Nikos Vakirlis
@vakirlis
G4 Group Leader at Hellenic Pasteur Institute. Evolution, genomics, bioinformatics. We mostly study how new genes are born and what they do.
🧬🚨New in @TrendsGenetics: Our review on microproteins in cancer! From identification to clinical potential, discover how these tiny proteins are reshaping cancer biology here: authors.elsevier.com/sd/article/S01… @s_heesch @johnprensner #microproteins #CancerResearch
Our latest: Orphan genes are not a distinct biological entity. Orphan genes, aka loci with no homologous genes outside a focal taxon, are widely used as proxies of lineage-specific genes that are important for adaptation and innovation. onlinelibrary.wiley.com/doi/10.1002/bi…
Thank you Mar, it was fantastic to have you! Shout out also to co-organizers @guilderstern @alxndrs_pittis @TerezaManousaki and Greg Amoutzias
Back in Barcelona after having spent four fantastic days at the #EMBOEvoCompGenomics in Nafplion Greece. Great to meet colleagues and learn about so many exciting projects from PhD students and postdocs. Big shout out to the organizers @vakirlis!
At the @EMBO lecture course on evolutionary genomics. Great science with great views in Nafplio, beautifully organised by @vakirlis @TerezaManousaki, Alex Pittis, Grigoris Amoutzias & Christophoros Nikolaou. It's now my time to tell everyone about the research from my lab! 🧬🪱
First day recap of #EMBOEvoCompGenomics. Two very inspiring talks from @maralbasoler and @bornberglab for microproteins and de novo genes respectively. Poster session then followed with many interesting works being displayed. Excited for day two. @vakirlis @guilderstern
It's almost time!! We're at our wonderful venue getting ready for our @EMBOevents EMBO Lecture Course Evolutionary and Comparative Genomics #EMBOEvoCompGenomics @guilderstern @ETassios
Very excited about our recent work with @anne__lopes exploring the ribosome profiling landscape of yeast and detecting pervasively translated ORFs! Published in @GenomeBiology! 🧬 genomebiology.biomedcentral.com/articles/10.11…
Beautiful yeast (+1 algae) scientific family #EMBOEvoEco
What a nice way to say goodbye! Our latest work is now online on @AgingCell. Our study shows how Cockayne Syndrome B protein is implicated in transcription and chromatin dynamics in homeostatic and genotoxic conditions! onlinelibrary.wiley.com/doi/full/10.11…
Happy to share our new manuscript published in @NatureCVR! 1) Curious about how genes, small open reading frames (sORFs) and microproteins evolved in primates? We explored how these elements shaped the cardiac transcriptomes and translatomes of primates. nature.com/articles/s4416…
Hold on to your hats! The winners of the 2024 #NikonSmallWorldInMotion competition have finally been revealed, and they're sure to blow you away. View the full video gallery here: bit.ly/47t3L8A
I am delighted to share our latest preprint: biorxiv.org/content/10.110… where we compared the transcriptional pattern of Small Secreted Peptides (SSPs) in the pathogen-induced transcriptomes of vascular and non-vascular plants #peptides
DENSE is out and ready to mine your favorite genome for its de novo genes! Try it out! academic.oup.com/gbe/article/16…
Looking for a PhD position in 2025? 🧑🎓 Interested in endometriosis research? 🩸 We are looking for a computational candidate for the Pasteur-Paris University PhD program to join a fantastic international collab between my lab, @afilimon and L. Doridot! Please RT!
Last chance! Registration closing this week.
Registration for our EMBO course in gorgeous Nafplion, Greece is open! With an excellent lineup of speakers and really affordable fees, this is a great deal for PhDs and postdocs. Please help spread the word! #EMBOEvoCompGenomics
My latest collaboration with the one and only Anne-Ruxandra @carvunis is out in @GenomeBiolEvol ! Can we determine if/when a gene was born de novo by reconstructing its evolutionary past? We tried 👇
Registration for our EMBO course in gorgeous Nafplion, Greece is open! With an excellent lineup of speakers and really affordable fees, this is a great deal for PhDs and postdocs. Please help spread the word! #EMBOEvoCompGenomics
⬇️Now published in @GenomeBiolEvol! This marks the end of my master’s thesis at @bornberglab 🥲 But off to new adventures at @CRGenomica 🥳 academic.oup.com/gbe/article/16…
What structures do de novo proteins have? What are their functions? How does their sequence space localization aid in understanding their properties? Find out in the 2nd preprint from my master’s thesis together with @lacholt & @bharatravi654 🧵1/10 biorxiv.org/content/10.110…
Been talking about issues of this paper with colleagues in meetings during the past year, glad someone took the time to address it. nature.com/articles/s4155…