Theo Jalabert
@theo_jala
product engineer @adaptyvbio - building software for protein design
We’re approaching the “garage moment” in biology, where it becomes possible for individual protein designers to design potentially world changing therapeutics from their garage with nothing more than a laptop and an internet connection
Protein designers should be designing, not pipetting. AI models like AlphaFold, RFdiffusion & co make it easy to design new proteins. But a protein on the computer isn’t worth much by itself. At @adaptyvbio we’re building a platform that allows you to actually test your…
as it was written in the ancient texts
OpenAI is prepping the next generation of its o1 reasoning model. But, due to a potential copyright/trademark conflict with British telecommunications firm O2, OpenAI has considered calling the next update “o3” and skipping “o2." More here w/ @amir: theinformation.com/briefings/open…
Chai Discovery just released their new model Chai-2, validated on Adaptyv! Chai-2 enables generation of de novo proteins and epitope-specific antibodies using a multimodal generative architecture that integrates all-atom structure prediction and generative modeling. Chai…
We’re excited to introduce Chai-2, a major breakthrough in molecular design. Chai-2 enables zero-shot antibody discovery in a 24-well plate, exceeding previous SOTA by >100x. Thread👇
We're looking for talented people to join our team! Adaptyv is growing super fast and we need more hands on deck to manage our lab, BD and ops! Please send me a DM if you have recommendations for who we should hire
We're hiring! Come work with us to democratize protein engineering. At Adaptyv, our high-throughput cloud lab enables protein designers to experimentally validate their proteins with the click of a button. We're building advanced molecular biology workflows, assay automation…
We're hiring! Come work with us to democratize protein engineering. At Adaptyv, our high-throughput cloud lab enables protein designers to experimentally validate their proteins with the click of a button. We're building advanced molecular biology workflows, assay automation…
Pro-1, a protein design model by @hla_michael, doesn’t just propose mutations — it explains why it made them. We tested 19 of its FGF-1 designs in our lab and 3 of them improved thermostability while maintaining binding. In this protein designer spotlight we explain how…
Thanks to the efforts of all the amazing people in the protein design community we managed to write up a cool paper after our protein design competitions at Adaptyv. One of the key takeaways was: to design better proteins we need better models and those models need better data.
Introducing BenchBB and the community paper of the Protein Design Competition 🎉 We wrote a community paper about our Protein Design Competition, teaming up with your favourite protein designers from both rounds. Excited to announce that this is now on Biorxiv 🙌
Introducing BenchBB and the community paper of the Protein Design Competition 🎉 We wrote a community paper about our Protein Design Competition, teaming up with your favourite protein designers from both rounds. Excited to announce that this is now on Biorxiv 🙌
It's so cool how @v0 + @supabase make it easy for scientists to build their own software 🧪💻 Today we ran an internal hackathon at @adaptyvbio where we "forced" everyone to use AI tools like v0 & co to solve problems we have in our lab Our head of biosensing, who at 49 y/o has…
Can you build this? Then come work with us at @adaptyvbio. Adaptyv is the cloud lab for protein designers. Our high-throughput wet lab enables protein designers to experimentally validate their proteins with the click of a button. We're building advanced molecular biology…
@MSFTResearch's @SarahAlamdari was speaking at @appliedmldays in Lausanne today. Good timing to showcase how their team was using our lab to validate their new protein design model, EvoDiff 💡🧬 More details below!
Come meet me in SF this week at JPM! @adaptyvbio is the cloud lab for protein designers — you design proteins with AI and our automated wet lab will characterize them. Send me a DM if you want to meet and talk about data generation to improve your protein design models!
Just before the New Year: BindCraft v1.5! Please fill out this form to request new features and help us make BindCraft even better. forms.gle/XsGHDCyHtczVba…
new blogpost: What we learned about binder design from the Adaptyv competition blog.booleanbiotech.com/what-we-learne…
Has protein binder design been solved? We analyze the results of our protein design competition where 130 designers created binders for EGFR. With a 5x improvement in success rates and some designs outperforming clinical antibodies, we explore what worked, what didn't, and what…
Few more new PDBs released from us before the end of the year :)