Olivier Belli
@olivier_belli
@olivier-belli.bsky.social PhD in Molecular Biology 🎓 Interested in gene editing and functional genomics.
🚨 Very happy to announce the publication of my PhD work @NatureBiotech where we combined base and prime editing screens to investigate the impact of genetic variants in cancer. 🧵⬇️ nature.com/articles/s4158…
Combining base and prime editing to decipher which gene variants lead to cancer #NBTintheNews via @GENbio genengnews.com/topics/cancer/…
Thrilled to see our work out in @naturemethods today! We applied prime editing to multiplexed dropout screens and benchmarked the tool’s ability to induce phenotypes when installing premature stop codons in essential genes.
From @bsadamson and colleagues, a prime editing platform for high-throughput functional interrogation of up to tens of thousands of small genetic variants. nature.com/articles/s4159…
And read the News & Views from @fjsanchezrivera highlighting this work, along with related work published in @NatureBiotech from @randall_platt and colleagues, (nature.com/articles/s4158…), here: nature.com/articles/s4159…
Using CRISPR to decipher whether gene variants lead to cancer #NBTintheNews via @ETH_en ethz.ch/en/news-and-ev…
Researchers at ETH Zurich have combined two #GeneEditing methods. This enables them to quickly investigate the significance of many #GeneticMutations involved in the development and treatment of #Cancer. brnw.ch/21wOzs3
One of the major challenges in human genomics is the functional assessment of variants. Base and prime #CRISPR genome editing is making a big difference for meeting that challenge, as exemplified in this new report @NatureBiotech nature.com/articles/s4158… @randall_platt…