Jesper Sjöström @pjsjostrom.bsky.social
@pj_sjostrom
Associate Professor, McGill University | Director, Centre for Research in Neuroscience | Leader, BRaIN Program at the RI-MUHC | He/Him.
We are looking for an outstanding postdoc! We study cortical circuits, plasticity, and NMDARs with 2-photon excitation and quad-patch. We are in vibrant, multicultural Montreal—a city with exceptional quality of life. See ad for details. linkedin.com/jobs/view/4215…
In our most recent paper, now out in Nature Protocols, we provide a detailed recipe for how to do microsurgery of axons, one at a time, using a 2-photon Ti:Sa laser! Hope you find this approach inspiring for your research!
Our latest paper (@alanna_j_watt & @pj_sjostrom) is out in @NatureProtocols! (rdcu.be/d9f3v) When a chat goes wrong, do we always blame the listener? But then when a brain connection goes wrong, doesn't it seem unfair to always blame the "listener" neuron? (1/3)
Our most recent preprint: Presynaptically located NMDA receptors that signal non-ionotropically via JNK2 contribute to Spike-Timing-Dependent Plasticity, STDP. This explains the lack of frequency dependence in timing-dependent Long-Term Depression, tLTD.
Neocortical Layer-5 tLTD Relies on Non-Ionotropic Presynaptic NMDA Receptor Signaling biorxiv.org/content/10.110… #biorxiv_neursci
I wanted to post a thread here about our new paper in The Innovation called “Principles of visual cortex excitatory microcircuit organization” but now it appears that science twitter has moved to another site. So maybe I’ll see you there instead?
Just wanted to point out that science is really picking up on some of the other social-media platforms.
Saturday PM at #sfn2024 , check out poster B37 “The involvement of neocortical astrocytes in timing-dependent long-term depression” by my talented PhD student Airi Watanabe!
Going to #sfn2024 ? Check out nano38 “mRNA regulation and translation in plasticity” on Tuesday chaired by my talented postdoc @Hovy_Wong !
Getting ready (rushing) for #SfN24?Us too!😃 Excited about Neuron, Glia, RNA, Plasticity, FXS or Local Translation?Us too!😃 Come join us Tues 8th, with 14 great (&short!) talks on emerging roles of axonal, dendritic, glial proteostasis in health & disease pls spread the word!
What?? Oryx and Crake? This is just weird.
Wow, I'm the most dangerous little old lady of 84 you've ever heard of! Was it the blue XXXs? Too hot to read? Adult entertainment only? I wonder which satirists of ancient Rome would be banned there? And I'm banned from Russia, too! Oh alas, whatever will I do? Hit Utah with my…
Exciting times for voltage imaging! In a new study published today, our collaborators @attila_losonczy and @a_negrean find that behavior regulates electrical signals in neuronal dendrites in a structured but dynamic way. nature.com/articles/s4146…
Delighted to share our new Nature paper: rdcu.be/dNlMQ This works shows a surprising off-target effect of glutamate on another cell death channel, acid sensing ion channels (ASICs). It turns out that glutamate directly binds to ASICs as a positive allosteric modulator
New Nature Communications paper from @alanna_j_watt's lab: Cerebellar cortex axons to the cerebellar nuclei are spatially structured so that some cerebellar nuclei neurons receive input from multiple zones, suggesting that they integrate across modalities! nature.com/articles/s4146…
I am very proud to share our recent study published today showing structured connectivity between Purkinje cells and cells in the cerebellar nuclei, work done by the talented Kim Gruver (@ScienceJW ) and others. (1/5) nature.com/articles/s4146…
The Research Topic "Insights in synaptic neuroscience 2022" is finally finalized! With Karri Lamsa and Alfredo Kirkwood. Thanks to all who contributed! @FrontNeurosci frontiersin.org/articles/10.33…