Sam Connell
@samuelconnell
@samuelconnell.bsky.social Scientist and Global Sales Director @3i_Inc, foodie, family-man. Tai Chi and meditation matter. Compassion Heals. Microscopes Rock.
See our recent @NatureBiotech study SCP-Nano in flow! Mapping LNPs, AAVs, and DNA nanostructures to track targeting & unseen toxicity before clinical trials 🤩. Already >190K access, the most in recent years! 👇🏼 nature.com/articles/s4158…
Thrilled to share that our SCP-Nano currently ranks 3rd out of 192,338 tracked articles of a similar age across all journals and 1st out of 59 tracked articles of a similar age in @NatureBiotech. We hope SCP-Nano becomes a valuable imaging tool for drug discovery researchers.
See our recent @NatureBiotech study SCP-Nano in flow! Mapping LNPs, AAVs, and DNA nanostructures to track targeting & unseen toxicity before clinical trials 🤩. Already >190K access, the most in recent years! 👇🏼 nature.com/articles/s4158…
In this episode, I interviewed Dr. Sheila Teves (@sheilateves) and Dr. Lawrence David with a fellow graduate student at Duke, Enya (@DewarsEnya)! Words cannot explain how fun it was chatting with other Filipino scientists 😊🇵🇭 #representationmatters
I’ll say it since @Daniel_Stabley is so modest: his NeuroImaging Lab didn’t just ride the wave, they built it. While most were still squinting at the manual, Daniel’s crew had the entire Developmental Neurobiology Department MOSIACing like seasoned pros. Ain’t no edge but the…
Finally here! Our preprint on the MOSAIC, a multimodal adaptive optical microscope enabling non‑invasive in‑vivo imaging from molecules to organisms, is out. biorxiv.org/content/10.110… @Eric_Betzig @legant_lab
Finally here! Our preprint on the MOSAIC, a multimodal adaptive optical microscope enabling non‑invasive in‑vivo imaging from molecules to organisms, is out. biorxiv.org/content/10.110… @Eric_Betzig @legant_lab
While Gokul for all intents and purposes IS the ABC, I thought he deserves his own shout out, since none of this would have been possible without him: journals.biologists.com/jcs/article/13…
Finally here! Our preprint on the MOSAIC, a multimodal adaptive optical microscope enabling non‑invasive in‑vivo imaging from molecules to organisms, is out. biorxiv.org/content/10.110… @Eric_Betzig @legant_lab
Cell Division. Elongation. Differentiation. Capture the full spatiotemporal dynamics of root development with PlantScope automated montage-tracking! See 3i's @DvonWangenheim present at #ICAR2025 Friday June 19 at 9AM 🔬: @TNPlantBio @xiao_hui_li 🌍: intelligent-imaging.com/plantscope
Happy #microscopyMonday from @edwardlachica3 at #TCW2025 @HarvardMed MicRon "Day 1’s 3-channel embryo captured with our #lightsheet #microscope🧪🔬" 🧪micron.hms.harvard.edu/tissue-clearin… 🔬 intelligent-imaging.com/AxL #aslm #lightsheet #microscopy
Oh, just playing around with the #AllenBrainAtlas in #SlideBook for #FluorescenceFriday... 🔬 intelligent-imaging.com/AxL 🧠 brain-map.org 🖥️ intelligent-imaging.com/SlideBook
Great work from the @aliceyting lab (and collaborators) with their Marianas SDC and SlideBook! 🔬intelligent-imaging.com/marianas 🖥️ intelligent-imaging.com/slidebo
Tetanus on demand! (not for bioweapons, but for neuroscience research) Tetanus toxin induces paralysis by using a protease to cleave VAMP2, a protein required for synaptic vesicle fusion and neurotransmitter release. To harness this toxicity and use it as a beneficial tool for…
I couldn't be prouder of my co-authors and this piece for @ImmunityCP I Kudos to @im_mel_nology and @danielacerezo who did the heavy lifting of writing and figure design. I hope y'all enjoy it and learn as much as we did during the writing process 🔥 #Neutrophils #cancer
Grateful for the opportunity to work together with Daniela, @AndrsHidalgo16 @lai9uan to bring you our review on adaptations of neutrophils in cancer! We are really excited about the concepts we brought out in this review and hope you have as much fun discussing it as we did!
Congratulations to the @erturklab for another big paper on nanoparticles, with some nice manual ground-truth segmentation created in @syGlassVR. Some pretty nice movies in supplemental materials, too!
Excited to share our new technique for visualizing nanoparticles or viruses at single-cell resolution across the entire mouse body! This approach uses deep learning for precise quantification, and we’ve made the code available-give it a try with your dataset! @erturklab
LNP/mRNA therapeutics and AAV-based approaches require cell-level precision to achieve success without significant toxicity to other cells. To enable this, we now introduce SCP-Nano🤗 in @NatureBiotech: an AI-based technology for precision nanotechnology. nature.com/articles/s4158…
Our SCP-Nano paper is online now @NatureBiotech 🎉👏 Kudos to all the authors, collaborators and reviewers for bringing this important piece of work!
LNP/mRNA therapeutics and AAV-based approaches require cell-level precision to achieve success without significant toxicity to other cells. To enable this, we now introduce SCP-Nano🤗 in @NatureBiotech: an AI-based technology for precision nanotechnology. nature.com/articles/s4158…
Congrats to the whole community in the @erturklab including first author starting his new Lab this year at @LifeAtPurdue @jieluo692! Nice work y'all! Amazing contribution to this growing body of work.
LNP/mRNA therapeutics and AAV-based approaches require cell-level precision to achieve success without significant toxicity to other cells. To enable this, we now introduce SCP-Nano🤗 in @NatureBiotech: an AI-based technology for precision nanotechnology. nature.com/articles/s4158…
So hard to witness all this damage & suffering-not just walls are lost but the memories they held. Yet everyone is showing incredible resilience & stand together-thanks for your support. Our home is still standing, while so many are reduced to ashes. Hope the worst is behind us!
WATCH LIVE: CA officials give update on Eaton Fire near Pasadena. x.com/i/broadcasts/1…
Caltech has set up a disaster relief fund for Caltech and Jet Propulsion Lab community members affected by the fires. Many lived in Altadena, which has been very heavily damaged in the Eaton fire. Please consider giving. giving.caltech.edu/areas-to-suppo…
PAGER plasmids are now available on Addgene: addgene.org/browse/article…
How are cells in living tissues different from those in a dish? This question has puzzled scientists for decades. In our new preprint, we studied C. elegans roundworms to uncover how cells maintain unique internal environments. The results surprised us. biorxiv.org/content/10.110…
Check out our new Staygold-PX fusion, targeting PI(4,5)P2 I imaged in neurons! 🌊 Lipids create these mesmerizing waves at 300 ms exposures, revealing stunning dynamics in the plasma membrane. #Neuroscience #LipidBiology #LiveImaging #CellularArtistry #sciart #scicomm #bioart…