Hyeyoung Shin
@shinehyeyoung
neuroscientist studying neocortical dynamics underlying perception. Assistant Professor at Seoul National University
How does neural variability affect coding efficiency and robustness? We found that while the intrinsic neural variability structure is suboptimal for coding efficiency, it is, in fact, optimal for robustness! biorxiv.org/content/10.110…
~30 years of research in non-behaving animals argue that bilateral touch integration likely occurs downstream of primary somatosensory cortex. We reveal the state- and task-dependent logic that unlocks communication between S1s through the corpus callosum. nature.com/articles/s4159…
Video thread containing the individual videos that accompanied the MICrONS paper package out last week. Not science explainer videos, more like "A trailer for a paper...Not intended to be a replacement for reading, but hopefully they make you want to: nature.com/immersive/d428…
What’s particularly unique about the MICrONS mouse is the matched functional imaging and EM connectivity data, which enabled us to study structure–function relationships. Tyler Sloan created this beautiful film to illustrate this.
And last but not least, the mic-drop moment of functional connectomics. “Cells that fire together”, or to be more exact: ”Neurons with higher signal correlation are more likely to form synapses.”
After 7 years, thrilled to finally share our #MICrONS functional connectomics results! We recorded activity from ~75K neurons in visual cortex in a single mouse, then mapped its wiring using electron microscopy. To systematically characterize neuron function, we built the first…
I'm happy to share the final version of our paper in @Nature this week, with a lot of new data! 📄: nature.com/articles/s4158… This would have been impossible without support from the NIH (especially BRAIN Initiative), as well as @HHMINEWS, @SimonsFdn, @PrincetonNeuro, HHWF, BRF.
How do we associate the flavors we experience during a meal 🍽️😋 with postingestive effects, like food poisoning 🤢🤮, that arise minutes or hours later? My new preprint with @IlanaWitten digs into how the brain solves this credit assignment problem. 1/4 biorxiv.org/content/10.110…
Very proud of this new preprint of a study by Conor Dorian and co-led by Golshani and Buonamano labs. We find that hippocampal neurons can encode both working memory and implicit timing. biorxiv.org/content/10.110…
A magical day celebrating @KarlDeisseroth's Asan Award in Medicine! 🇰🇷🎉 Watch this great video illustrating his achievements: youtube.com/watch?v=tOzKu8… Deeply grateful and inspired. Congrats again, Karl! #AsanAward #Optogenetics #Neuroscience
Folks! We need your help to establish this platform long term for everyone! Can you help us out spread this video? youtube.com/watch?v=13r9n0…
TOMORROW - Join us for our 2025 OpenScope Data Release webinar! 🔭🧠 Attendees will learn about the experimental designs of the 2024 projects including studies related to psychedelics and visual perception. 🔗 alleninstitute.org/events/2025-op… #OpenScience
Tomorrow, we release a ton of data from last year OpenScope projects. Come to the webinar to learn about these projects and how to access the data.
TOMORROW - Join us for our 2025 OpenScope Data Release webinar! 🔭🧠 Attendees will learn about the experimental designs of the 2024 projects including studies related to psychedelics and visual perception. 🔗 alleninstitute.org/events/2025-op… #OpenScience
I am thrilled to share my postdoc work from the Soohyun Lee Lab, nature.com/articles/s4158…. Huge thanks to the awesome PI Soohyun Lee and collaborators Yuan Zhao, Ka Chun Lam, @fpereira, and Charles R Gerfen.
Happy to see this work led by Irene Onorato finally out in @CellReports showing "Distinct roles of PV and Sst interneurons in visually induced gamma oscillations" sciencedirect.com/science/articl…
New paper led by the great @OnoratoIrene! We show how the activity of distinct inhibitory interneurons is precisely coordinated in time with network activity "Distinct roles of PV and Sst interneurons in visually-induced gamma oscillations" biorxiv.org/content/10.110… 🧵1/n
How is V1 activity read-out to determine the presence of a visual stimulus? Our study using targeted 2-photon optogenetic stimulation in a detection task found that mice use a simple unweighted read-out strategy (1/6) biorxiv.org/content/10.110…
I'm happy to share the latest manuscript from my lab, where we reveal how behavioral context transforms the somatotopic map in sensory cortex into a value-based map in the midbrain SC that encodes stimulus priority. 1/n biorxiv.org/content/10.110…