, with elongation factor SPT6 binding directly to the U1 snRNP protein. biorxiv.org/content/10.110… #cryoEM #transcription #splicing
Please repost: Postdoc position in antibiotic discovery in a multidisciplinary project w. high-throughput approaches, microscopy, AI, and hit-to-lead optimization @UMontreal @med_umontreal @Mila_Quebec @IRIC_umontreal. Apply @ [email protected]. See lnkd.in/dVVk4N3s