Nandan Gokhale
@nandangokhale
Assistant Prof. at CCHMC Immunobiology. RNA regulation in infection/immunity.
Our work on cellular RNA interactions with MAVS that promote antiviral signaling is finally live. So grateful to our indispensable collaborators as well as reviewers who helped to strengthen our work. #RNA #innateimmunity #virology @RamLabUW science.org/doi/10.1126/sc…
m7GpppNm - VERY EXCITED to share my postdoctoral work in with @RamlabUW, now out @bioRxiv. We found that cellular RNA interacts with MAVS, the adaptor protein of the RIG-I-like receptor pathway, to promote antiviral signaling. "🧵": buff.ly/45bzXui
Spread the word! Great opportunity for cancer immunology/immunology focused postsocs @CancerResearch
With @NIH cuts making research funding harder to secure, CRI is stepping up! We’re committing $2.5M to support 10 additional postdocs so that promising #CancerResearch doesn’t get left behind. Learn more: bit.ly/4iEQNsJ
We are very proud of our new preprint revealing #alphaviruses induces cellular #RNA #degradation via XRN1 and the decapping complex to feed viral #replication with nucleotides. Thanks to the whole team and collaborators for the fantastic work. biorxiv.org/content/10.110…
Absolutely delighted to announce I’ll be opening my lab next month @VersitiResearch in Milwaukee! Grateful for an outstanding home for the group and for great new colleagues at Versiti, @MedicalCollege, and @childrenswi who have been so welcoming! We’ll be hiring soon
Hello RNA World! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @CellReports, @FKHM and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit! tinyurl.com/ydn6e3ac
Delighted to share our manuscript @ImmunityCP ! Thanks to the editorial team and reviewers for an outstanding process, to all the coauthors, and to Steve @Jamequistlab, who is an incredible mentor! Glad to take questions Quick thread 1/5 free access link authors.elsevier.com/c/1khA83qNrU-h…
We are hiring a #postdoc and a research technician at @WeillCornell Medicine - Cornell University in New York City! We study the impact of diet and gut microbiota on inflammation, immunity, metabolism, and cancer. Join us if you are interested in #immunology and the #microbiota.
Really cool work from @TheHornerLab and colleagues highlighting a role for the UFMylation post-translational modification system in flavivirus viral particle production!
UFMylation promotes orthoflavivirus infectious particle production biorxiv.org/cgi/content/sh… #biorxiv_micrbio
So excited to join the Division of Immunobiology at Cincinnati Children's Hospital MC in March 2025. My lab will study how RNA biology regulates and is regulated by infection and immunity. We'll be hiring at all levels in 2025 - stay tuned! gokhalelab.com
Intriguing study in Science from @nandangokhale and colleagues @UW re how cellular RNAs regulate an antiviral immune signaling complex dubbed MAVS. Excited that Dr. Gokhale will be joining the faculty @CincyChildrens in March. @ThePasareLab #immunology science.org/doi/10.1126/sc…
This Perspective by Sonja Best and Adam Hage puts tuning the MAVS signalosome by cellular mRNAs into context. buff.ly/4fxVMcx #Immunology @ScienceMagazine
#Immunology out now @ScienceMagazine An unstructured region within MAVS interacts with cellular, rather than viral, RNA. This alters how MAVS interacts with other proteins and influences antiviral responses. buff.ly/4grnf18 By @nandangokhale, Ram Savan et al.
The Cliffe lab is hiring! Specifically, a research specialist to work closely with a Postdoc on a project investigating the impact of HSV infection on neurons and contribution of infection to neurodegenerative disease. This is part of a multi-team NIH funded project. Link 👇.
Check out this job in our lab. We are expanding our AML disparity research to include iPSC. Research Assistant II/III - Immunobiology - Grimes Lab jobs.cincinnatichildrens.org/s0NNNSq
Attention prospective postdocs: Are you interested in studying RNA modifications and using cutting edge technologies to uncover the role of m6A in physiology and disease? Come join our team! We are hiring! themeyerlab.com
It is wrong to even be able to see mangoes in the middle of November in the Midwest. The only consolation is knowing that these aren't really mangoes.
Thrilled to see this out and super excited to use this fantastic method!
Beyond thrilled to present our O-MAP—now *published* @naturemethods (!!!) O-MAP is a powerful new method for biochemically "dissecting" the subcellular microenvironment around an RNA of interest, using off-the-shelf parts and standard manipulations. 🧵 nature.com/articles/s4159…
My first postdoc paper is live! 🥳 Multiple CRISPR systems can interact for type VI-A spacer acquisition, check it out here:
Crosstalk between three CRISPR-Cas types enables primed type VI-A adaptation in Listeria seeligeri biorxiv.org/cgi/content/sh… #biorxiv_micrbio
I am very excited to share the first preprint from my postdoc with @UCSDCooperLab ! Read along to learn about tails and vertebral proportion 🧵 biorxiv.org/content/10.110…
The life of each one of us began when a sperm and an egg came together. But what actually happens at a molecular level? Our latest work @PauliGroup @CellPress reveals a conserved fertilization complex that bridges sperm and egg in vertebrates! (1/8) cell.com/cell/fulltext/…