Taylor Mighell
@taylor_mighell
EMBO Postdoc Fellow with @BenLehner at @CRGenomica. GPCRs, synthetic biology, genomics, machine learning, tech development. Alum @ngpohsu. He/him.
Very happy to have the first version of the manuscript from my PhD work in @BigSpinLab out!We identify a novel function of the classical NF-κB inhibitor IκBα in regulating pluripotency heterogeneity in mESCs @HMar_research @CarrerasIJC @biorxiv_cellbio #pluripotency #development
Epigenetic modifications driving ground state pluripotency exit require an NF-κB-independent chromatin IκBα function biorxiv.org/cgi/content/sh… #bioRxiv
Very happy to share what I've been working on in Barcelona with @BenLehner ! We made many (>400k) mutations in a disordered peptide and the globular domain it interacts with to gain a comprehensive map of how specificity is encoded in a partially fuzzy protein interaction (1/n)
Excited to share @taraneh_z's preprint: A complete map of specificity encoding for a partially fuzzy protein interaction biorxiv.org/content/10.110…
We presented the first global map of inhibitory allosteric sites for any protein here KRAS and the first comprehensive comparative map of the effects of mutations on the free energies of binding of a protein to multiple partners. nature.com/articles/s4158…
Excited to finally share some of my PhD work on quantifying the effects of indel mutations on protein stability and function using deep mutational scanning. From sunny @CRGenomica together with @ToniBeltran13 and guidance from @BenLehner biorxiv.org/content/10.110…
New preprint from the lab: Deep indel mutagenesis reveals the impact of insertions and deletions on protein stability and function. First paper from Magda with @ToniBeltran13 biorxiv.org/content/10.110…
Time to share my PhD work where we quantified the translational readthrough of thousands of pathogenic stop codons and trained predictive models to predict drug-induced readthrough of any stop codon. With the priceless guidance from @FranSupek +@BenLehner! biorxiv.org/content/10.110…